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Tick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock.
Protein phosphatase 2A activators reverse age-related behavioral changes by targeting neural cell senescence.
Deletion of SA β-Gal+ cells using senolytics improves muscle regeneration in old mice.
Emerging rejuvenation strategies-Reducing the biological age.
Generalized low levels of serum N‐glycans associate with better health status
Chromatin‐transcription interface: The secret of eternal youth?
Intestinal stem cell aging at single-cell resolution: Transcriptional perturbations alter cell developmental trajectory
Exercise reduces circulating biomarkers of cellular senescence in humans.
Youthful and age-related matreotypes predict drugs promoting longevity.
Age‐dependent nuclear lipid droplet deposition is a cellular hallmark of aging in <i>Caenorhabditis elegans</i>
Effect of peripheral cellular senescence on brain aging and cognitive decline.
Cytochrome b5 reductase 3 overexpression and dietary nicotinamide riboside supplementation promote distinctive mitochond
Translatability of life-extending pharmacological treatments between different species.
U‐shaped association between sleep duration and biological aging: Evidence from the UK Biobank study
Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species
Senolytic treatment attenuates immune cell infiltration without improving IAV outcomes in aged mice.
AI-Driven Identification of Exceptionally Efficacious Polypharmacological Compounds That Extend the Lifespan of Caenorha
Targeting cellular senescence with senotherapeutics: senolytics and senomorphics.
Rapamycin Reverses the Hepatic Response to Diet‐Induced Metabolic Stress That Is Amplified by Aging
Regulation of inflammation as an anti‐aging intervention
Recent advances in biomarkers for senescence: Bridging basic research to clinic.
Challenges in anti-aging medicine-trends in biomarker discovery and therapeutic interventions for a healthy lifespan.
Senotherapy preserves resilience in aging.
Methionine restriction and life-span control.
A study of the molecular mechanism of quercetin and dasatinib combination as senolytic in alleviating age-related and ki
The senotherapeutic nicotinamide riboside raises platelet nicotinamide adenine dinucleotide levels but cannot prevent st
Metabolic regulation of behavior by the intestinal enzyme FMO-2.
Manipulating Cellular Energetics to Slow Aging of Tissues and Organs
Metabolic reprogramming: a bridge between aging and tumorigenesis
Small Molecule from Natural Phytochemical Mimics Dietary Restriction by Modulating FoxO3a and Metabolic Reprogramming
A Senomorphlytic Three-Drug Combination Discovered in Salsola collina for Delaying Aging Phenotypes and Extending Health
Biomarkers of Cellular Senescence and Aging: Current State-of-the-Art, Challenges and Future Perspectives.
Insulin as an Accelerator and Brake of Aging: From Molecular Landscape to Clinical Interventions.
The biology of frailty in humans and animals: Understanding frailty and promoting translation
Integrative Omics Reveal Female-Specific Benefits of p16+ Cell Clearance in Aging Mice.
Effect of geroprotectors on metabolic health and cognitive function in a mouse model of Alzheimer’s disease
Nurturing longevity through natural compounds: Where do we stand, and where do we go?
How can aging be reversed? Exploring rejuvenation from a damage‐based perspective
Glucose 6‐P dehydrogenase delays the onset of frailty by protecting against muscle damage
Aging mechanisms—A perspective mostly from Drosophila
Protein Turnover in Aging and Longevity
The Aging Metabolome-Biomarkers to Hub Metabolites.
Obesity, Senescence, and Senolytics.
Biomarkers of ageing: Current state‐of‐art, challenges, and opportunities
Aging Reduces an ERRalpha-Directed Mitochondrial Glutaminase Expression Suppressing Glutamine Anaplerosis and Osteogenic
Aging: Mechanisms, Measures, and Interventions
A Binary siRNA-Loaded Tetrahedral DNA Nanobox for Synergetic Anti-Aging Therapy.
Aging Biomarkers and Novel Targets for Anti-Aging Interventions.
The Use of Metformin to Increase the Human Healthspan.
Aspirin as a Potential Geroprotector: Experimental Data and Clinical Evidence.
Intermittent Fasting as an Anti-Aging Strategy
Gerosuppressive and Senolytic Nutrients
AMPK as a Pro-longevity Target.
Intermittent Fasting-Dietary Restriction as a Geroprotector
Unlocking the Potential of Senolytic Compounds: Advancements, Opportunities, and Challenges in Ageing-Related Research.
[Skin aging-cellular senescence : What is the future?].
Nutrition interventions for healthy ageing across the lifespan: a conference report
Alternative splicing in aging and longevity.
Metformin as a geroprotector: experimental and clinical evidence
The role of NAD and NAD precursors on longevity and lifespan modulation in the budding yeast, Saccharomyces cerevisiae.
Geroprotective effects of GdVO4:Eu3 + nanoparticles, metformin and calorie restriction in male rats with accelerated agi
Mitochondria-targeted senotherapeutic interventions.
“Development of gerontology would be more effective under governmental support”: an interview with Vladimir N. Anisimov
Identification of resibufogenin, a component of toad venom, as a novel senolytic compound in vitro and for potential ski
Targeting the epigenetically older individuals for geroprotective trials: the use of DNA methylation clocks.
Application potential of senolytics in clinical treatment.
Calorie restriction mimetics against aging and inflammation.
Influence of a diet with potential geroprotectors on blood biochemistry and aging-associated markers in domestic cats: a
Realistic expectations for changes to average human lifespan in the near future.
The Role of DNA Damage and Nutritional Interventions in Aging in Progeroid Mice
Senotherapeutic repurposing of metformin for age-related diseases and their signaling pathways.
Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in g
A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse
Human geroprotector discovery by targeting the converging subnetworks of aging and age-related diseases.
Pterocarpus marsupium extract extends replicative lifespan in budding yeast.
Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neuro
Geroprotective interventions in the 3xTg mouse model of Alzheimer's disease.
Testing the evidence that lifespan-extending compound interventions are conserved across laboratory animal model species
Comprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n = 546) of geriatri
Long-term dasatinib plus quercetin effects on aging outcomes and inflammation in nonhuman primates: implications for sen
Blazing a trail for the clinical use of rapamycin as a geroprotecTOR.
The regeneration model of aging and its practical implications
[Key Molecular Mechanisms of Aging, Biomarkers, and Potential Interventions].
Targeting glucose metabolism for healthy aging.
Leveraging budding yeast Saccharomyces cerevisiae for discovering aging modulation substances for functional food
Why do sexes differ in lifespan extension? Sex-specific pathways of aging and underlying mechanisms for dimorphic respon
Multiple Roles of Mitochondria in Aging Processes
Integrating evolutionary theory into a framework for the mechanistic evaluation of candidate anti-aging interventions
Evidence that C/EBP-β LAP Increases Fat Metabolism and Protects Against Diet-Induced Obesity in Response to mTOR Inhibit
Sirtuin activators as an anti-aging intervention for longevity
Study of the possibility of using metformin by intranasal administration for the correction of behavioral and cognitive
RUSS-AGE: developed research protocol for the creation of Russian biological age calculators
Sarcopenia and Muscle Aging: A Brief Overview
Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging.
Recent Advances in Anti-Aging Medicine.
Longevity interventions temporally scale healthspan in Caenorhabditis elegans.
