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Safety risk management for low molecular weight process-related impurities in monoclonal antibody therapeutics: Categori
Design and control of integrated chromatography column sequences.
Optimization of integrated chromatography sequences for purification of biopharmaceuticals.
Rational design of peptide affinity ligands for the purification of therapeutic enzymes.
Identification of upstream culture conditions and harvest time parameters that affect host cell protein clearance.
Development of an activated carbon filtration step and high throughput screening method to remove host cell proteins fro
Leveraging single-pass tangential flow filtration to enable decoupling of upstream and downstream monoclonal antibody pr
Application of inline variable pathlength technology for rapid determination of dynamic binding capacity in downstream p
Transfer of continuous manufacturing process principles for mAb production in a GMP environment: A step in the transitio
Assessment of membrane-based downstream purification processes as a replacement to traditional resin bead for monoclonal
Host cell proteins in monoclonal antibody processing: Control, detection, and removal.
A modular and multi-functional purification strategy that enables a common framework for manufacturing scale integrated
A size-exclusion chromatography fingerprinting workflow for the development of flow-through polishing operations for mAb
Continuous capture of recombinant antibodies by ZnCl 2 precipitation without polyethylene glycol.
Pool-less processing to streamline downstream purification of monoclonal antibodies.
Purification of a peptide tagged protein via an affinity chromatographic process with underivatized silica.
Continuous Chromatography Purification of Virus-Based Biopharmaceuticals: A Shortcut Design Method.
Scale-Up of Protein Purification: Downstream Processing Issues.
Scale-Up of Protein Purification: Downstream Processing Issues.
Purification of Recombinant Glycoproteins from Pichia pastoris Culture Supernatants.
Progress of ligand-modified agarose microspheres for protein isolation and purification.
Large-scale crystallization as an intermediate processing step in insulin downstream process: explored advantages and id
Chromatographic purification of recombinant human erythropoietin.
Improved HCP Reduction Using a New, All-Synthetic Depth Filtration Media Within an Antibody Purification Process.
Quantitative definition and monitoring of the host cell protein proteome using iTRAQ - a study of an industrial mAb prod
Crystal Contact Engineering Enables Efficient Capture and Purification of an Oxidoreductase by Technical Crystallization
Magnetic Separation on a New Level: Characterization and Performance Prediction of a cGMP Compliant "Rotor-Stator&q
A Direct Approach for Process Development Using Single Column Experiments Results in Predictable Streamlined Multi-Colum
CRDSAT Generated by pCARGHO: A New Efficient Lectin-Based Affinity Tag Method for Safe, Simple, and Low-Cost Protein Pur
Magnetic Precipitation: A New Platform for Protein Purification.
The future of protein scaffolds as affinity reagents for purification.
A combined screening and in silico strategy for the rapid design of integrated downstream processes for process and prod
Flow management strategies for a connected purification process.
An impurity characterization based approach for the rapid development of integrated downstream purification processes.
Using artificial neural networks to accelerate flowsheet optimization for downstream process development.
Current technologies to endotoxin detection and removal for biopharmaceutical purification.
Dual-Stage Cross-Flow Filtration: Integrated Capture and Purification of Virus-Like Particles.
A fluidized-bed-riser adsorption system for continuous bioproduct recovery from crude feedstock.
Tailoring polishing steps for effective removal of polysorbate-degrading host cell proteins in antibody purification.
Continuous multi-column capture of monoclonal antibodies with convective diffusive membrane adsorbers.
Downstream Process Intensification for AAV Purification by Affinity Chromatography Using Single Pass Tangential Flow Fil
Experimental characterization and prediction of Escherichia coli host cell proteome retention during preparative chromat
Optimization of biopharmaceutical downstream processes supported by mechanistic models and artificial neural networks.
Implementation of an experimental and computational tool set to study protein-mAb interactions.
Emerging biomaterials for downstream manufacturing of therapeutic proteins.
Glycan profile of CHO derived IgM purified by highly efficient single step affinity chromatography.
