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Mixed Substrate Co Feeding Sorbitol Glycerol Metha

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<2016

Response surface methodology based optimization of β-glucosidase production from Pichia pastoris.

2014 Applied biochemistry and biotechnology

Batra, Jyoti; Beri, Dhananjay; Mishra, Saroj

DOI

Enhancement of cell viability and alkaline polygalacturonate lyase production by sorbitol co-feeding with methanol in Pi

2010 Bioresource technology

Wang, Zhihao; Wang, Yun; Zhang, Dongxu et al.

DOI

Dynamic flux balance analysis for pharmaceutical protein production by Pichia pastoris: human growth hormone.

2011 Enzyme and microbial technology

Calık, Pınar; Sahin, Merve; Taşpınar, Hatice et al.

DOI

Optimization of the heterologous production of a Rhizopus oryzae lipase in Pichia pastoris system using mixed substrates

2010 Enzyme and microbial technology

Arnau, Carolina; Ramon, Ramon; Casas, Carles et al.

DOI

Combinatorial strategy of sorbitol feeding and low-temperature induction leads to high-level production of alkaline β-ma

2011 Enzyme and microbial technology

Zhu, Taicheng; You, Lijin; Gong, Fuyu et al.

DOI

Sorbitol co-feeding reduces metabolic burden caused by the overexpression of a Rhizopus oryzae lipase in Pichia pastoris

2007 Journal of biotechnology

Ramón, Ramón; Ferrer, Pau; Valero, Francisco

DOI

Regulation of alcohol oxidase of a recombinant Pichia pastoris Mut+ strain in transient continuous cultures.

2007 Journal of biotechnology

Jungo, Carmen; Marison, Ian; von Stockar, Urs

DOI

A quantitative analysis of the benefits of mixed feeds of sorbitol and methanol for the production of recombinant avidin

2007 Journal of biotechnology

Jungo, Carmen; Schenk, Jonas; Pasquier, Muriel et al.

DOI

Mixed feeds of glycerol and methanol can improve the performance of Pichia pastoris cultures: A quantitative study based

2007 Journal of biotechnology

Jungo, Carmen; Marison, Ian; von Stockar, Urs

DOI

Enhanced porcine circovirus Cap protein production by Pichia pastoris with a fuzzy logic DO control based methanol/sorbi

2014 Journal of biotechnology

Ding, Jian; Zhang, Chunling; Gao, Minjie et al.

DOI

Expression and purification of ancrod, an anticoagulant drug, in Pichia pastoris.

2007 Protein expression and purification

Yu, Xueling; Li, Zhaofa; Xia, Xiaobing et al.

DOI

Cloning, expression and optimized production in a bioreactor of bovine chymosin B in Pichia (Komagataella) pastoris unde

2013 Protein expression and purification

Noseda, Diego Gabriel; Recúpero, Matías Nicolás; Blasco, Martín et al.

DOI

Metabolic flux analysis of recombinant Pichia pastoris growing on different glycerol/methanol mixtures by iterative fitt

2014 New biotechnology

Jordà, Joel; de Jesus, Sérgio S; Peltier, Solenne et al.

DOI

Optimization of the high-level production of Rhizopus oryzae lipase in Pichia pastoris.

2001 Journal of biotechnology

Minning, S; Serrano, A; Ferrer, P et al.

DOI

Angiostatin production in cultivation of recombinant Pichia pastoris fed with mixed carbon sources.

2003 Biotechnology letters

Xie, Jingli; Zhang, Li; Ye, Qin et al.

DOI

The influence of carbon sources on recombinant-human- growth-hormone production by Pichia pastoris is dependent on pheno

2009 Biotechnology and applied biochemistry

Orman, Mehmet Ali; Calik, Pinar; Ozdamar, Tunçer H

DOI

Metabolic flux profiling of Pichia pastoris grown on glycerol/methanol mixtures in chemostat cultures at low and high di

2007 Microbiology (Reading, England)

Solà, Aina; Jouhten, Paula; Maaheimo, Hannu et al.

DOI

Increasing secretion of a bivalent anti-T-cell immunotoxin by Pichia pastoris.

2004 Applied and environmental microbiology

Woo, Jung Hee; Liu, Yuan Yi; Stavrou, Scott et al.

DOI

Transcriptional response of P. pastoris in fed-batch cultivations to Rhizopus oryzae lipase production reveals UPR induc

2007 Microbial cell factories

Resina, David; Bollók, Mónika; Khatri, Narendar K et al.

