Pharma Investment In Primary Human Cell In Vitro M

Hepatitis C. Development of new drugs and clinical trials: Promises and pitfalls. Summary of an AASLD hepatitis single t

Pawlotsky, Jean–Michel; McHutchison, John G.

Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab an

Papadopoulos, Nicholas; Martin, Joel; Ruan, Qin et al.

Endless healing: TGF‐β, SMADs, and fibrosis

Eickelberg, Oliver

Skin Penetration and Cellular Uptake of Amorphous Silica Nanoparticles with Variable Size, Surface Functionalization, an

Rancan, Fiorenza; Gao, Qi; Gräf, Christina et al.

Targeting breast cancer stem cells

Wicha, Max S.

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examin

Henn, Anja

Genome-Wide siRNA-Based Functional Genomics of Pigmentation Identifies Novel Genes and Pathways That Impact Melanogenesi

Ganesan, Anand K.; Ho, Hsiang; Bodemann, Brian O. et al.

Mesenchymal Stem Cell Transition to Tumor-Associated Fibroblasts Contributes to Fibrovascular Network Expansion and Tumo

Spaeth, Erika L.; Dembinski, Jennifer L.; Sasser, A. Kate et al.

Blood-brain barrier active efflux transporters: ATP-binding cassette gene family

Löscher, Wolfgang; Potschka, Heidrun

The Mitogen-Activated Protein Kinase Pathway Mediates Estrogen Neuroprotection after Glutamate Toxicity in Primary Corti

Singer, Cherie A.; Figueroa, Xavier A.; Batchelor, Robert H. et al.

Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery

Alavijeh, Mohammad S.; Chishty, Mansoor; Qaiser, M. Zeeshan et al.

Mechanism of Toxicity in Rotenone Models of Parkinson's Disease

Sherer, Todd; Betarbet, Ranjita; Testa, Claudia et al.

Design and application of microfluidic systems for in vitro pharmacokinetic evaluation of drug candidates.

Maguire, T J; Novik, E; Chao, P et al.

Magnetic nanoparticles for gene and drug delivery

Dobson, Jon

Adaptation of High-Throughput Screening in Drug Discovery—Toxicological Screening Tests

Szymański, Paweł; Markowicz-Piasecka, Magdalena; Mikiciuk‐Olasik, Elżbieta

Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications

Cheung, Randy Chi Fai; Ng, Tzi Bun; Wong, Jack Ho et al.

Alginate-Based Biomaterials for Regenerative Medicine Applications

Sun, Jinchen; Tan, Huaping

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

Fits, Leslie van der; Mourits, Sabine; Voerman, Jane S.A. et al.

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

Dovey, Harry F.; John, Varghese; Anderson, J. P. et al.

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential—towards a consensus

Tucker, Geoffrey T.; Houston, J. Brian; Huang, Shiew‐Mei

Comparative Proteomic Phenotyping of Cell Lines and Primary Cells to Assess Preservation of Cell Type-specific Functions

Pan, Cuiping; Kumar, Chanchal; Böhl, Sebastian et al.

Orphan Nuclear Receptors: The Exotics of Xenobiotics

Xie, Wen; Evans, Ronald M.

A Small Molecule Antagonist of Chemokine Receptors CCR1 and CCR3

Sabroe, Ian; Peck, Michael J.; KEULEN, B. J. VAN et al.

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid

Kast-Woelbern, Heidi R.; Goodwin, Bryan; Tarr, Paul T. et al.

Peptide Immunoaffinity Enrichment and Targeted Mass Spectrometry Enables Multiplex, Quantitative Pharmacodynamic Studies

Whiteaker, Jeffrey R.; Zhao, Lei; Yan, Ping et al.

Screening for Drug-Induced Hepatotoxicity in Primary Mouse Hepatocytes Using Acetaminophen, Amiodarone, and Cyclosporin

Summeren, Anke Van; Renes, Johan; Lizárraga, Daneida et al.

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

Lin, Athena W.; Barradas, Marta; Stone, James C. et al.

HIV infection and the gastrointestinal tract

Kotler, Donald P.

Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology

Leung, Maxwell C. K.; Williams, Phillip L.; Benedetto, Alexandre et al.

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

Xu, Jinghai J.; Henstock, Peter; Dunn, Margaret C. et al.

A novel EST‐derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in β2‐adrenergic receptor inte

Jiang, Xiaofeng; Pan, Hui; Nabhan, Joseph F. et al.

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

Constantinescu, Cris S.; Farooqi, Nasr; O’Brien, Kate et al.

A cell‐based screening assay to identify pharmaceutical compounds that enhance the regenerative quality of corneal repai

Gordon, Gabriel M.; LaGier, Adriana J.; Ponchel, C. et al.

The in vitro Inhibitory Effect of Tannin Derivatives on 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase on Vero Cells

Chang, Jun‐Jen; Chen, Tso-Hsiao; Chan, Paul et al.

Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle c

Sukhova, Galina K.; Shi, Guo‐Ping; Simon, Daniel I. et al.

CEP-28122, a Highly Potent and Selective Orally Active Inhibitor of Anaplastic Lymphoma Kinase with Antitumor Activity i

Cheng, Mangeng; Quail, Matthew R.; Gingrich, Diane E. et al.

Liver fibrosis

Bataller, Ramón; Brenner, David A.

Brown Fat Develops a <i>Brite</i> Future

Klingenspor, Martin; Herzig, Stephan; Pfeifer, Alexander

CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI

Lannutti, Brian J.; Meadows, Sarah; Herman, Sarah E.M. et al.

The relevance and potential roles of microphysiological systems in biology and medicine

Wikswo, John P.

Inhibition of HIF1A Signaling by a Novel Class of Sulfonanilides for Targeted Treatment of Multiple Myeloma.

Hose, Dirk; Seckinger, Anja; Goldschmidt, Hartmut et al.

CAL-101, An Oral p110δ Selective Phosphatidylinositol-3-Kinase (PI3K) Inhibitor for the Treatment of B Cell Malignancies

Lannutti, Brian J.; Meadows, Sarah; Kashishian, Adam et al.

Dual PI3Kδ/γ Inhibition By RP6530 Induces Apoptosis and Cytotoxicity In B-Lymphoma Cells

Vakkalanka, Swaroop; Viswanadha, Srikant; Gaudio, Eugenio et al.

Evidence That Activated Hedgehog Signaling Predicts for Poor Clinical Outcome in Acute Myeloid Leukemia

Campbell, Veronica T.; Tholouli, Eleni; Quigley, Mikayla et al.

Patient-Derived Xenografts (PDX) of B Cell Lymphoma in NSG Mice: A Mouse Avatar for Developing Personalized Medicine

Gerstein, Rachel M.; Zhou, Zheng; Zhang, Hong et al.

Antileukemic Effects of the Novel Agent Elesclomol.

Chow, Sue; Nagai, Masazumi; He, Suqin et al.

ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies

Hinderliter, Paul M.; Minard, Kevin R.; Orr, Galya et al.

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation

Vinci, Maria; Gowan, Sharon; Boxall, Frances et al.

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

Carpenter, Anne E.; Jones, Thouis R.; Lamprecht, Michael R. et al.

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

Mathur, Anurag; Loskill, Peter; Shao, Kaifeng et al.

DOT1L and Histone H3 Lysine79 Methylation as a Therapeutic Target in Mixed Lineage Leukemia.

Bernt, Kathrin M.; Faber, Jörg; Davis, Tina et al.

Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects

Li, Hongyi; Yang, Yang; Hong, Weiqi et al.

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Cao, Huấn; Duan, Lixia; Zhang, Yan et al.

Embryonic stem cell differentiation: emergence of a new era in biology and medicine

Keller, Gordon

Intestinal permeability – a new target for disease prevention and therapy

Bischoff, Stephan C.; Barbara, Giovanni; Buurman, Wim A. et al.

A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

Reddy, M. Sai Bhargava; Ponnamma, Deepalekshmi; Choudhary, Rajan et al.

Is It Time to Start Transitioning From 2D to 3D Cell Culture?

Jensen, Caleb; Teng, Yong

Overview of General and Discriminating Markers of Differential Microglia Phenotypes

Jurga, Agnieszka M.; Paleczna, Martyna; Kuter, Katarzyna

Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration

Tottoli, Erika Maria; Dorati, Rossella; Genta, Ida et al.

Three-Dimensional Cell Culture Matrices: State of the Art

Lee, Jungwoo; Cuddihy, Meghan; Kotov, Nicholas A.

The Hippo pathway: regulators and regulations

Yu, Fa‐Xing; Guan, Kun‐Liang

Polymeric Scaffolds in Tissue Engineering Application: A Review

Dhandayuthapani, Brahatheeswaran; Yoshida, Yasuhiko; Maekawa, Toru et al.

Bone regeneration: current concepts and future directions

Dimitriou, Rozalia; Jones, Elena; McGonagle, Dennis et al.

The hCMEC/D3 cell line as a model of the human blood brain barrier

Weksler, Babette B.; Romero, Ignacio A.; Couraud, Pierre‐Olivier

Pathophysiology, treatment, and animal and cellular models of human ischemic stroke

Woodruff, Trent M.; Thundyil, John; Tang, Sung‐Chun et al.

Lost in translation: the valley of death across preclinical and clinical divide – identification of problems and overcom

Seyhan, Attila A.

Tumor microenvironment complexity and therapeutic implications at a glance

Baghban, Roghayyeh; Roshangar, Leila; Jahanban‐Esfahlan, Rana et al.

Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D b

Abasalizadeh, Farhad; Moghaddam, Sevil Vaghefi; Alizadeh, Effat et al.