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Methylthioadenosine (MTA) boosts cell‐specific productivities of Chinese hamster ovary cultures: dosage effects on proli
The relationship of metabolic burden to productivity levels in CHO cell lines.
Real‐time monitoring of specific oxygen uptake rates of embryonic stem cells in a microfluidic cell culture device
Hyperosmotic stimulus study discloses benefits in ATP supply and reveals miRNA/mRNA targets to improve recombinant prote
Polysome profiling of mAb producing CHO cell lines links translational control of cell proliferation and recombinant mRN
Glycoengineering in CHO Cells: Advances in Systems Biology
On‐Line Control of Glucose Concentration in High‐Yielding Mammalian Cell Cultures Enabled Through Oxygen Transfer Rate M
Bioprocessing of Recombinant CHO-K1, CHO-DG44, and CHO-S: CHO Expression Hosts Favor Either mAb Production or Biomass Sy
High Cell Density Perfusion Culture has a Maintained Exoproteome and Metabolome
Transcriptome Analysis of CHO Cell Size Increase During a Fed-Batch Process
Combining Butyrated ManNAc with Glycoengineered CHO Cells Improves EPO Glycan Quality and Production.
Application of the Bradford Assay for Cell Lysis Quantification: Residual Protein Content in Cell Culture Supernatants
mRNA Transfection into CHO‐Cells Reveals Production Bottlenecks
Multi‐Omics Reveals Impact of Cysteine Feed Concentration and Resulting Redox Imbalance on Cellular Energy Metabolism an
Temperature Down‐Shift Modifies Expression of UPR‐/ERAD‐Related Genes and Enhances Production of a Chimeric Fusion Prote
Modeling the Effect of Amino Acids and Copper on Monoclonal Antibody Productivity and Glycosylation: A Modular Approach
Continuous optical in‐line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency w
Real‐time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture usi
Production of novel SARS‐CoV‐2 Spike truncations in Chinese hamster ovary cells leads to high expression and binding to
Hierarchical time‐series analysis of dynamic bioprocess systems
Comparison of mechanistic and hybrid modeling approaches for characterization of a CHO cultivation process: Requirements
Enhancing recombinant protein and viral vector production in mammalian cells by targeting the YTHDF readers of <i>N</i><
NAD<sup>+</sup> supplementation improves mAb productivity in CHO cells via a glucose metabolic shift
The impact of expression vector position on transgene transcription allows for rational expression vector design in a ta
Dissecting cell death pathways in fed‐batch bioreactors
Feasibility and performance of cross‐clone Raman calibration models in CHO cultivation
Rosmarinic acid enhances CHO cell productivity and proliferation through activation of the unfolded protein response and
Evaluation of NAD<sup>+</sup> precursors for improved metabolism and productivity of antibody‐producing CHO cell
Evaluation of “Difficult‐to‐Express” Monoclonal Antibodies in a CHO‐Based Hybrid Site‐Specific Integration System Under
Modulation of Antibody Glycosylation in Chinese Hamster Ovary Cells: Experimental and Computational Analyses Provide Mec
Glycoprofiling effects of media additives on IgG produced by CHO cells in fed‐batch bioreactors
Mannose metabolism in recombinant CHO cells and its effect on IgG glycosylation.
Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time
Segmented linear modeling of CHO fed‐batch culture and its application to large scale production
Model‐based investigation of intracellular processes determining antibody Fc‐glycosylation under mild hypothermia
Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to
Production and characterization of active recombinant human factor II with consistent sialylation.
Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody–peptide
Exploring cellular behavior under transient gene expression and its impact on mAb productivity and Fc‐glycosylation
Intracellular response to process optimization and impact on productivity and product aggregates for a high-titer CHO ce
cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV‐1 envelope glycoprotein vacci
Identification of process conditions influencing protein aggregation in Chinese hamster ovary cell culture.
Impact of cell culture media additives on IgG glycosylation produced in Chinese hamster ovary cells
Control of IgG glycosylation by in situ and real‐time estimation of specific growth rate of CHO cells cultured in biorea
Enhancing the functionality of a microscale bioreactor system as an industrial process development tool for mammalian pe
Model-based optimization of antibody galactosylation in CHO cell culture.
Characterization of intact glycopeptides reveals the impact of culture media on site‐specific glycosylation of EPO‐Fc fu
Reduction of IL-2 fragmentation during manufacturing of a novel immunocytokine by DoE process optimization.
Process‐induced cell cycle oscillations in CHO cultures: Online monitoring and model‐based investigation
Impacts of intentional mycoplasma contamination on CHO cell bioreactor cultures
Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells
Online control of cell culture redox potential prevents antibody interchain disulfide bond reduction.