DOI

Comprehensive clone screening and evaluation of fed-batch strategies in a microbioreactor and lab scale stirred tank bio

2014 Microbial cell factories

Hemmerich, Johannes; Adelantado, Núria; Barrigón, José Manuel et al.

DOI

A quantitative study of methanol/sorbitol co-feeding process of a Pichia pastoris Mut⁺/pAOX1-lacZ strain.

2013 Microbial cell factories

Niu, Hongxing; Jost, Laurent; Pirlot, Nathalie et al.

DOI

Change in product selectivity during the production of glyceric acid from glycerol by Gluconobacter strains in the prese

2013 AMB Express

Sato, Shun; Morita, Naoki; Kitamoto, Dai et al.

DOI

Process development in Hansenula polymorpha and Arxula adeninivorans, a re-assessment.

2009 Microbial cell factories

Stöckmann, Christoph; Scheidle, Marco; Dittrich, Barbara et al.

DOI

Application of simple fed-batch technique to high-level secretory production of insulin precursor using Pichia pastoris

2010 Microbial cell factories

Gurramkonda, Chandrasekhar; Polez, Sulena; Skoko, Natasa et al.

DOI

Stepwise engineering of a Pichia pastoris D-amino acid oxidase whole cell catalyst.

2010 Microbial cell factories

Abad, Sandra; Nahalka, Jozef; Bergler, Gabriele et al.

DOI

Functional recombinant protein is present in the pre-induction phases of Pichia pastoris cultures when grown in bioreact

2014 Microbial cell factories

Bawa, Zharain; Routledge, Sarah J; Jamshad, Mohammed et al.

DOI

Systems-level organization of yeast methylotrophic lifestyle.

2015 BMC biology

Rußmayer, Hannes; Buchetics, Markus; Gruber, Clemens et al.

DOI

Genome-scale metabolic reconstructions of Pichia stipitis and Pichia pastoris and in silico evaluation of their potentia

2012 BMC systems biology

Caspeta, Luis; Shoaie, Saeed; Agren, Rasmus et al.

DOI

Development of a mixed feed strategy for a recombinant Pichia pastoris strain producing with a de-repression promoter.

2015 Microbial cell factories

Capone, Simona; Horvat, Jernej; Herwig, Christoph et al.

DOI

Pichia pastoris regulates its gene-specific response to different carbon sources at the transcriptional, rather than the

2015 BMC genomics

Prielhofer, Roland; Cartwright, Stephanie P; Graf, Alexandra B et al.

DOI

Validation of an FBA model for Pichia pastoris in chemostat cultures.

2014 BMC systems biology

Morales, Yeimy; Tortajada, Marta; Picó, Jesús et al.

DOI

An artificial neural network for membrane-bound catechol-O-methyltransferase biosynthesis with Pichia pastoris methanol-

2015 Microbial cell factories

Pedro, Augusto Q; Martins, Luís M; Dias, João M L et al.

DOI

Independent exponential feeding of glycerol and methanol for fed-batch culture of recombinant Hansenula polymorpha DL-1.

2003 Applied biochemistry and biotechnology

Moon, H; Kim, S W; Lee, J et al.

DOI

Oxygen vectors used for S-adenosylmethionine production in recombinant Pichia pastoris with sorbitol as supplemental car

2008 Journal of bioscience and bioengineering

Zhang, Jian-Guo; Wang, Xue-Dong; Zhang, Ji-Ning et al.

DOI

Production of recombinant human antithrombin by Pichia pastoris.

2005 Journal of bioscience and bioengineering

Kuwae, Shinobu; Ohyama, Masao; Ohya, Tomoshi et al.

DOI

Non-repressing carbon sources for alcohol oxidase (AOX1) promoter of Pichia pastoris.

2001 Journal of bioscience and bioengineering

Inan, M; Meagher, M M

DOI

Potential of Ophiostoma piceae sterol esterase for biotechnologically relevant hydrolysis reactions.

2013 Bioengineered

Barba Cedillo, Víctor; Prieto, Alicia; Martínez, María Jesús

DOI

Upscale of recombinant α-L-rhamnosidase production by Pichia pastoris Mut(S) strain.

2015 Frontiers in microbiology

Markošová, Kristína; Weignerová, Lenka; Rosenberg, Michal et al.