Applying Longevity and Anti-Aging Research to Athletic Performance: Strategies to Extend Playing Careers, Reduce Injury
Discrimination of Normal from Slow-Aging Mice by Plasma Metabolomic and Proteomic Features Datasets
Discrimination of Normal from Slow-Aging Mice by Plasma Metabolomic and Proteomic Features Datasets
The Theory of Medical Irreversibility
The Theory of Medical Irreversibility
ANALYSIS OF SCIENTIFIC SOURCES REGARDING THEORIES OF AGING AND LONGEVITY
Two genes of interest from comparative longevity genomics: FAM126B and OBSCN
El envejecimiento: ¿Podemos frenarlo? Autofagia/Nutrición. Reprogramación Celular Segunda Parte
Replication Data for: The Biohacking Shadow Market: Constructing Legitimacy and Shaping Institutional Voids in the GCC
Multi-level remodeling of transcriptional landscapes in aging and longevity.
Cell Nonautonomous Regulation of Longevity and Behavior
Responses to Many Anti-Aging Interventions Are Sexually Dimorphic.
Drugs with Senolytic Activity: Prospects and Possible Limitations
Translational longevity medicine: a Swiss perspective in an ageing country
CITP Automated Lifespan Machine (ALM) SOPs
An Inflammatory and Quiescent HSC Subpopulation Expands with Age in Humans.
Current Understanding of p53-Dependent Cellular Senescence in Health Disparities: Molecular Insights and Public-Health S
Glycine and aging: Evidence and mechanisms.
Artificial intelligence for aging and longevity research: Recent advances and perspectives.
The immunosenescence clock: A new method for evaluating biological age and predicting mortality risk.
Validation requirements for AI-based intervention-evaluation in aging and longevity research and practice.
Hallmarks of aging: A user's guide for comparative biologists.
Deep aging clocks: AI-powered strategies for biological age estimation.
Current nutritional and pharmacological anti-aging interventions.
In-silico evaluation of aging-related interventions using omics data and predictive modeling.
The impact of short-lived controls on the interpretation of lifespan experiments and progress in geroscience - Through t
Characterization of craniofacial tissue aging in genetically diverse HET3 male mice with longevity treatment of 17-alpha
Pan-mTOR inhibitors sensitize the senolytic activity of navitoclax via mTORC2 inhibition-mediated apoptotic signaling.
Pursuing healthy aging and longevity through natural product and stem cell-driven rejuvenation.
Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission.
Effects of two longevity interventions, calorie restriction and rapamycin treatment, on the kynurenine-aryl hydrocarbon
Frentizole derivatives with mTOR inhibiting and senomorphic properties.
Role of epigenetics in the regulation of skin aging and geroprotective intervention: A new sight.
Implication of cellular senescence in the progression of chronic kidney disease and the treatment potencies.
Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions.
Rejuvenation of the Aging Heart: Molecular Determinants and Applications.
Enhanced cellular longevity arising from environmental fluctuations.
Rapamycin Extends Life Span in Apc Colon Cancer FAP Model
Distinct longevity mechanisms across and within species and their association with aging.
Biomarkers of aging for the identification and evaluation of longevity interventions.
SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.
The anti-aging drug Senolytics alleviates vascular endothelial cell senescence by antagonizing the JPX-BRD4-p65 complex.
Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging.
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.
Design and optimization of piperlongumine analogs as potent senolytics.
Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.
Quantitative Translation of Dog-to-Human Aging by Conserved Remodeling of the DNA Methylome.
Apelin/APJ system: A novel promising target for anti-aging intervention.
Mitochondrial regulator PGC-1a-Modulating the modulator.
A nutrigeroscience approach: Dietary macronutrients and cellular senescence.
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation.
Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.
Hallmarks of aging and immunosenescence: Connecting the dots.
Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice.
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells.
Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal system
Cellular Senescence: A Translational Perspective
Identification of miR-106b-5p as a senolytic miRNA.
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies.
Concept of Human Aging Biomarkers.
An Incipient Revolution in the Testing of Anti-aging Strategies.
Potential Geroprotectors - From Bench to Clinic.
SAT0053 Identification of novel drugs with senolytic activity as osteoarthritis therapeutics
GDF11 protein as a geroprotector
Fisetin, a potential caloric restriction mimetic, attenuates senescence biomarkers in rat erythrocytes.
The Genomics of Aging at the Single-Cell Scale.
The Impact of Environmental Factors in Influencing Epigenetics Related to Oxidative States in the Cardiovascular System
Gengnianchun Extends the Lifespan of <i>Caenorhabditis elegans</i> via the Insulin/IGF‐1 Signalling Pathway
Senotherapy Protects against Cisplatin-Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage
Abstract 991: Unraveling the role of nicotinamide adenine dinucleotide precursors in pancreatic cancer biology
Frailty Assessment in Animal Models
Abstract 603: Repurposing the plant-derived compound apigenin in anticancer and antiaging pipelines
Ex vivo Anti-Senescence Activity of N-Acetylcysteine in Visceral Adipose Tissue of Obese Volunteers
Are Senolytic Agents Guilty of Overkill or Inappropriate Age Discrimination?
Elixir of Life
Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases
Calorie restriction protects neural stem cells from age-related deficits in the subventricular zone
No limit to maximal lifespan in humans: how to beat a 122-year-old record.
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An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies
Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis
Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes
Multiomic clocks to predict phenotypic age in mice.
Senolytics Enhance the Longevity of Caenorhabditis elegans by Altering Betaine Metabolism.
Resilience in Aging Mice
Caloric Restriction and Healthy Life Span: Frail Phenotype of Nonhuman Primates in the Wisconsin National Primate Resear
Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index.
Development of a Rat Clinical Frailty Index
Metformin Suppresses Monocyte Inflammation and Metabolic Reprogramming by SARS-CoV-2 Spike Protein
Bring Back the Rat!
Mechanistic target of rapamycin signaling in mouse models of accelerated aging
Can We Simplify Aging?
Age‐related alterations in gait function in freely moving male C57BL/6 mice: translational relevance of decreased cadenc
CONVERGENT CELL NONAUTONOMOUS PATHWAYS REWIRE METABOLISM TO SLOW AGING
Role of Physiological Resilience in Aging: Challenges and Opportunities
Anti-Aging Interventions Targeting the Hallmarks of Aging
Recombinant SARS-CoV-2 Spike Protein Mediates Glycolytic and Inflammatory Activation in Human Monocytes
Mammalian Co-methylation Network Analysis of Species Characteristics
ROBUST LONGEVITY EFFECTS OF NOVEL COMPOUNDS TESTED BY THE CAENORHABDITIS INTERVENTION TESTING PROGRAM
COMPARATIVE TRANSCRIPTOMICS AND PROTEOMICS ACROSS SPECIES
DELETION OF THROMBOSPONDIN-1 PRESERVES HEMATOPOIETIC STEM CELL HEALTHSPAN DURING AGING
STRATEGIES OF LIFESPAN REGULATION WITHIN AND ACROSS SPECIES
LEVERAGING THE NDUFS4-/- MOUSE AS A PLATFORM FOR TESTING LONGEVITY INTERVENTIONS
- **DOI:** 10.1093/geroni/igad104.0594 - **Authors:** Shin-ichiro Imai - **Year:** 2023 - **Journal:** Innovation in agi
ANTIDIABETIC THERAPIES METFORMIN AND TRODUSQUEMINE MODULATE MIRNAS INVOLVED WITH LIVER METABOLISM
ANTI-AGING COMPOUNDS METFORMIN AND THIOFLAVIN T CAN ACT ON GENETICALLY DIVERSE, PROTEOSTASIS-COMPROMISED STRAINS
Can We Simplify Aging?