<i>S</i>‐adenosylmethionine and methylthioadenosine boost cellular productivities of antibody forming Chinese hamster ov
Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis
Production of trimeric SARS‐CoV‐2 spike protein by CHO cells for serological COVID‐19 testing
Application of metabolic modeling for targeted optimization of high seeding density processes
Media on‐demand: Continuous reconstitution of a chemically defined media directly from solids
Hyperosmolality in CHO culture: Effects on cellular behavior and morphology
Process intensification to produce a difficult‐to‐express therapeutic enzyme by high cell density perfusion or enhanced
Unveiling the CHO surfaceome: Identification of cell surface proteins reveals cell aggregation‐relevant mechanisms
Multi‐omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer, and
A genome‐scale nutrient minimization forecast algorithm for controlling essential amino acid levels in CHO cell cultures
Soft‐sensors application for automated feeding control in high‐throughput mammalian cell cultures
Effects of pyruvate on primary metabolism and product quality for a high‐density perfusion process
Strategies to control therapeutic antibody glycosylation during bioprocessing: Synthesis and separation
Manipulation of mRNA translation elongation influences the fragmentation of a biotherapeutic Fc‐fusion protein produced
“Organized stress” for robust scale‐up of intensified production process with fed‐batch seed bioreactor
Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided
Addressing amino acid‐derived inhibitory metabolites and enhancing CHO cell culture performance through DOE‐guided media
Chemical inhibitors of hexokinase‐2 enzyme reduce lactate accumulation, alter glycosylation processing, and produce alte
Repressing expression of difficult‐to‐express recombinant proteins during the selection process increases productivity o
Sodium chloride impacts glycosylation and N‐ and O‐glycan site occupancy of an Fc‐fusion protein
Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation
Developing microRNAs as engineering tools to modulate monoclonal antibody galactosylation
Mimicking CHO large‐scale effects in the single multicompartment bioreactor: A new approach to access scale‐up behavior
Platform development for high‐throughput optimization of perfusion processes—Part II: Variation of perfusion rate strate
A Novel, Site‐Specific N‐Linked Glycosylation Model Provides Mechanistic Insights Into the Process‐Condition Dependent D
Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothe
Investigating the impact of synonymous gene recoding on a recombinantly expressed monoclonal antibody under different pr
Identifying a robust design space for glycosylation during monoclonal antibody production.
A comparison of orbitally‐shaken and stirred‐tank bioreactors: pH modulation and bioreactor type affect CHO cell growth
Exploring the linkage between cell culture process parameters and downstream processing utilizing a plackett-burman desi
Analysis of Tubespins as a suitable scale-down model of bioreactors for high cell density CHO cell culture.
Characterization of mammalian cell culture raw materials by combining spectroscopy and chemometrics
A practical approach in bioreactor scale-up and process transfer using a combination of constant P/V and vvm as the crit
A system identification approach for developing model predictive controllers of antibody quality attributes in cell cult
Impact of media and antifoam selection on monoclonal antibody production and quality using a high throughput micro‐biore
Fluctuations in dissolved oxygen concentration during a CHO cell culture process affects monoclonal antibody productivit
High‐throughput screening of antibody‐expressing CHO clones using an automated shaken deep‐well system
Process development for an inducible rituximab‐expressing Chinese hamster ovary cell line
Lectin bio‐layer interferometry for assessing product quality of Fc‐ glycosylated immunoglobulin G
Kinetic modeling as a tool to understand the influence of cell culture process parameters on the glycation of monoclonal
Real‐time quantification and supplementation of bioreactor amino acids to prolong culture time and maintain antibody pro
Multivariate data analysis of growth medium trends affecting antibody glycosylation
Interest of locally weighted regression to overcome nonlinear effects during in situ NIR monitoring of CHO cell culture
Effects of cysteine, asparagine, or glutamine limitations in Chinese hamster ovary cell batch and fed‐batch cultures
The effect of amino acid supplementation in an industrial Chinese Hamster Ovary process.
A class of low‐cost alternatives to kifunensine for increasing high mannose N‐linked glycosylation for monoclonal antibo
Quantification of glycated IgG in CHO supernatants: A practical approach
Impact of iron raw materials and their impurities on CHO metabolism and recombinant protein product quality
Modulation of high mannose levels in N-linked glycosylation through cell culture process conditions to increase antibody
Development of a miniature bioreactor model to study the impact of pH and DOT fluctuations on CHO cell culture performan
Modulation of nutrient precursors for controlling metabolic inhibitors by genome‐scale flux balance analysis
Modulating and optimizing Pluronic F‐68 concentrations and feeding for intensified perfusion Chinese hamster ovary cell
Use of single analytic tool to quantify both absolute N‐glycosylation and glycan distribution in monoclonal antibodies
Trace metal optimization in CHO cell culture through statistical design of experiments
An assessment of the impact of Raman based glucose feedback control on CHO cell bioreactor process development
An automated high inoculation density fed‐batch bioreactor, enabled through N‐1 perfusion, accommodates clonal diversity
Measurement and control of foam generation in a mammalian cell culture
Multivariate data analysis of process parameters affecting the growth and productivity of stable Chinese hamster ovary c
Use of spectroscopic process analytical technology for rapid quality evaluation during preparation of CHO cell culture m
Modeling of cell cultivation for monoclonal antibody production processes considering lactate metabolic shifts.