Renaissance of protein crystallization and precipitation in biopharmaceuticals purification.
Green bioprocessing of protein from Chlorella vulgaris microalgae towards circular bioeconomy.
Efficient removal of antibody aggregates using TOYOPEARL MX-Trp-650M mixed-mode resin under salt or pH gradient elution.
Identification and tracking of problematic host cell proteins removed by a synthetic, highly functionalized nonwoven med
Non-protein A purification platform for continuous processing of monoclonal antibody therapeutics.
Definition and dynamic control of a continuous chromatography process independent of cell culture titer and impurities.
Optimization study on periodic counter-current chromatography integrated in a monoclonal antibody downstream process.
Rational design of affinity ligands for bioseparation.
Design of an integrated continuous downstream process for acid-sensitive monoclonal antibodies based on a calcium-depend
Comparative evaluation of integrated purification pathways for bacterial modular polyomavirus major capsid protein VP1 t
An automated buffer management system for small-scale continuous downstream bioprocessing.
Microfluidic platform for rapid screening of bacterial cell lysis.
The impact of endotoxin masking on the removal of endotoxin during manufacturing of a biopharmaceutical drug product.
Structural study of a light chain mispaired bispecific predicts mechanism of downstream separation.
Autonomous operation and quality monitoring of a continuous antibody downstream process.
Development of continuous processing platform utilizing aqueous two-phase extraction for purification of monoclonal anti
Integration of QSAR models with high throughput screening to accelerate the development of polishing chromatography unit
Improving the sustainability of biopharmaceutical downstream processing through buffer recycling.
Ionic liquids for biomacromolecule purification: from molecular interactions to practical applications.
Aqueous biphasic systems based on deep eutectic solvents for extraction of biopharmaceuticals in downstream processing.
Improved clearance of host cell protein impurities at the polishing purification step using multimodal chromatography.
Implementation of multimodal anion exchange chromatography to address product quality challenges and downstream platform
Solubilization of proteins in aqueous two-phase extraction through combinations of phase-formers and displacement agents
DOE-based process optimization for development of efficient methods for purification of recombinant hepatitis B surface
Protein partition coefficients can be estimated efficiently by hybrid shortcut calculations.
Integration of a complete downstream process for the automated lab-scale production of a recombinant protein.
Comparison of Tobacco Host Cell Protein Removal Methods by Blanching Intact Plants or by Heat Treatment of Extracts.
Advantages of MabSelect VH3, a novel VH3-specific Protein A resin, over its two conventional counterparts in purifying a
Feasibility of using continuous chromatography in downstream processing: Comparison of costs and product quality for a h
Automated optimization of resin selection, wash parameters, and elution parameters for protein A-based purifications.
A novel application of ion exchange chromatography in recombinant hepatitis B vaccine downstream processing: Improving r
One-step integrated clarification and purification of a monoclonal antibody using Protein A Mag Sepharose beads and a cG
Evaluating the efficacy of immobilized metal affinity chromatography (IMAC) for host cell protein (HCP) removal from ant
Effective strategies for host cell protein clearance in downstream processing of monoclonal antibodies and Fc-fusion pro
Downstream processing of a plant-derived malaria transmission-blocking vaccine candidate.
Purification of cell culture-derived influenza A virus via continuous anion exchange chromatography on monoliths.
Purification and functional characterization of gag-spike virus-like particles: Process optimization for efficient vacci
Host Cell Protein Profiling by Targeted and Untargeted Analysis of Data Independent Acquisition Mass Spectrometry Data w
Label-Free Potentiometric Ion Flux Immunosensor for Determination of Recombinant Human Myelin Basic Protein: Application
Magnetic One-Step Purification of His-Tagged Protein by Bare Iron Oxide Nanoparticles.
Downstream processing of lactoperoxidase from milk whey by involving liquid emulsion membrane.
Polyethylene glycol precipitation: fundamentals and recent advances.
Current trends and challenges in the downstream purification of bispecific antibodies.