PERIODIC FASTING MIMICKING DIET, LONGEVITY, AND DISEASE
MULTIOMIC SYSTEMS ANALYSIS OF LIFESPAN-EXTENDING INTERVENTIONS IN MOUSE TISSUES
The Impact of Short-Term Dietary Restriction on Stem Cell Function
Interconnections of Hypoxia and Aging in Long-Lived Species
FROM THE NATHAN SHOCK CENTERS COORDINATING CENTER: BIOLOGY OF AGING FOR NONBIOLOGISTS
MAPPING LONGEVITY PATHWAYS THROUGH MITOCHONDRIAL DYSFUNCTION: ROLES OF THE MICROBIOME AND METABOLISM IN AGING
THE CONTRIBUTION OF THE MICROBIOME TO THE AGING PROCESS
SEROTONIN AND DOPAMINE CIRCUITS MODULATE AGING IN RESPONSE TO FOOD CUES AND AVAILABILITY
FMO-4 SLOWS AGING DOWNSTREAM OF MTOR AND DR THROUGH ER TO MITOCHONDRIA CALCIUM SIGNALING
NEW TOOL ENHANCES DETECTION OF LIFE-EXTENDING INTERVENTIONS BY DELINEATING THEIR TEMPORAL EFFICACY
Crowdsourced Drug Discovery Approach Identifies BET Inhibitors As Novel Geroprotectors Promoting Healthy Aging
ACCELERATED PACE OF BIOLOGICAL AGING IN PARTICIPANTS WITH LOW LEVELS OF SELENIUM BIOMARKERS IN BERLIN AGING STUDY II
When What You See Isn’t What You Get: How Environmental Cues Modify Longevity and Behavior
NEW TOOL ENHANCES DETECTION OF LIFE-EXTENDING INTERVENTIONS BY DELINEATING THEIR TEMPORAL EFFICACY
POSTTRANSLATIONAL MODULATION OF MACROMOLECULES DURING AGING
Targeting Vascular Aging in Progeria by mTOR Inhibitors from Multi-Omics Screening
MECHANISMS OF LONGEVITY: LESSONS FROM LONG-LIVED MAMMALS
THE MOUSE CLINICAL FRAILTY INDEX AS AN OUTCOME AND MODULATOR OF DRUG THERAPY
FRAILTY AND BIOLOGICAL AGE IN ANIMAL MODELS
#2330 Fisetin supplement ameliorates aging related changes in the kidney
OLD AGE PHARMACOEPIDEMIOLOGY: SETTING THE SCENE
Metabolic regulation in the senescence process of stem cells.
AgeAnnoMO: a knowledgebase of multi-omics annotation for animal aging.
Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging.
Targeting Alternative Splicing for Reversal of Cellular Senescence in the Context of Aesthetic Aging.
Emerging strategies for biological age reversal
Geroprotectors: A role in the treatment of frailty.
Exploring vascular aging in ERCC1-deficient mice and progressing toward human vessel-on-a-chip models
Mechanisms linking pre-mRNA splicing to longevity in C. elegans
Improved methods for age, frailty, and mortality prediction in large-scale longevity studies
Intermittent Fasting (IF) Promotes Longevity through Alterations of the Mammalian Target of Rapamycin (mTOR) and the Epi
Biomarkers of aging for the identification and evaluation of longevity interventions
MIT Open Access Articles NAD+ and sirtuins in aging and disease
Peroxiredoxins in Redox Signaling and Aging
[Regression of survivability variance upon cohort age in Drosophila melanogaster. II: Effects of geroprotective influenc
Sex dimorphic effects in calorie restriction and CR mimetics on longevity
The role of RNA splicing factors in the regulation of longevity
The PETase Tournament and Targeting Aging to Treat Disease
Biopolitics Meets Biosemiotics: The Semiotic Thresholds of Anti-Aging Interventions
The use of DNA methylation clock in aging research.
An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo.
Role of circulating molecules in age-related cardiovascular and metabolic disorders.
Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction.
Worldwide research on calorie restriction in aging. A bibliometric study
Translational Geroscience: From invertebrate models to companion animal and human interventions.
Perspectives of the potential implications of polyphenols in influencing the interrelationship between oxi-inflammatory
Exploring the potential of epigenetic clocks in aging research.
The multiomics blueprint of the individual with the most extreme lifespan.
Drosophila melanogaster as a model system in the study of pharmacological interventions in aging
Chemical Strategies for the Detection and Elimination of Senescent Cells.
The costs and benefits of senotherapeutics for human health.
Biological ageing with HIV infection: evaluating the geroscience hypothesis.
Ganoderma lucidum-Derived Nanovesicles Attenuate Multiorgan Senescence via Modulation of Oxidative Stress and Inflammati
A Targeting Senescence and Recycling Intracellular Nicotinamide Adenine Dinucleotide Strategy for Attenuation of Senesce
Age and life expectancy clocks based on machine learning analysis of mouse frailty
Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle
Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical Translation.
Preserving and rejuvenating old organs for transplantation: novel treatments including the potential of senolytics.
Longevity interventions in Titan mice attenuate frailty and senescence accumulation
Increased alcohol dehydrogenase 1 activity promotes longevity.
Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential
Senolytics, dasatanib plus quercetin, reduce kidney inflammation, senescent cell abundance, and injury while restoring g
Fisetin is a senotherapeutic that extends health and lifespan
Aging in chronic lung disease: Will anti-aging therapy be the key to the cure?
Investigating the bidirectional interactions between senotherapeutic agents and human gut microbiota.
Healthy aging: A bibliometric analysis of the literature.
Nutritional limitation in early postnatal life and its effect on aging and longevity in rodents.
Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal mu
Senescent cell-derived extracellular vesicles as potential mediators of innate immunosenescence and inflammaging.
Metformin turns 62 in pharmacotherapy: Emergence of non-glycaemic effects and potential novel therapeutic applications.
Senolytics and the compression of late-life mortality.
The effect of short-term methionine restriction on glutathione synthetic capacity and antioxidant responses at the whole
Regular exercise effectively protects against the aging-associated decline in skeletal muscle NAD content.
Mild calorie restriction, but not 17α-estradiol, extends ovarian reserve and fertility in female mice.
Repurposing approved drugs as geroprotectors: Experimental versus epidemiological evidence
Targeting pro-senescence mitogen activated protein kinase (Mapk) enzymes with bioactive natural compounds.
P21/P16 Senescence Heterogeneity In Diabetic Bone
Oxidative phosphorylation and fatty acid oxidation in slow-aging mice.
Potential senotherapeutic candidates and their combinations derived from transcriptional connectivity and network measur
Longevity interventions temporally scale healthspan in Caenorhabditis elegans.
Rejuvenation of young blood on aging organs: Effects, circulating factors, and mechanisms.
Tolerance to NADH/NAD+ imbalance anticipates aging and anti-aging interventions.
HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice.
Extracellular vesicle as therapeutic agents in anti-aging: Mechanistic insights and future potential.
Links Between Autophagy and Healthy Aging.
Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions.
Is metformin a geroprotector? A peek into the current clinical and experimental data
Interventions for age-related diseases: Shifting the paradigm.
Geroprotectors: A role in the treatment of frailty.
Anti-aging interventions in geriatric mice: insights into the timing of treatment, benefits, and limitations.
Titan mice as a model to test interventions that attenuate frailty and increase longevity.
Downregulation of the NF-κB protein p65 is a shared phenotype among most anti-aging interventions.