CHO stable pool fed‐batch process development of SARS ‐ CoV ‐2 spike protein production: Impact of aeration conditions a
Enhanced cell‐specific productivity through delayed supplementation of antioxidants in intensified processes
Minimizing batch‐to‐batch variability of a live virus vaccine by process analytical technologies
Scale-up of a monoclonal antibody CHO fed-batch production in stirred tank bioreactors: Effect of hydrodynamic condition
Dynamic pH profiles drive higher cell-specific and volumetric productivity.
In‐line monitoring of amino acids in mammalian cell cultures using raman spectroscopy and multivariate chemometrics mode
Elevated pCO<sub>2</sub> affects the lactate metabolic shift in CHO cell culture processes
A novel LED‐based 2D‐fluorescence spectroscopy system for in‐line bioprocess monitoring of Chinese hamster ovary cell cu
A novel LED‐based 2D‐fluorescence spectroscopy system for in‐line monitoring of Chinese hamster ovary cell cultivations
A statistical approach to improve compound screening in cell culture media
Expression of recombinant classical swine fever virus E2 glycoprotein by endogenous Txnip promoter in stable transgenic
Development, characterization, and application of a 2‐Compartment system to investigate the impact of pH inhomogeneities
Investigation of cell line specific responses to pH inhomogeneity and consequences for process design
Implementation of QbD strategies in the inoculum expansion of a mAb production process
Stress‐induced increase of monoclonal antibody production in CHO cells
Applying intensified design of experiments to mammalian cell culture processes
Optimization of a mAb production process with regard to robustness and product quality using quality by design principle
Employing QbD strategies to assess the impact of cell viability and density on the primary recovery of monoclonal antibo
Investigation and evaluation of a 3D‐printed optical modified cultivation vessel for improved scattered light measuremen
Calibration transfer for bioprocess Raman monitoring using Kennard Stone piecewise direct standardization and multivaria
Functional characterization of a SNP (F51S) found in human alpha 1‐antitrypsin
The effect of hyperosmolality application time on production, quality, and biopotency of monoclonal antibodies produced
Progress in fed-batch culture for recombinant protein production in CHO cells
pH excursions impact CHO cell culture performance and antibody N-linked glycosylation.
Process mapping and optimization study of CHO cell cultures for mAb production using Ambr® 250 high-throughput parallel
A semi-empirical glycosylation model of a camelid monoclonal antibody under hypothermia cell culture conditions
Establishment and optimization of a high-throughput mimic perfusion model in ambr® 15.
Combination of temperature shift and hydrolysate addition regulates anti-IgE monoclonal antibody charge heterogeneity in
Culture media optimization for Chinese hamster ovary cell growth and expression of recombinant varicella-zoster virus gl
Impact of DO, agitation, aeration and copper concentration on lactate metabolism and charge heterogeneity for monoclonal
Quantifying the impact of cell culture media on CHO cell growth and protein production.
A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering
Towards advanced bioprocess optimization: A multiscale modelling approach
QbD-guided pharmaceutical development of Pembrolizumab biosimilar candidate PSG-024 propelled to industry meeting primar
Development of hyper osmotic resistant CHO host cells for enhanced antibody production.
Sequential active learning for medium optimization in mAb production.
Cell culture media supplemented with raffinose reproducibly enhances high mannose glycan formation.
Assessment of fed-batch cultivation strategies for an inducible CHO cell line.
Understanding the effect of increased cell specific productivity on galactosylation of monoclonal antibodies produced us
Genome-scale metabolic analysis reveals enhanced metabolism and antioxidative stress response in perfusion cell culture
Quality matters – Is IgM production influenced by external process conditions?
Impact of temperature and pH on recombinant human IgM quality attributes and productivity.
Kinetic modeling: A tool for temperature shift and feeding optimization in cell culture process development.
Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/
Proteome-Wide Analysis of N-Glycosylation Stoichiometry Using SWATH Technology.
Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Pr
Glycoengineering Chinese hamster ovary cells: a short history
Defective mucin-type glycosylation on α-dystroglycan in COG-deficient cells increases its susceptibility to bacterial pr
Optimization of parameters affecting on CHO cell culture producing recombinant erythropoietin.