DOI

Analysis of single-chain antibody production in Pichia pastoris using on-line methanol control in fed-batch and mixed-fe

2001 Biotechnology and bioengineering

Hellwig, S; Emde, F; Raven, N P et al.

[Effects of mixed carbon sources on glucose oxidase production by recombinant Pichia pastoris].

2013 Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Shen, Yina; Gu, Lei; Zhang, Juan et al.

[Effects of different methanol feeding strategy on hirudin production in high-density fermentation by recombinant Pichia

2002 Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Zhou, Xiang-Shan; Fan, Wei-Min; Zhang, Yuan-Xing

High-level secretory expression of human procarboxypeptidase B by Fed-Batch cultivation of Pichia pastoris and its parti

2008 Journal of microbiology and biotechnology

Kim, Mi-Jin; Kim, Sang-Hyuk; Lee, Jae Hyung et al.

[Feeding of mixed-carbon-resource during the expression phase in cultivation of recombinant Pichia pastoris expressing a

2003 Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Xie, Jing-Li; Zhou, Qing-Wei; Zhang, Li et al.

[High-level production of alkaline polygalacturonate lyase in recombinant Pichia pastoris].

2008 Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Wang, Yun; Hua, Zhaozhe; Liu, Liming et al.

Variations in protein glycosylation in Hansenula polymorpha depending on cell culture stage.

2007 Journal of microbiology and biotechnology

Kim, So-Young; Sohn, Jung-Hoon; Pyun, Yu-Ryang et al.

A rational approach to improving productivity in recombinant Pichia pastoris fermentation.

2001 Biotechnology and bioengineering

d'Anjou, M C; Daugulis, A J

DOI

Effect of methanol feeding strategies on production and yield of recombinant mouse endostatin from Pichia pastoris.

2003 Biotechnology and bioengineering

Trinh, L B; Phue, J N; Shiloach, Joseph

DOI

Metabolic flux analysis for recombinant protein production by Pichia pastoris using dual carbon sources: Effects of meth

2010 Biotechnology and bioengineering

Celik, Eda; Calik, Pinar; Oliver, Stephen G

DOI

A dynamic fed batch strategy for a Pichia pastoris mixed feed system to increase process understanding.

2012 Biotechnology progress

Zalai, Dénes; Dietzsch, Christian; Herwig, Christoph et al.

DOI

Production of a sterol esterase from Ophiostoma piceae in batch and fed-batch bioprocesses using different Pichia pastor

2014 Biotechnology progress

Cedillo, Víctor Barba; Martínez, María Jesús; Arnau, Carolina et al.

DOI

Effect of dilution rate and methanol-glycerol mixed feeding on heterologous Rhizopus oryzae lipase production with Pichi

2015 Biotechnology progress

Canales, Christian; Altamirano, Claudia; Berrios, Julio

DOI

Pathway analysis of Pichia pastoris to elucidate methanol metabolism and its regulation for production of recombinant pr

2014 Biotechnology progress

Unrean, Pornkamol

DOI

Fed-batch methanol feeding strategy for recombinant protein production by Pichia pastoris in the presence of co-substrat

2009 Yeast (Chichester, England)

Celik, Eda; Calik, Pinar; Oliver, Stephen G

DOI

Production of recombinant human bile salt-stimulated lipase in Pichia pastoris.

2001 Protein expression and purification

Murasugi, A; Asami, Y; Mera-Kikuchi, Y

DOI

Regulation of alcohol oxidase synthesis in Hansenula polymorpha: oversynthesis during growth on mixed substrates and ind

1980 Archives of microbiology

Eggeling, L; Sahm, H

DOI

Biosynthetic production of type II fish antifreeze protein: fermentation by Pichia pastoris.

1997 Applied microbiology and biotechnology

Loewen, M C; Liu, X; Davies, P L et al.

DOI

High-level expression of a truncated 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenes in Pichia pastoris by optimi

2008 Applied microbiology and biotechnology

Huang, Huoqing; Yang, Peilong; Luo, Huiying et al.

DOI

Improving intracellular production of recombinant protein in Pichia pastoris using an optimized preinduction glycerol-fe

2008 Applied microbiology and biotechnology

Wei, Chun; Zhou, Xiangshan; Zhang, Yuanxing

DOI

Codon optimization of xylA gene for recombinant glucose isomerase production in Pichia pastoris and fed-batch feeding st

2015 Bioprocess and biosystems engineering

Ata, Özge; Boy, Erdem; Güneş, Hande et al.