Epigenetic age deceleration reflects exercise-induced cardiorespiratory fitness improvements.
New Directions in Research on Aging.
The Ethics of Anti-aging Clinical Trials.
NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Heal
Journal of Nutrition, Health & Aging: Summary of Recent Work and Future Directions
Dietary restriction in the epigenomic regulation of cardiovascular diseases
Mitochondrial biogenesis and mitophagy
Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction.
Protein kinase modulation for anti-aging intervention
Understanding the relationship between oxidative stress and cognition in the elderly
Senotherapeutics: Milestones, innovations, and future prospects.
Pharmacological frontiers in senescence: Transforming senescence with drug repurposing.
A navitoclax-loaded nanodevice targeting matrix metalloproteinase-3 for the selective elimination of senescent cells.
Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence.
The road ahead for health and lifespan interventions.
Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity.
Compound combinations targeting longevity: Challenges and perspectives.
Discovering geroprotectors through the explainable artificial intelligence-based platform AgeXtend.
CHAPTER 4:Testing of Geroprotectors in Experiments on Cell Cultures: Pros and Cons
Fasting mimicking diet extends lifespan and improves intestinal and cognitive health.
Biomarkers for aging in Caenorhabditis elegans high throughput screening.
Hsp90 inhibitors as senolytic drugs to extend healthy aging
Candidate molecular targets uncovered in mouse lifespan extension studies.
Autophagy promotes visceral aging in wild-type C. elegans.
The ongoing challenge of slowing ageing through drug discovery.
Intermittent time-restricted feeding promotes longevity through circadian autophagy.
Novel strategies for anti-aging drug discovery.
Effects of anti-aging interventions on intestinal microbiota.
Model organism life extending therapeutics modulate diverse nodes in the drug-gene-microbe tripartite human longevity in
Is anti-ageing drug discovery becoming a reality?
From population science to the clinic? Limits of epigenetic clocks as personal biomarkers.
A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer.
Evaluation of the pharmacokinetics of metformin and acarbose in the common marmoset.
Gut microbiota mediates the inhibition of lymphopoiesis in dietary-restricted mice by suppressing glycolysis
Polyphenols as Potential Geroprotectors.
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions
The emerging role of geropathology in preclinical aging studies
β-Nicotinamide Monucleotide Supplement with Astaxanthin and Blood Orange Enhanced NAD+ Bioavailability and Mitigated Age
Unraveling the links between cancer and aging.
New Horizons in cellular senescence for clinicians.
Anti-senescence therapies: a new concept to address cardiovascular disease.
Anti-ageing interventions for the treatment of cardiovascular disease.
Yeast as a tool to identify anti-aging compounds
DNA methylation as a biomarker for cardiometabolic disease risk
Redox-based Disruption of Cellular Hormesis and Promotion of Degenerative Pathways: Perspectives on Aging Processes.
Dynamical Network Stability Analysis of Multiple Biological Ages Provides a Framework for Understanding the Aging Proces
Metformin protects against inflammation, oxidative stress to delay poly I:C-induced aging-like phenomena in gut of an an
Prediction of biological age and evaluation of genome-wide dynamic methylomic changes throughout human aging
Metabolic Regulation of Longevity by Flavin-containing Monooxygenase 2
Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging
Cellular senescence: the good, the bad and the unknown.
Human plasma-derived eNAMPT-containing extracellular vesicles promote NAD+ biosynthesis and thermogenesis in mice
Translating cellular senescence research into clinical practice for metabolic disease.
Cellular senescence and senolytics: the path to the clinic.
A toolbox for the longitudinal assessment of healthspan in aging mice.
The relationship between epigenetic age and the hallmarks of aging in human cells
A senolytic strategy integrating multiple technologies delays aging.
Targeting the biology of aging with mTOR inhibitors
Nature of epigenetic aging from a single-cell perspective.
Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity.
Modelling physical resilience in ageing mice.
Effect of senolytic drugs in young female mice chemically induced to estropause.
C. elegans screening strategies to identify pro-longevity interventions.
The use of geroprotectors to prevent multimorbidity: Opportunities and challenges.
Gender-specific effects of pro-longevity interventions in Drosophila.
Current senolytics: Mode of action, efficacy and limitations, and their future.
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical prac
Liver aging: underlying mechanisms and therapeutic strategies.
Recent advances in the discovery of senolytics.
In the land of not-unhappiness: On the state-of-the-art of targeting aging and age-related diseases by biomedical resear
Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions.
Rodent diet aids and the fallacy of caloric restriction.
Chronic inflammation and the hallmarks of aging.
Targeting cellular senescence in metabolic disease.
Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice.
The role of DNA methylation in epigenetics of aging.
Advances in mass spectrometry-based multi-scale metabolomic methodologies and their applications in biological and clini
Senolytics prevent age-associated changes in female mice brain.
A Senescence-Centric View of Aging: Implications for Longevity and Disease.
Effects of melatonin on a d-galactose-induced male reproductive aging mouse model.
Using light to drive energy transduction in metazoan aging.
Geroneuroprotectors: Effective Geroprotectors for the Brain.
Targeting aging mechanisms: pharmacological perspectives.
Faculty Opinions recommendation of Promoting health and longevity through diet: from model organisms to humans.
Faculty Opinions recommendation of Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not
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BIOLOGICAL AGE: METHODOLOGY FOR DETERMINING
Data supplement for Fig 2.
Data supplement for Fig 1.
Supplementary material.
Data supplement for S4, S5, and S6 Figs.
Data supplement for Fig 4.
Data supplement for Western Blot Full Gel Images.
Data supplement for Fig 3.
Data supplement for S2 and S3 Figs.
Data supplement for S1 Fig.
A simplified design for the C. elegans lifespan machine.
Effects of Rhodiola rosea and aspirin on behaviour and some biochemical parameters in old mice
Spermidine protects cellular redox status and ionic homeostasis in D-galactose induced senescence and natural aging rat
Az élettartamot meghatározó exogén és endogén tényezők • Exogenous and Endogenous Factors Determining Lifespan
Relating aging and autophagy: a new perspective towards the welfare of human health.
Exploring the role of mTOR pathway in aging and age-related disorders.
Kidney Disease as a Driver of Immunosenescence: Mechanisms and Potential Interventions.
Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways
eLife Assessment: Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved
Regulation of Stress-Induced Longevity
Author response: Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved l
Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice
Author response: Epigenetic age-predictor for mice based on three CpG sites
A scalable and tunable platform for functional interrogation of peptide hormones in fish.
eLife assessment: Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation
AGE REVERSAL BY TRANSCRIPTOMIC REPROGRAMMING
Anti-aging Interventions: Caloric Restriction and Beyond
Ancient metabolic switches underpinning organismal longevity
[Attitudes toward aging prevention: results of a focus groups study].
The impact of short-lived controls on the interpretation of lifespan experiments and progress in geroscience - Through t
Uncertainty quantification in epigenetic clocks via conformalized quantile regression.
Molecular signatures of longevity identify compounds that extend mouse lifespan and healthspan
A Pan-Tissue Epigenetic Aging Clock Across the Human Lifespan: Robust Age Prediction from DNA Methylation Profiles
Age‐specific mortality and fecundity of a spider mite under diet restriction and delayed mating
Sex differences in lifespan extension with acarbose and 17‐α estradiol: gonadal hormones underlie male‐specific improvem
Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD<sup>+</sup> redox
Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent c
Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic.