Enhancement of anti-TNFα monoclonal antibody production in CHO cells through the use of UCOE and DHFR elements in vector
Effects of various pine needle extracts on Chinese hamster ovary cell growth and monoclonal antibody quality
Non-targeted characterization of attributes affecting antibody-FcγRIIIa V158 (CD16a) binding via online affinity chromat
Nutrient supplementation strategy improves cell concentration and longevity, monoclonal antibody production and lactate
Debottlenecking Opportunities Clearer with a Bioprocessing 4.0 Perspective
C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system
Expression and Purification of Soluble, Glycosylated T‐cell Receptors in Chinese Hamster Ovary Cells
Analysis of coagulation factor IX in bioreactor cell culture medium predicts yield and quality of the purified product
CHOmpact: a reduced metabolic model of Chinese hamster ovary cells with enhanced interpretability
An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation
The microRNomes of Chinese Hamster Ovary (CHO) cells and their extracellular vesicles, and how they respond to osmotic a
Multi-omic characterization of antibody-producing CHO cell lines elucidates metabolic reprogramming and nutrient uptake
COSMIC-dFBA: A novel multi-scale hybrid framework for bioprocess modeling
Comparing Kinetic versus Stoichiometric Priorities in Hybrid Models of CHO Metabolism
A 0.7pArms Electrochemical Readout IC for Continuous Monitoring of Antibody Biologics in Upstream Biomanufacturing
N‐glycosylation regulates MET processing and signaling
Biopharmaceutical Manufacturing: Historical Perspectives and Future Directions
Impact Factors in the Process Development for Therapeutic Antibodies
Application of liquid chromatography-mass spectrometry-based protein and proteomic analytical approaches to chinese hams
Multi-omics analysis of Chinese hamster ovary cell-based biopharmaceutical production processes
FACTORS AFFECTING CHINESE HAMSTER OVARY CELL PROLIFERATION AND VIABILITY
Data-driven modeling of the degradation of recombinant proteins in Chinese hamster ovary cells
Designing a Strategy for pH Control to Improve CHO Cell Productivity in Bioreactor.
Glucose withdrawal-induced Chinese hamster ovary cells apoptosis and its potential role in process robustness assessment
Microevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactat
New high-throughput screening method for Chinese hamster ovary cell lines expressing low reduced monoclonal antibody lev
A ‘Coomassie for Carbohydrates” - novel methodology for rapid detection and quantitation of glycosylated IgGs on an SDS-
A hierarchical model combining process and Raman spectroscopic data for real-time monitoring of cell culture process
Enhancement of adalimumab expression in CHO cells by antioxidant small molecule additives and the underlying mechanism
Modulation of N-Glycosylation in Bispecific Antibody Biosimilars through Combined Modulators
Amino acid feeding reduces ammonia production through rearrangement of metabolic fluxes in central carbon metabolism of
Towards the Development of Automated Fed-Batch Cell Culture Processes at Microscale
Schistosoma mansoni alkaline phosphatase modulate platelet derived sphingosine-1-phosphate
An Improved Cell Culture Process for Production of Omalizumab
Production of Trimeric SARS-CoV-2 Spike Protein by CHO Cells for Serological COVID-19 Testing
Multi-omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer and
Constraint-based modeling and machine learning applications for analysis and optimization of fermentation parameters
Using MVDA with Stoichiometric Balances to Optimize Amino Acid Concentrations in Chemically Defined CHO Cell Culture Med
Identification of novel miRNA targets in CHO cell lines and characterization of their impact on protein N-glycosylation
Intracellular CHO cell metabolite profiling and in vivo monitoring of redox state unravel the effect of temperature down
Shortening the Biologics Clinical Timeline with a Novel Method for Generating Stable, High Producing Cell Pools and Clon
Inducible transgene expression in CHO cells using an artificial transcriptional activator with estrogen-binding domain
Calibration design for pharmaceutical bioprocesses: A novel approach for knowledge transfer in Design of Experiments
13C LABELING FOR CHO CELL METABOLISM TRACING AND MS BASED ANALYSIS FOR ADVANCED UPSTREAM CULTURE MONITORING TO SUPPORT C
Nucleotide and Nucleotide Sugar Analysis in Cell Extracts by Capillary Electrophoresis
Perfusion-Based Antibody Production in the Ambr<sup>®</sup> 250 Modular
Mathematical modelling for bioprocess understanding and optimisation
Characterization of Chinese Hamster Ovary Cell Performance with Pentanoic Acid and N-Acetyl Cysteine Treatment
WITHDRAWN
Evaluation of feed strategy for high quality biosimilar IgG production in CHO cell fed-batch process
Novel Platforms for Large-Scale Adherent Culture of Mammalian Cells
Expanding the understanding of viral tropism by characterizing the N-glycomic profiles of transducible cell lines and ti
Enhancing Recombinant Monoclonal Antibody Production in CHO Cell Cultures: Leveraging the Power of Multivariate Analysis
Semi-Automated Glycoproteomic Data Analysis of LC-MS Data Using GlycopeptideGraphMS in Process Development of Monoclonal
Optimization of human interferon beta protein expression in Chinese hamster ovary cells