DOI

Methanol/sorbitol co-feeding induction enhanced porcine interferon-α production by P. pastoris associated with energy me

2012 Bioprocess and biosystems engineering

Gao, Min-Jie; Li, Zhen; Yu, Rui-Song et al.

DOI

Enhanced production of Thermomyces lanuginosus lipase in Pichia pastoris via genetic and fermentation strategies.

2014 Journal of industrial microbiology & biotechnology

Fang, Zhonggang; Xu, Li; Pan, Dujie et al.

DOI

Pichia pastoris fermentation with mixed-feeds of glycerol and methanol: growth kinetics and production improvement.

2003 Journal of industrial microbiology & biotechnology

Zhang, Wenhui; Hywood Potter, Karen J; Plantz, Bradley A et al.

DOI

Transcriptional investigation of the effect of mixed feeding to identify the main cellular stresses on recombinant Pichi

2013 Journal of industrial microbiology & biotechnology

Zhu, Taicheng; Hang, Haifeng; Chu, Ju et al.

DOI

Improving Performance and Operational Stability of Porcine Interferon-α Production by Pichia pastoris with Combinational

2015 Applied biochemistry and biotechnology

Gao, Min-Jie; Zhan, Xiao-Bei; Gao, Peng et al.

DOI

Evaluation of Mut(S) and Mut⁺ Pichia pastoris strains for membrane-bound catechol-O-methyltransferase biosynthesis.

2015 Applied biochemistry and biotechnology

Pedro, A Q; Oppolzer, D; Bonifácio, M J et al.

DOI

Characterization of catalase-negative mutants of methylotrophic yeast Hansenula polymorpha.

1991 Folia microbiologica

Aminova, L R; Kyslíková, E; Volfová, O et al.

DOI

[Effects of mixed carbon sources in cultivation of recombinant Pichia pastoris for polygalacturonate lyase production].

2009 Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Wang, Zhihao; Zhang, Dongxu; Li, Jianghua et al.

[Enhanced porcine interferon-alpha production by Pichia pastoris by methanol/sorbitol co-feeding and energy metabolism s

2012 Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Wang, Huihui; Jin, Hu; Gao, Minjie et al.

Metadata Only

31

Enhancing the expression of recombinant small laccase in Pichia pastoris by a double promoter system and application in

2021 Folia microbiologica DOI

Improvement of the recombinant phytase expression by intermittent feeding of glucose during the induction phase of methy

2024 Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] DOI

Sorbitol/methanol mixed induction reduces process impurities and improves centrifugal dewatering in Pichia pastoris cult

2019 Enzyme and microbial technology DOI

Fed-batch production and secretion of streptavidin by Hansenula polymorpha: Evaluation of genetic factors and bioprocess

2016 Journal of biotechnology DOI

Combining expression and process engineering for high-quality production of human sialyltransferase in Pichia pastoris.

2016 Journal of biotechnology DOI

Substitution of the 5&#x27;-untranslated region in the alcohol oxidase 1 promoter of Komagataella phaffii alleviated the

2025 Journal of biotechnology DOI

Co-feeding strategy alleviates hypoxic stress in large-scale bioreactor for optimal production of secretory recombinant

2023 Journal of biotechnology DOI

High-level expression of Humicola insolens cutinase in Pichia pastoris without carbon starvation and its use in cotton f

2019 Journal of biotechnology DOI

Engineering Komagataella phaffii to produce lycopene sustainably from glucose or methanol.

2025 Metabolic engineering DOI

Production in stirred-tank bioreactor of recombinant bovine chymosin B by a high-level expression transformant clone of

2016 Protein expression and purification DOI

The molecular modification, expression, and the antibacterial effects studies of human lysozyme.

2024 Bioscience, biotechnology, and biochemistry DOI

[High-level production of glucose oxidase by recombinant Pichia pastoris using a combined strategy].

2016 Sheng wu gong cheng xue bao = Chinese journal of biotechnology DOI

Purification and Characterization of β-Mannanase Derived from Rhizopus microsporus var. rhizopodiformis Expressed in Kom

2024 Foods (Basel, Switzerland) DOI

Efficient Heterologous Production of Rhizopus oryzae Lipase via Optimization of Multiple Expression-Related Helper Prote

2018 International journal of molecular sciences DOI

Bioprocess and downstream optimization of recombinant human growth hormone in Pichia pastoris.