Functional microbiome deficits associated with ageing: Chronological age threshold
Mitochondrial‐targeted catalase is good for the old mouse proteome, but not for the young: ‘reverse’ antagonistic pleiot
Overexpression of CYB 5R3 and NQO 1, two NAD <sup>+</sup>‐producing enzymes, mimics aspects of caloric restriction
The effect of a pharmaceutical ghrelin agonist on lifespan in C57BL / 6J male mice: A controlled experiment
Endocrine Regulation of Aging in the Fruit Fly Drosophila melanogaster
PICLS with human cells - first high-throughput screening method with human assay identifies novel longevity compounds in
In vivo medical imaging for assessing geroprotective interventions in humans
Regulators of health and lifespan extension in genetically diverse mice on dietary restriction
Longevity Interventions Temporally Scale Healthspan in <i>Caenorhabditis elegans</i>
An epigenetic clock for chronological age estimation in East Asian populations
Bioactive Anti-Aging Substances: Geroprotectors
Cellular Senescence and Senolytic Agents: Recent Updates on Their Role and Applications.
Aging and senotherapeutics
Natural Products as a Major Source of Candidates for Potential Senolytic Compounds obtained by in silico Screening.
DIY Intervention Testing in Daphnia
An Obscure Natural NAD + -Boosting Sirtuin Activator: N 1 -Methylnicotinamide (1-MNA)
Feasibility of an Embedded Voice-Based AI Health Monitoring Within a Group-Based Longevity Program for Older Adults (Pre
Aging delay: of mice and men.
Boosting NAD+ for Anti-Aging: Mechanisms, Interventions, and Opportunities
Artificial intelligence-assisted identification and validation of anti-aging biomarkers
From genoprotection to rejuvenation.
Metformina farmaco anti-aging? Tra promesse ed evidenze
The regeneration model of aging and its practical implications
Slowing aging across all ages: from theory to practice
Slowing aging across all ages: from theory to practice
Influence of Metabolic Interventions on Animal Aging and Lifespan
A Need for Refined Senescence Biomarkers and Measures of Senolytics in the Brain.
The Brain-body Energy Conservation Model of Aging
Aging management — a new strategy for cardiovascular risk prevention
Evaluation of exploratory fluid biomarkers from a phase 1 senolytic trial in mild Alzheimer's disease.
Healthy ageing: the natural consequences of good nutrition-a conference report.
Stress response capacity analysis during aging and possible new insights into aging studies.
Redox signaling and modulation in ageing.
Molecular and Cellular Foundations of Aging of the Brain: Anti-aging Strategies in Alzheimer's Disease.
Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial
Diabetes mellitus correlates with increased biological age as indicated by clinical biomarkers
In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes
Potential geroprotectors - from the banch to the clinic
Targeting the Mitochondria-Proteostasis Axis to Delay Aging.
Geroprotectors and Skeletal Health: Beyond the Headlines.
Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells.
Drugs against metabolic diseases as potential senotherapeutics for aging-related respiratory diseases.
Editorial: Proceedings of the 3rd International Conference on Genetics of Aging and Longevity.
Atorvastatin Therapy Modulates Telomerase Activity in Patients Free of Atherosclerotic Cardiovascular Diseases
Clinical Trials Targeting Aging
The hallmarks of aging as a conceptual framework for health and longevity research
Premature aging in genetic diseases: what conclusions can be drawn for physiological aging
Toward precision longevity: aging interventions in the single-cell atlas era.
Calorie Restriction Modulates Gene Expression of Il19 and Il24 of during Renal Aging.
Validation requirements for AI-based intervention-evaluation in aging and longevity research and practice.
Dynamical Network Stability Analysis of Multiple Biological Ages Provides a Framework for Understanding the Aging Proces
The Anti-Aging Effect of Metformin on C. elegans Through Idha-1, an Isocitrate Dehydrogenase in the TCA Cycle
Zebrafish Aging Models and Possible Interventions
Mild Uncoupling of Mitochondria Synergistically Enhances Senolytic Specificity and Sensitivity of BH3 Mimetics.
Genetic diversity estimates for the Caenorhabditis Intervention Testing Program screening panel.
Targeting neuroinflammation - a potential for anti-aging interventions.
Fish oil supplements, longevity and aging.
It is necessary to establish an International Agency for Research on Aging.
Perspectives of Homo sapiens lifespan extension: focus on external or internal resources?
Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8
Meeting Report: Aging Research and Drug Discovery
Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in ger
Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic.
Senolytic effect of high intensity interval exercise on human skeletal muscle.
Epigenetic drift underlies epigenetic clock signals, but displays distinct responses to lifespan interventions, developm
Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic
Effects of a natural ingredients-based intervention targeting the hallmarks of aging on epigenetic clocks, physical func
Role of growth differentiation factor 11 in development, physiology and disease
Caloric restriction creates a metabolic pattern of chronological aging delay that in budding yeast differs from the meta
Exploring juventology: unlocking the secrets of youthspan and longevity programs
Sirolimus use in allogeneic hematopoietic cell transplant recipients: assessing its senotherapeutic role in a high risk
Geroscience and pathology: a new frontier in understanding age-related diseases.
Therapeutic Antiaging Strategies
Influence of Adipokines on Metabolic Dysfunction and Aging.
New Trends in Aging Drug Discovery
Protection against <i>APOE4</i> -associated aging phenotypes with the longevity-promoting intervention 17α-estradiol in
Assessment of Pullulan, a Microbial Polysaccharide, as a Matrix for Senotherapeutics Delivery
Epigenetic Mechanisms in Hematologic Aging and Premalignant Conditions
Longevity: Lesson from Model Organisms.
Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges an
The sex- and duration-dependent effects of intermittent fasting on lifespan and reproduction of spider mite Tetranychus
Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites
Structure-based machine learning screening identifies natural product candidates as potential geroprotectors.
Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy
Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice
DNA methylation aging and transcriptomic studies in horses
A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice.
Cellular aging in vitro recapitulates multi-tissue epigenetic aging in vivo
Youthful and age-related matreotypes predict drugs promoting longevity.
A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudi
Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice
Cost-effective epigenetic age profiling in shallow methylation sequencing data
Machine-learning-based predictions of caloric restriction associations across ageing-related genes
PRC2 clock: a universal epigenetic biomarker of aging and rejuvenation
Novel feature selection methods for construction of accurate epigenetic clocks.
Epigenetic clocks for mice based on age-associated regions that are conserved between mouse strains and human
Age related disorder in DNA methylation patterns underlies epigenetic clock signals, but displays distinct responses to
Compression of morbidity by interventions that steepen the survival curve.
Testing the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim.
Ndufs4-/- mice: a testing ground for longevity interventions.
Discrimination of normal from slow-aging mice by plasma metabolomic and proteomic features.
Pro-longevity compounds extend Caenorhabditis elegans male lifespan and reproductive healthspan.
The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan.
A new compound that extends the lifespan of worms, with favorable in vitro properties and a lack of toxicity in rodents.
PRC2-AgeIndex as a universal biomarker of aging and rejuvenation.
Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans.
High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend health
Sex-specific insights into drug-induced lifespan extension and weight loss in mice
Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice
Modeling treatment of diabetic wounds with oxygen therapy and senolytic drug.
Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging
Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinat
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALER
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.
Transcriptomic Analysis of the Effect of Torin-2 on the Central Nervous System of Drosophila melanogaster
Exploring Senolytic and Senomorphic Properties of Medicinal Plants for Anti-Aging Therapies.