Investigation of the influence of large scale occurring pH heterogeneities on CHO cells
Optimization of Chinese hamster ovary cell expression-based Fc fusion protein preparation process
COMPREHENSIVE EVALUATION OF EXPRESSION PLATFORM: CHERRY PICKING THE ‘RIGHT’ TO ACCOMPLISH THE ‘BEST
Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells
Purification and Analytics of a Monoclonal Antibody from Chinese Hamster Ovary Cells Using an Automated Microbioreactor
Rapid Antibody Glycoengineering in Chinese Hamster Ovary Cells
SPRi cytometry: sensitively sensing the sensitive side of cells
Choice of Host Cell Line Is Essential for the Functional Glycosylation of the Fc Region of Human IgG1 Inhibitors of Infl
Improvement of Recombinant Proteins Production by Inducing Mitochondrial Biogenesis in CHO Cell Culture
Amélioration de la production et de la qualité des protéines thérapeutiques recombinantes produites en culture en mode c
Development and application of quantitative liquid chromatography – mass spectrometry techniques to facilitate enhanced
Development of DNA and recombinant vaccines against toxoplasma gondii infection / Ching Xiao Teng
Investigating Low Culture Temperature and Low Media pH of Two Chinese Hamster Ovary (CHO) Cell Lines with Next Generatio
MicroRNA Profiling and Engineering of CHO Cell Lines Stably Expressing Difficult-to-Express Lysosomal Protein
microRNAs as potential tools for ‘miR’aculous CHO cell phenotypes in Bioprocessing systems
Profiling the dynamic changes in the phosphoproteome of Chinese hamster ovary cells
Single cell analysis and quantitative modelling of ion concentrations and dielectric properties of Chinese hamster ovary
Small scale bioprocess optimization using soft sensors
Supplementation Strategies for Tuning Glycosylation of Monoclonal Antibodies and Enhancing Growth in Mammalian Cell Cult
Systematic Approaches to Identification of Dynamic Flux Balance Models
Animal Cell Expression Systems.
Quantification of the dynamics of population heterogeneities in CHO cultures with stably integrated fluorescent markers
Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture super
O-Glycoproteomic analysis of engineered heavily glycosylated fusion proteins using nanoHILIC-MS
A control strategy to investigate the relationship between specific productivity and high-mannose glycoforms in CHO cell
Metabolic characterization of a CHO cell size increase phase in fed-batch cultures
Hyperosmolality in CHO cell culture: effects on the proteome
Exploring metabolic effects of dipeptide feed media on CHO cell cultures by in silico model-guided flux analysis
Effects of autophagy-inhibiting chemicals on sialylation of Fc-fusion glycoprotein in recombinant CHO cells
Effects of process intensification on homogeneity of an IgG1:κ monoclonal antibody during perfusion culture
Explainable AI for CHO cell culture media optimization and prediction of critical quality attribute
Characterization and design of dipeptide media formulation for scalable therapeutic production
N-Glycosylation modulators for targeted manipulation of glycosylation for monoclonal antibodies
Investigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critic
On-line glucose monitoring by near infrared spectroscopy during the scale up steps of mammalian cell cultivation process
Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch
Pre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensificati
Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation: applied to an i
Compartment-specific metabolome labeling enables the identification of subcellular fluxes that may serve as promising me
Exploring the limits of conventional small-scale CHO fed-batch for accelerated on demand monoclonal antibody production
Genome-scale modeling of Chinese hamster ovary cells by hybrid semi-parametric flux balance analysis
Enhancement of recombinant human IL-24 (rhIL-24) protein production from site-specific integrated engineered CHO cells b
Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing uni
Soft sensor for monitoring biomass subpopulations in mammalian cell culture processes
A simple method to determine evaporation and compensate for liquid losses in small-scale cell culture systems
Differential expression of miRNAs and functional role of mir-200a in high and low productivity CHO cells expressing an F
Selection of chemically defined media for CHO cell fed-batch culture processes
Construction of a novel kinetic model for the production process of a CVA6 VLP vaccine in CHO cells
Evaluating the impact of media and feed combinations on CHO cell culture performance and monoclonal antibody (trastuzuma
Model-Based Methods in the Biopharmaceutical Process Lifecycle
PID controls: the forgotten bioprocess parameters
Mucin 21 confers resistance to apoptosis in an O-glycosylation-dependent manner
The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secre
Application of maltose as energy source in protein-free CHO-K1 culture to improve the production of recombinant monoclon
Chromophore pre-maturation for improved speed and sensitivity of split-GFP monitoring of protein secretion
Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation
Investigating the influence of physiologically relevant hydrostatic pressure on CHO cell batch culture
Developing a medium combination to attain similar glycosylation profile to originator by DoE and cluster analysis method