2018 Research in pharmaceutical sciences DOI

Evaluation of Sorbitol-Methanol Co-Feeding Strategy on Production of Recombinant Human Growth Hormone in Pichia Pastoris

2017 Iranian journal of pharmaceutical research : IJPR

Secretion of Pseudomonas aeruginosa Lipoxygenase by Pichia pastoris upon Glycerol Feed.

2020 Biotechnology journal DOI

Biocalorimetric monitoring of glycoengineered P. pastoris cultivation for the production of recombinant huIFNα2b: A quan

2020 Biotechnology progress DOI

Downregulation by organic nitrogen of AOX1 promoter used for controlled expression of foreign genes in the yeast Pichia

2019 Yeast (Chichester, England) DOI

Kinetic Modeling of Pichia pastoris Bioreactor Systems Under Different Operating Conditions: Batch, Fed-Batch, and Chemo

2026 Methods in molecular biology (Clifton, N.J.) DOI

Transcriptomic insights into methanol utilization in Pichia pastoris lacking AOX genes under co-feeding conditions.

2025 Archives of microbiology DOI

Integrating metabolic modeling and population heterogeneity analysis into optimizing recombinant protein production by K

2018 Applied microbiology and biotechnology DOI

Impact of glycerol feeding profiles on STEAP1 biosynthesis by Komagataella pastoris using a methanol-inducible promoter.

2021 Applied microbiology and biotechnology DOI

The growth of Pichia pastoris Mut+ on methanol-glycerol mixtures fits to interactive dual-limited kinetics: model develo

2018 Bioprocess and biosystems engineering DOI

Enhancing xylanase expression of Komagataella phaffii induced by formate through Mit1 co-expression.

2022 Bioprocess and biosystems engineering DOI

Optimization of dilution rate and mixed carbon feed for continuous production of recombinant plant sucrose:sucrose 1-fru

2024 Bioprocess and biosystems engineering DOI

A comparative study of glycerol and sorbitol as co-substrates in methanol-induced cultures of Pichia pastoris: temperatu

2017 Journal of industrial microbiology & biotechnology DOI

Influence of methanol/sorbitol co-feeding rate on pAOX1 induction in a Pichia pastoris Mut+ strain in bioreactor with li

2016 Journal of industrial microbiology & biotechnology DOI

Medium optimization for enhanced production of recombinant lignin peroxidase in Pichia pastoris.

2023 Biotechnology letters DOI

Enhanced truncated-t-PA (CT-b) expression in high-cell-density fed-batch cultures of Pichia pastoris through optimizatio

2016 Bioprocess and biosystems engineering DOI

Developing a metabolic model-based fed-batch feeding strategy for Pichia pastoris fermentation through fine-tuning of th

2023 Microbial biotechnology DOI

Needs Review

5
No corresponding author in OpenAlex
2023 Scientific reports DOI
agris.pentjuss@gmail.com
No corresponding author in OpenAlex
2017 BMC biotechnology DOI
feedbiotech@yahoo.com
No corresponding author in OpenAlex
2018 Microbial cell factories DOI
No corresponding author in OpenAlex
2023 Frontiers in bioengineering and biotechnology DOI
anarang@dbeb.iitd.ac.in
No corresponding author in OpenAlex
2020 Frontiers in microbiology DOI
huangzunxi@163.com

Author Found

8
Yuanxing; Zhou, Xiangshan; Song

xszhou@ecust.edu.cn

2017 Scientific reports
DOI
2020 The Analyst
DOI
Oliver; Kopp, Julian

julian.kopp@tuwien.ac.at

2024 Microbial cell factories
DOI
Martina; Toivari, Mervi; Penttilä

mervi.toivari@vtt.fi

2019 Fungal biology and biotechnology
DOI
Andrius; Slibinskas, Rimantas

rimantas.slibinskas@bti.vu.lt

2025 Microbial cell factories
DOI
Adalberto Jr

pessoajr@usp.br

2019 Frontiers in bioengineering and biotechnology
DOI
Sato, Shun; Kitamoto

shun.satou@aist.go.jp

2017 Journal of oleo science
DOI
Ebbecke, Jan Peter; Schlauch

ebbecke@iftc.uni-hannover.de

2025 Applied microbiology and biotechnology
DOI