In Silico Assessment of Potential Geroprotectors: From Separate Endpoints to Complex Pharmacotherapeutic Effects.
Senotherapeutics for Brain Aging Management.
Effects of Parental Dietary Restriction on Offspring Fitness in Drosophila melanogaster
Senolytics and Dietary Phytochemicals: Exploring Anti-Aging Strategies and Mechanisms in Aging and Disease
Determinants of human longevity: input of environment, nutrition, physical activity, eustress, heredity, health care, mo
Cross-species functional modules link proteostasis to human normal aging.
SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2
Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels i
Unexpected Increase in Bone Mineral Density With Rapamycin and Low-Dose Naltrexone: A Case Report of a 52-Year-Old Woman
Current Research On Epigenetic Age and Cellular Senescence: A Bibliometric and Visual Analysis
Organ specificity and commonality of epigenetic aging in low- and high-running capacity rats
DNAm aging biomarkers are responsive: Insights from 51 longevity interventional studies in humans
Pro-longevity compounds extend Caenorhabditis elegans male lifespan and reproductive healthspan.
Reporting quality, effect sizes, and biases for aging interventions: a methodological appraisal of the DrugAge database.
Rapamycin Reverses the Hepatic Response to Diet‐Induced Metabolic Stress That Is Amplified by Aging
scAgeClock: a single-cell transcriptome based human aging clock model using gated multi-head attention neural networks
Cross-species functional modules link proteostasis to human normal aging.
Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in <i>C. elegans
Immune Memory in Aging: a Wide Perspective Covering Microbiota, Brain, Metabolism, and Epigenetics.
Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omics.
Universal DNA methylation age across mammalian tissues
TIME-Seq Enables Scalable and Inexpensive Epigenetic Age Predictions
The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent
Reduced insulin signalling in neurons induces sex-specific health benefits
Longevity and rejuvenation effects of cell reprogramming are decoupled from loss of somatic identity
Multidimensional proteomics identifies molecular trajectories of cellular aging and rejuvenation
A combination of the geroprotectors trametinib and rapamycin is more effective than either drug alone
Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting
Caloric restriction induced epigenetic effects on aging
Genetic Pathways of Aging and Their Relevance in the Dog as a Natural Model of Human Aging
Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models.
Mechanistic Links Between the Gut Microbiome and Longevity Therapeutics
The Effect of Calorie Restriction and Intermittent Fasting on Health and Disease
Turning Back the Clock: A Retrospective Single-Blind Study on Brain Age Change in Response to Nutraceuticals Supplementa
Senescent Cells: A Therapeutic Target in Cardiovascular Diseases.
The Integration Breakthrough: Sequenced Rapamycin, Senolytics, and NAD+ Boosters for Enhanced Anti-Aging Based on Cellul
Geroprotectors as a therapeutic strategy for COPD - where are we now?
The Role and Application of the AMPK-Sirtuins Network in Cellular Senescence.
In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy s
Janssens, Georges E; Houtkooper
g.e.janssens@amsterdamumc.nl
Identification of longevity compounds with minimized probabilities of side effects.
ViewXinyi; Barzilai, David; Thor
d.barzilai@gcls.study
Bridging expectations and science: a roadmap for the future of longevity interventions.
ViewAnna J.; Mattison, Julie A.; Salmon
Julie.mattison@nih.gov
Alfatah, Mohammad; Eisenhaber
alfatahm@bii.a-star.edu.sg
The PICLS high-throughput screening method for agents extending cellular longevity identifies 2,5-anhydro-D-mannitol as
ViewHorvath, Steve; Singh
shorvath@mednet.ucla.edu
Reversal of biological age in multiple rat organs by young porcine plasma fraction
ViewEpigenetic clock and DNA methylation analysis of porcine models of aging and obesity.
ViewM. B. Birkisdóttir; Lisanne J. van’t Sant; R. Brandt; S. Barnhoorn; J. Hoeijmakers; W. Vermeij; D. Jaarsma
D.Jaarsma@erasmusmc.nl
Purkinje-cell-specific DNA repair-deficient mice reveal that dietary restriction protects neurons by cell-intrinsic pres
ViewMikhail; Moskalev, Alexey
amoskalev@list.ru
Geroprotective and Radioprotective Activity of Quercetin, (-)-Epicatechin, and Ibuprofen in Drosophila melanogaster.
ViewThe Evaluation of Geroprotective Effects of Selected Flavonoids in Drosophila melanogaster and Caenorhabditis elegans.
ViewEffects of N-acetyl-L-cysteine on lifespan, locomotor activity and stress-resistance of 3 Drosophila species with differ
ViewEwald, Collin Y
collin-ewald@ethz.ch
Drug Screening Implicates Chondroitin Sulfate as a Potential Longevity Pill.
ViewMartijn E T; Vermeij, Wilbert P
W.P.Vermeij@prinsesmaximacentrum.nl
The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotina
ViewBlagosklonny, Mikhail V
Blagosklonny@oncotarget.com
Max; Lithgow, Gordon J; Driscoll
glithgow@buckinstitute.org
The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound interven
ViewBjedov, Ivana; Rallis
i.bjedov@ucl.ac.uk
Siming; Gladyshev, Vadim N
vgladyshev@rics.bwh.harvard.edu
Gene expression signatures of human cell and tissue longevity.
ViewDaniele; Ehninger, Dan
Dan.Ehninger@dzne.de
Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?
ViewEvery-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice
ViewDeep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/
ViewGordon J.; Driscoll, Monica; Phillips
driscoll@dls.rutgers.edu
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity ef
ViewOliver; Kroemer, Guido
kroemer@orange.fr
Isobacachalcone induces autophagy and improves the outcome of immunogenic chemotherapy
ViewHillary A. Miller; Shijiao Huang; Elizabeth S. Dean; Megan L. Schaller; Angela M Tuckowski; Allyson S. Munneke; S. Beydoun; S. Pletcher; S. Leiser
leiser@umich.edu
Serotonin and dopamine modulate aging in response to food odor and availability
ViewK. Avchaciov; M. Antoch; E. L. Andrianova; A. Tarkhov; L. I. Menshikov; O. Burmistrova; A. Gudkov; P. Fedichev
peter.fedichev@gero.ai
Unsupervised learning of aging principles from longitudinal data
ViewHartmut; Wagner, Wolfgang
wwagner@ukaachen.de
E. Platonova; N. Zemskaya; M. Shaposhnikov; D. Golubev; Daria V. Kukuman; N. Pakshina; N. Ulyasheva; V. Punegov; S. Patov; A. Moskalev
amoskalev@ib.komisc.ru
Geroprotective effects of Aronia melanocarpa fruit extract on Drosophila melanogaster
ViewZeynep H; Aguzzi, Adriano
adriano.aguzzi@usz.ch
Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions.