High shear resistance of insect cells: the basis for substantial improvements in cell culture process design
Exploring synthetic biology for the development of a sensor cell line for automated bioprocess control
Development of a stable antibody production system utilizing an Hspa5 promoter in CHO cells
Tyrosine O-sulfation proteoforms affect HIV-1 monoclonal antibody potency
Microevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactat
Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and ge
Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombin
Comprehensive modeling of cell culture profile using Raman spectroscopy and machine learning
Viable cell density as an indicator for dynamic feeding strategy in fed-batch and perfusion CHO cell culture
Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified product
Simplifying glycan monitoring of complex antigens such as the SARS-CoV-2 spike to accelerate vaccine development
Modifying the glycosylation profile of SARS-CoV-2 spike-based subunit vaccines alters focusing of the humoral immune res
Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion
A Systematic Approach to Time-series Metabolite Profiling and RNA-seq Analysis of Chinese Hamster Ovary Cell Culture
Proteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO Cells
Evaluation and use of disaccharides as energy source in protein-free mammalian cell cultures
<i>N</i>-Glycosylation profiling of intact target proteins by high-resolution mass spectrometry (MS) and glycan analysis
Real-time characterization of mammalian cell culture bioprocesses by magnetic sector MS
Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster
Enzyme capacity-based genome scale modelling of CHO cells
A recombinant gp145 Env glycoprotein from HIV-1 expressed in two different cell lines: effects on glycosylation and anti
Production of Trimeric SARS-CoV-2 Spike Protein by CHO Cells for Serological COVID-19 Testing
An integrated strategy reveals complex glycosylation of erythropoietin using top-down and bottom-up mass spectrometry
Structural and functional characterization of SARS-CoV-2 RBD domains produced in mammalian cells
Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins
Sialic acid and fucose residues on the SARS-CoV-2 receptor binding domain modulate IgG reactivity
Model-based intensification of CHO cell cultures: one-step strategy from fed-batch to perfusion
Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/
Automated Workflow for Instant Labeling and Real-Time Monitoring of Monoclonal Antibody N-Glycosylation
On-line reoptimization of mammalian fed-batch culture using a nonlinear model predictive controller
Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data-driven and model-guided anal
Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch a
Nicotinamide reverses the Warburg effect in Chinese hamster ovary cell culture
A Hybrid Modeling Framework for Predictive Digital Twins of CHO Cell Culture
HIV-1 vaccine design through minimizing envelope metastability
Implementation of Design of Experiments (DOE) for Optimization of Feeding Strategy and Glyco-Engineering of Trastuzumab
Multiplex secretome engineering enhances recombinant protein production and purity
Choice of host cell line is essential for the functional glycosylation of the fragment crystallizable (Fc) region of hum
A metabolic network-based approach for developing feeding strategies for CHO cells to increase monoclonal antibody produ
Visualization of the HIV-1 Env Glycan Shield Across Scales
CO&lt;sub&gt;2&lt;/sub&gt; Control Strategy for Large-Scale Cell Culture Bioreactor Operation
Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with
Development and biological activity of long-acting recombinant human interferon-α2b
Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cell
Mapping the molecular basis for growth related phenotypes in industrial producer CHO cell lines using differential prote
Roles of N-linked and O-linked glycosylation sites in the activity of equine chorionic gonadotropin in cells expressing
Abstracts from the 25th European Society for Animal Cell Technology Meeting: Cell Technologies for Innovative Therapies
Abstracts from the 26th European Society for Animal Cell Technology Meeting - Cell culture technologies: bridging academ
Scale-up of CHO cell cultures: from 96-well-microtiter plates to stirred tank reactors across three orders of magnitude
SWATH-MS insights on sodium butyrate effect on mAbs production and redox homeostasis in CHO cells
Responses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabol
Uridine modulates monoclonal antibody charge heterogeneity in Chinese hamster ovary cell fed-batch cultures
Cell-culture growth conditions resulting in the oxidation of a recombinant antigen-binding fragment
Development of an intensified fed-batch production platform with doubled titers using N-1 perfusion seed for cell cultur
Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclo
Similarity assessment by multivariate statistics method based on the distance between biosimilar and originator
Seed train process intensification strategy offers potential for rapid, cost-effective scale-up of biosimilars manufactu
Specific Biological Activity of Equine Chorionic Gonadotropin (eCG) Glycosylation Sites in Cells Expressing Equine Lutei
Maximum entropy and population heterogeneity in continuous cell cultures