Cationic polymer precipitation for enhanced impurity removal in downstream processing.
High-performance countercurrent membrane purification for host cell protein removal from monoclonal antibody products.
Accounting for host cell protein behavior in anion-exchange chromatography.
In silico mediated workflow for rapid development of downstream processing: Orthogonal product-related impurity removal
Peptide binding to metal oxide nanoparticles.
[Optimization and application of caprylic acid precipitation in the purification of monoclonal antibody].
Novel method for production and purification of untagged pneumococcal surface protein A from clade 1.
Foam fractionation Tags (F-Tags) enabling surfactant-free, activity-preserving recovery of enzymes.
Streamlined purification of ADDomer nanoparticles for scalable biomanufacturing.
Cost-effective downstream processing of recombinantly produced pexiganan peptide and its antimicrobial activity.
A Generic Procedure for the Isolation of pH- and Magnesium-Responsive Chicken scFvs for Downstream Purification of Human
Integrated Clarification and Purification of Monoclonal Antibodies by Membrane Based Separation of Aqueous Two-Phase Sys
In-Line Monitoring of Downstream Purification Processes for VSV Based SARS-CoV-2 Vaccine Using a Novel Technique.
Scalable, Robust and Highly Productive Novel Convecdiff Membrane Platform for mAb Capture.
Evaluation of the Robustness Verification of Downstream Production Process for Inactivated SARS-CoV-2 Vaccine and Differ
Satisfying QTPP of Erythropoietin Biosimilar by QbD through DoE-Derived Downstream Process Engineering.
Toward microfluidic continuous-flow and intelligent downstream processing of biopharmaceuticals.
The lyophilized chloroplasts store synthetic DARPin G3 as bioactive encapsulated organelles.
Protein purification strategies must consider downstream applications and individual biological characteristics.
jslee@bcm.edu
Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain-based vaccine candidate, RBD219-
anna.antecka@p.lodz.pl
Comparison of downstream processing methods in purification of highly active laccase.
ram.shankar@plasmidfactory.com
Recombinant expression of Barnase in Escherichia coli and its application in plasmid purification.
f.saadat@ut.ac.ir
Economic purification of recombinant uricase by artificial oil bodies.
juergen.hubbuch@kit.edu
Integrated Process for Capture and Purification of Virus-Like Particles: Enhancing Process Performance by Cross-Flow Fil
awchung@unimelb.edu.au
Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcγ Receptors: Impli
johannes.buyel@ime.fraunhofer.de
Optimized Blanching Reduces the Host Cell Protein Content and Substantially Enhances the Recovery and Stability of Two P
spventura@ua.pt
Extraction and purification of phycobiliproteins from algae and their applications.
maragfreire@ua.pt
Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation.
eleonora.lalli2@unibo.it
Affinity Membranes and Monoliths for Protein Purification.
min.du@thermofisher.com
Applying UHPLC-HRAM MS/MS Method to Assess Host Cell Protein Clearance during the Purification Process Development of Th
alexander.tappe@sartorius.com
Optimization of Tangential Flow Filtration for High-Yield, Scalable Downstream Processing of Adeno-Associated Virus.
angela.valentic@kit.edu
Absolute Quantification of Hepatitis B Core Antigen (HBcAg) Virus-like Particles and Bound Nucleic Acids.
gaokai@asymchem.com.cn
Removal of Aggregates During Bispecific Antibody Purification Using Hydrophobic Interaction Chromatography.
mikhail.polzikov@gmail.com
Purification Process of a Recombinant Human Follicle Stimulating Hormone Biosimilar (Primapur®) to Yield a Pharmaceutica
amine.kamen@mcgill.ca
Membrane Chromatography-Based Downstream Processing for Cell-Culture Produced Influenza Vaccines.
sojha@atb-potsdam.de
Exploitation of Ultrasound Technique for Enhancement of Microbial Metabolites Production.
d_doroud@pasteur.ac.ir
Determining buffer conditions for downstream processing of VLP-based recombinant hepatitis B surface antigen using multi