ViewLamming, Dudley W.
dlamming@medicine.wisc.edu
piotr.chmielewski@umed.wroc.pl
Human ageing as a dynamic, emergent and malleable process: from disease-oriented to health-oriented approaches
mvinicki@genos.hr
Regular moderate physical exercise decreases Glycan Age index of biological age and reduces inflammatory potential of Im
arlan-richardson@ouhsc.edu
Effect of rapamycin on aging and age-related diseases—past and future
steven.cummings@ucsf.edu
Endpoints for geroscience clinical trials: health outcomes, biomarkers, and biologic age
peter.fedichev@gero.com
Hacking Aging: A Strategy to Use Big Data From Medical Studies to Extend Human Life.
hahmkb@medpacto.com
Nicotinamide Riboside Vitamin B3 Mitigated C26 Adenocarcinoma–Induced Cancer Cachexia
wuxin@tib.cas.cn
The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Ph
fuchs.beate@fbn-dummerstorf.de
Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals
hjhan@snu.ac.kr
Anti-aging strategies for dogs: current insights and future directions
wongpf@um.edu.my
Anti-senescence effects of 4-methoxychalcone and 4-bromo-4'-methoxychalcone on human endothelial cells.
iflores@cnic.es
Fasting for stem cell rejuvenation
bakula@sund.ku.dk
Latest advances in aging research and drug discovery
fydai@swu.edu.cn
Metformin prolongs lifespan through remodeling the energy distribution strategy in silkworm, Bombyx mori
abartke@siumed.edu
Anti-aging interventions affect lifespan variability in sex, strain, diet and drug dependent fashion.
dkepchia@salk.edu
Geroprotective effects of Alzheimer's disease drug candidates.
gjbrewer@uci.edu
When aging switches on Alzheimer’s
jun.ding@nih.gov
Predicting physiological aging rates from a range of quantitative traits using machine learning
vladimir.titorenko@concordia.ca
Caloric restriction causes a distinct reorganization of the lipidome in quiescent and non-quiescent cells of budding yea
payel.sen@nih.gov
Epigenetic dysregulation in cardiovascular aging and disease.
weijing19841111@163.com
Gut microbiota: an ideal biomarker and intervention strategy for aging.
nschork@tgen.org.
Does Modulation of an Epigenetic Clock Define a Geroprotector?
Volker.burst@uk-koeln.de
Modulation of Endocannabinoids by Caloric Restriction is Conserved in Mice but is not Required for the Protection from A
broshr@mail.nih.gov
Editorial: DNA repair and interventions in aging
qc.zhuge@wmu.edu.cn
Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging
a.kashapov@uaeu.ac.ae
Reappraisal of the Concept of Accelerated Aging in Neurodegeneration and Beyond
oubaha.malika@uqam.ca
Senescent Cells: Dual Implications on the Retinal Vascular System
l.bramwell2@exeter.ac.uk
Repurposing Drugs for Senotherapeutic Effect: Potential Senomorphic Effects of Female Synthetic Hormones.
hklepacki1@student.umb.edu.pl
Molecular Regulation of SASP in Cellular Senescence: Therapeutic Implications and Translational Challenges.
asakawa@m2.kufm.kagoshima-u.ac.jp
The Role of Ghrelin and Ghrelin Signaling in Aging
carlo.gaetano@icsmaugeri.it
Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases.
johanna.hoyer-allo@uk-koeln.de
Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute
nozaki@rs.tus.ac.jp
Contribution of PGC-1α to Obesity- and Caloric Restriction-Related Physiological Changes in White Adipose Tissue
mariagiuli.bacalini2@unibo.it
The Impact of Caloric Restriction on the Epigenetic Signatures of Aging
reinald.pamplona@udl.cat
Age-Related Changes in Lipidome of Rat Frontal Cortex and Cerebellum Are Partially Reversed by Methionine Restriction Ap
sara.franceschelli@unich.it
Mitochondrial Aging and Senolytic Natural Products with Protective Potential.
probbins@umn.edu.
Cellular senescence: a key therapeutic target in aging and diseases.
akonopka@medicine.wisc.edu
Geroprotector drugs and exercise: friends or foes on healthy longevity?
kenneth.rockwood@dal.ca
Fifteen years of progress in understanding frailty and health in aging
manlio.vinciguerra@fnusa.cz
Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin.
ttching@nycu.edu.tw
The impacts of different dietary restriction regimens on aging and longevity: from yeast to humans.
liakondratyeva@yandex.ru
The influence of the geroprotective cytokine on the transcriptome of young and senescent mesenchymal stem cells.
omry.koren@biu.ac.il
The aging mouse microbiome has obesogenic characteristics
mo.li@kaust.edu.sa
Attenuation of primate aging via systemic infusion of senescence-resistant mesenchymal progenitor cells.
egkim@chungbuk.ac.kr
Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema.
Transfer of the longevity-associated variant of BPIFB4 gene rejuvenates immune system and vasculature by a reduction of
hjcho.dr@dgist.ac.kr
Nintedanib induces senolytic effect via STAT3 inhibition.
tuopingluo@pku.edu.cn
Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical functio
ghliu@ioz.ac.cn
A β-galactosidase kiss of death for senescent cells
cmartens@udel.edu
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adult
keith.blackwell@joslin.harvard.edu
ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1
chuang@shutcm.edu.cn
Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functio
Nicholas.Tolwinski@yale-nus.edu.sg
TGH: Trans-Generational Hormesis and the Inheritance of Aging Resistance
krug@thp.uni-koeln.de
Superposition of survival curves as a tool for epistasis analysis of longevity interventions
kuo@uchc.edu
ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants
sergey.dmitriev@belozersky.msu.ru
Multi-faceted deregulation of gene expression and protein synthesis with age
xiaochy@ctgu.edu.cn
Observation of the Transport and Removal of Lipofuscin from the Mouse Myocardium using Transmission Electron Microscope
dual@imes.mavt.ethz.ch
Longevity interventions temporally scale healthspan in Caenorhabditis elegans
Age-associated sleep-wake patterns are altered with Prdm13 signaling in the dorsomedial hypothalamus and dietary restric
bberry5@uw.edu
Preservation of Mitochondrial Membrane Potential is Necessary for Lifespan Extension from Dietary Restriction
In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers
tchandra@exseed.ed.ac.uk
Region-Based Epigenetic Clock Design Improves RRBS-Based Age Prediction
mengwang@janelia.hhmi.org
Aging Atlas Reveals Cell-Type-Specific Regulation of Pro-longevity Strategies
nelsonj@uthscsa.edu
The Gehan test identifies life-extending compounds overlooked by the log-rank test in the NIA Interventions Testing Prog
bonnes.sara@mayo.edu
Establishing healthy longevity clinics in publicly funded hospitals
khascup49@siumed.edu
Senolytic intervention improves cognition, metabolism, and adiposity in female APPNL-F/NL-F mice.
ahaghani@altoslabs.com
EnsembleAge: enhancing epigenetic age assessment with a multi-clock framework
juan.moreno@uco.es
Adaptations of mitochondrial, autophagy and nutrient sensing pathways in the liver from long-lived mice overexpressing C
alessandro.blasimme@hest.ethz.ch
The plasticity of ageing and the rediscovery of ground-state prevention.
jean-marc.brondello@inserm.fr
[Senotherapy: Advances and new clinical perspectives].
liu_xingguo@gibh.ac.cn
NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations
wreik@altoslabs.com
scEpiAge: an age predictor highlighting single-cell ageing heterogeneity in mouse blood
jmertens@health.ucsd.edu
Cellular reprogramming as a tool to model human aging in a dish.
uri.alon@weizmann.ac.il
Compression of morbidity by interventions that steepen the survival curve.
r.h.houtkooper@amsterdamumc.nl
Immuno-metabolic stress responses control longevity from mitochondrial translation inhibition in C. elegans
auparish@bhmcny.org
Reporting quality, effect sizes, and biases for aging interventions: a methodological appraisal of the DrugAge database.
mihaela.zavolan@unibas.ch
Calorie restriction and rapamycin distinctly restore non-canonical ORF translation in the muscles of aging mice.
hamilton.oh@mssm.edu
Plasma proteomics links brain and immune system aging with healthspan and longevity.
onisiforou.anna@ucy.ac.cy
Molecular signatures of premature aging in Major Depression and Substance Use Disorders.
elena.zoico@univr.it
Senolytic effects of quercetin in an in vitro model of pre-adipocytes and adipocytes induced senescence.
shapiroj@marshall.edu
The Na/K-ATPase Oxidant Amplification Loop Regulates Aging.
hidetaka-ota@med.akita-u.ac.jp
Dasatinib plus quercetin attenuates some frailty characteristics in SAMP10 mice.
daixiuliang@126.com
The senolytic drug ABT-263 accelerates ovarian aging in older female mice.
peter.joshi@humanity.email
Biological age estimation using circulating blood biomarkers
sebastian.lobentanzer@helmholtz-munich.de
Benchmarking large language models for personalized, biomarker-based health intervention recommendations.