Effect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human T
Understanding and Controlling Sialylation in a CHO Fc-Fusion Process
Metabolic engineering of CHO cells for the development of a robust protein production platform
Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells
Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production
High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat
Therapeutic Fc fusion protein misfolding: A three-phasic cultivation experimental design
A recombinant gp145 Env glycoprotein from HIV-1 expressed in two different cell lines: Effects on glycosylation and anti
Gene editing in CHO cells to prevent proteolysis and enhance glycosylation: Production of HIV envelope proteins as vacci
Evidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies prod
Population balance modelling captures host cell protein dynamics in CHO cell cultures
Induction of heat shock protein expression in SP2/0 transgenic cells and its effect on the production of monoclonal anti
Process transfer and optimization of Chinese hamster ovary cell cultivation for monoclonal antibody production
Optimization of transient protein production by chemically transfected CHO suspension cells
Genome-editing techniques to increase the therapeutic efficacy of monoclonal antibodies
Glycosylation Flux Analysis of Immunoglobulin G in Chinese Hamster Ovary Perfusion Cell Culture
A ’Coomassie for Carbohydrates” – Novel Methodology for Rapid Detection and Quantitation of Glycosylated IgGs on an SDS-
Deciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computa
Similarity Assessment by Multivariate Statistics Method Based on Distance Between Biosimilar and Originator
Chinese Hamster Ovary Cell Line Development via Imaging Flow Cytometry and Directed Evolution
Antibody Productivity of CHO Cells is Altered by ER Stress Tolerance of the Host Cell
Ouantitative Proteomic Analysis of Cellular Responses to a Designed Amino Acid Feed in a Monoclonal Antibody Producing C
Oxygen Uptake Rate Soft-Sensing via Dynamic kLa Computation: Cell Volume and Metabolic Transition Prediction in Mammalia
Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Producti
Decoupling Growth and Protein Production in CHO Cells: A Targeted Approach
Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling
Advances of Glycometabolism Engineering in Chinese Hamster Ovary Cells
Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Sp
Strategies and Considerations for Improving Recombinant Antibody Production and Quality in Chinese Hamster Ovary Cells
Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells
Application of bioreactor technology for cell culture-based viral vaccine production: Present status and future prospect
A novel approach to noninvasive monitoring of dissolved carbon dioxide in small-scale cell culture processes
Boosting Productivity for Advanced Biomanufacturing by Re-Using Viable Cells
Enhancing and stabilizing monoclonal antibody production by Chinese hamster ovary (CHO) cells with optimized perfusion c
A novel hybrid bioprocess strategy addressing key challenges of advanced biomanufacturing
Development of a scalable single process for producing SARS-CoV-2 RBD monomer and dimer vaccine antigens
Advancements in CHO metabolomics: techniques, current state and evolving methodologies
Modulating antibody N-glycosylation through feed additives using a multi-tiered approach
Cell clone selection—impact of operation modes and medium exchange strategies on clone ranking
Boost dynamic protocols for producing mammalian biopharmaceuticals with intensified DoE—a practical guide to analyses wi
A Linkage-specific Sialic Acid Labeling Strategy Reveals Different Site-specific Glycosylation Patterns in SARS-CoV-2 Sp
Over-expression of a Codon Optimized Yeast Cytosolic Pyruvate Carboxylase (PYC2) in CHO Cells for an Augmented Lactate M
Risk-Based Control Strategies of Recombinant Monoclonal Antibody Charge Variants
Exploring Parametric and Mechanistic Differences between Expi293FTM and ExpiCHO-STM Cells for Transient Antibody Product
Impact of Acetylated and Non-Acetylated Fucose Analogues on IgG Glycosylation
Rapid Identification of Chinese Hamster Ovary Cell Apoptosis and Its Potential Role in Process Robustness Assessment
Temperature Upshifts in Mammalian Cell Culture: A Suitable Strategy for Biosimilar Monoclonal Antibodies?
Triple Space-Time Yield in Discontinuous Antibody Biomanufacturing by Combination of Synergetic Process Intensification
Deciphering Metabolic Pathways in High-Seeding-Density Fed-Batch Processes for Monoclonal Antibody Production: A Computa
Integration Approaches to Model Bioreactor Hydrodynamics and Cellular Kinetics for Advancing Bioprocess Optimisation
Metabolic Control in Mammalian Fed-Batch Cell Cultures for Reduced Lactic Acid Accumulation and Improved Process Robustn
Comparison of Three Glycoproteomic Methods for the Analysis of the Secretome of CHO Cells Treated with 1,3,4-O-Bu3ManNAc
Improved Time Resolved KPI and Strain Characterization of Multiple Hosts in Shake Flasks Using Advanced Online Analytics
Optimization and Scale-Up of Fermentation Processes Driven by Models
Screening of Membrane Protein Production by Comparison of Transient Expression in Insect and Mammalian Cells
Hybrid Modelling and Multi- Parametric Control of Bioprocesses
Clever Experimental Designs: Shortcuts for Better iPSC Differentiation
Metabolic Profiling of CHO Cells during the Production of Biotherapeutics
Stability and Requirement for Thiamin in a Cell Culture Feed Used to Produce New Biological Entities
High-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loo
Cell-Sonar, a Novel Method for Intracellular Tracking of Secretory Pathways
Model Predictive Control—A Stand Out among Competitors for Fed-Batch Fermentation Improvement
Dynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Ada
Methods for Using Small Non-Coding RNAs to Improve Recombinant Protein Expression in Mammalian Cells
A Simple Method to Reduce both Lactic Acid and Ammonium Production in Industrial Animal Cell Culture
Osmolality Effects on CHO Cell Growth, Cell Volume, Antibody Productivity and Glycosylation
Recombinant Human CD19 in CHO-K1 Cells: Glycosylation Patterns as a Quality Attribute of High Yield Processes
Continuous Feeding Reduces the Generation of Metabolic Byproducts and Increases Antibodies Expression in Chinese Hamster
Sensor Selection and State Estimation of Continuous mAb Production Processes
Using Metabolomics to Identify Cell Line-Independent Indicators of Growth Inhibition for Chinese Hamster Ovary Cell-Base
Hyperosmolarity Triggers the Warburg Effect in Chinese Hamster Ovary Cells and Reveals a Reduced Mitochondria Horsepower
A Metabolomics Approach to Increasing Chinese Hamster Ovary (CHO) Cell Productivity
Model-Based Optimization of a Fed-Batch Bioreactor for mAb Production Using a Hybridoma Cell Culture
Quantitative N-Glycan Profiling of Therapeutic Monoclonal Antibodies Performed by Middle-Up Level HILIC-HRMS Analysis
Monitoring of Nutrients, Metabolites, IgG Titer, and Cell Densities in 10 L Bioreactors Using Raman Spectroscopy and PLS
New Insights from Locally Resolved Hydrodynamics in Stirred Cell Culture Reactors
Modern Sensor Tools and Techniques for Monitoring, Controlling, and Improving Cell Culture Processes
Towards Autonomous Process Control—Digital Twin for CHO Cell-Based Antibody Manufacturing Using a Dynamic Metabolic Mode
Insights into the Impact of Rosmarinic Acid on CHO Cell Culture Improvement through Transcriptomics Analysis
Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biop
Identification of Cell Culture Factors Influencing Afucosylation Levels in Monoclonal Antibodies by Partial Least-Square
An Investigation into the Metabolic Differences between Conventional and High Seeding Density Fed-Batch Cell Cultures by
BioDT: An Integrated Digital-Twin-Based Framework for Intelligent Biomanufacturing
3D Printed, Single-Use Bioreactor with Integrated Inline Sensors for Microbial and Mammalian Cell Cultivation—A Case Stu
A Framework for the Development of Integrated and Computationally Feasible Models of Large-Scale Mammalian Cell Bioreact
Sequential Parameter Estimation for Mammalian Cell Model Based on In Silico Design of Experiments
Glycosylation Flux Analysis of Immunoglobulin G in Chinese Hamster Ovary Perfusion Cell Culture
Accelerating Biologics Manufacturing by Upstream Process Modelling
Strategic Framework for Parameterization of Cell Culture Models
Prediction of N-linked Glycoform Profiles of Monoclonal Antibody with Extracellular Metabolites and Two-Step Intracellul
Single-Use Printed Biosensor for L-Lactate and Its Application in Bioprocess Monitoring
Dynamic Optimization of a Fed-Batch Nosiheptide Reactor
Effect of Sialic Acid on Mammalian Cell Culture and Protein Expression: A Potential Productivity Enhancer for Biopharmac
Subspace Based Model Identification for an Industrial Bioreactor: Handling Infrequent Sampling Using Missing Data Algori
Towards Autonomous Operation by Advanced Process Control—Process Analytical Technology for Continuous Biologics Antibody
mAb Production Modeling and Design Space Evaluation Including Glycosylation Process
Off-Gas-Based Soft Sensor for Real-Time Monitoring of Biomass and Metabolism in Chinese Hamster Ovary Cell Continuous Pr
Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors
Halfway to Automated Feeding of Chinese Hamster Ovary Cells
Optimizing the Production of gp145, an HIV-1 Envelope Glycoprotein Vaccine Candidate and Its Encapsulation in Guanosine
Strategies Used in Manufacturing Processes to Drive and Control Mammalian Cells to Undergo a Lactate Metabolic Shift
Model-Based Optimization of a Fed-Batch Bioreactor for mAb Production Using a Hybridoma Cell Culture
Clustering and curation of electropherograms: an efficient method for analyzing large cohorts of capillary electrophores
A Symbolic and Statistical Learning Framework to Discover Bioprocessing Regulatory Mechanism: Cell Culture Example
Challenges and Emerging Technologies in Biomanufacturing of Monoclonal Antibodies (mAbs)
Perspective Chapter: Advanced Process Control and Automation with Special Focus on Emerging Continuous Bioprocessing
Development, Engineering and Biological Characterization of Stirred Tank Bioreactors
Microbioreactors and Perfusion Bioreactors for Microbial and Mammalian Cell Culture
Modeling, estimation, and control of glycosylation in monoclonal antibodies produced in CHO cells
Optimization of Culture Conditions to Improve Follicle-Stimulating Hormone Production by CHO-DG44 Cells in Serum-Free Me
A dynamic metabolic flux analysis (DMFA) model for performance predictions of diverse CHO cell culture process modes and