Ashley_Webb@brown.edu
Single-cell analysis of the aging female mouse hypothalamus
t.minamino@juntendo.ac.jp
SGLT2 inhibition eliminates senescent cells and alleviates pathological aging.
jingyuan.ya@nottingham.ac.uk
Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies.
wang8310@umn.edu
Accelerated Aging in Cancer Survivors: Cellular Senescence, Frailty, and Possible Opportunities for Interventions.
a.latini@med.uniroma2.it
The Senolytic Effect of Indole-3-Carbinol (I3C) on Mouse Embryonic (MEF) and Human Fibroblast Cell Lines.
scbondy@uci.edu
The Critical Role of Autophagy and Phagocytosis in the Aging Brain
gary.arendash@neuroem.com
Transcranial Electromagnetic Wave Treatment: A Fountain of Healthy Longevity?
lvjw@ccucm.edu.cn
Dermal Fibroblast Senescence: The Central Hub of Skin Aging—From Intrinsic Dysfunction to Microenvironmental Remodeling
marijn.speeckaert@ugent.be
Rewinding the Clock: Emerging Pharmacological Strategies for Human Anti-Aging Therapy.
ekushevaev@mail.ru
Epigenetic Clock and Circadian Rhythms in Stem Cell Aging and Rejuvenation
lishuhan1@stu.kust.edu.cn
Development and Application of a Senolytic Predictor for Discovery of Novel Senolytic Compounds and Herbs.
Sunil.Panchal@usq.edu.au
Cholesterol versus Inflammation as Cause of Chronic Diseases
kchadaideh@g.harvard.edu
Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice
egiacomello@units.it
The Potential of Calorie Restriction and Calorie Restriction Mimetics in Delaying Aging: Focus on Experimental Models.
xumeihong@bjmu.edu.cn
Targeting Aging and Longevity with Exogenous Nucleotides (TALENTs): Rationale, Design, and Baseline Characteristics from
ama@icmm.ac.cn
Unveiling the Anti-Aging Potential of 3HB: Lifespan Extension and Cellular Senescence Delay.
hongli.wu@unthsc.edu
Cellular Senescence in Health, Disease, and Lens Aging.
alessandra.gambero@puc-campinas.edu.br
Researching New Drug Combinations with Senolytic Activity Using Senescent Human Lung Fibroblasts MRC-5 Cell Line
yangnanku@nankai.edu.cn
Histone modification and anti-aging intervention
David_Sinclair@hms.harvard.edu
Novel feature selection methods for construction of accurate epigenetic clocks.
shaohua.yang@unthsc.edu
Determination of metformin bio-distribution by LC-MS/MS in mice treated with a clinically relevant paradigm
nathalie.sumien@unthsc.edu
Metformin Impairs Spatial Memory and Visual Acuity in Old Male Mice
wuziyun@sjtu.edu.cn.
Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging
calogero.caruso@unipa.it.
Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience.
nir.barzilai@einsteinmed.org.
Geroscience in the Age of COVID-19.
xinghuapan@aliyun.com
An age classification model based on DNA methylation biomarkers of aging inhuman peripheral blood using random forest an
kirmizis@ucy.ac.cy
Loss of Nat4 and its associated histone H4 N‐terminal acetylation mediates calorie restriction‐induced longevity
lilykeane@ucc.ie
Long-term rapamycin treatment suppresses IL-17-producing gamma delta T cells and blunts neuroinflammation in aging
drsushilmiddha@gmail.com
Synergistic pharmacological interventions and lifestyle modifications to decelerate aging: Targeting cellular senescence
Regulators of health and lifespan extension in genetically diverse mice on dietary restriction
gelfondjal@uthscsa.edu.
Deciphering the Timing and Impact of Life-extending Interventions: Temporal Efficacy Profiler Distinguishes Early, Midli
Tissue-specific modulation of NADH consumption as an anti-aging intervention in Drosophila
jcao@rockefeller.edu
Spatiotemporal profiling reveals the impact of caloric restriction on mammalian brain aging.
titov@berkeley.edu
SRS microscopy identifies inhibition of vitellogenesis as a mediator of lifespan extension by caloric restriction in C.
zhidong.tu@mssm.edu.
A novel approach of human geroprotector discovery by targeting the converging subnetworks of aging and age-related disea
r.h.houtkooper@amc.nl
Identification of key pathways and metabolic fingerprints of longevity in C. elegans
nikolay.ninov@tu-dresden.de
Machine learning based classification of cells into chronological stages using single-cell transcriptomics
jpoyatos@cnb.csic.es
Tolerance to NADH/NAD + imbalance anticipates aging and anti-aging interventions
Quantitative translation of dog-to-human aging by conserved remodeling of epigenetic networks
decabora@grc.nia.nih.gov
Metformin: A Hopeful Promise in Aging Research.
cheng_li@pku.edu.cn
A transcriptome-based single-cell biological age model and resource for tissue-specific aging measures
liujikai@mail.scuec.edu.cn
Antiaging agents: safe interventions to slow aging and healthy life span extension
samir.morsli@ki.se
Emerging insights in senescence: pathways from preclinical models to therapeutic innovations
lars.kaderali@uni-greifswald.de
Modeling transcriptomic age using knowledge-primed artificial neural networks.
Andreas.beyer@uni-koeln.de
Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity
collin-ewald@ethz.ch.
Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity.
heming_liu@163.com
Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Se
ilan@hadassah.org.il
Improving the effectiveness of anti-aging modalities by using the constrained disorder principle-based management algori
amit.dey2@nih.gov
Translating Senotherapeutic Interventions into the Clinic with Emerging Proteomic Technologies.
mark.rinnerthaler@plus.ac.at
The Janus-Faced Role of Lipid Droplets in Aging: Insights from the Cellular Perspective.
galow@fbn-dummerstorf.de
How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span
zuo.4@osu.edu
Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments
fong.sheng@singhealth.com.sg
Towards Healthy Longevity: Comprehensive Insights from Molecular Targets and Biomarkers to Biological Clocks.
daria.tchurikova@yandex.ru
Hepatocytes as Model for Investigating Natural Senotherapeutic Compounds and Their Effects on Cell Cycle Dynamics and Ge
sven.bulterijs@ugent.be
Phenotypic Screening in C. elegans as a Tool for the Discovery of New Geroprotective Drugs
alice.kane@dal.ca
Animal models of frailty: current applications in clinical research
angelamariaserena.lezza@uniba.it
Does eating less make you live longer and better? An update on calorie restriction
ccavadas@uc.pt
Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation