Fed Batch Feeding Strategies For Cho Cell Cultures

Towards in situ continuous feeding via controlled release of complete nutrients for fed-batch culture of animal cells

A Multi Clone Kinetic Model for characterizing Chinese hamster ovary cell line variability

Optimal design of dynamic experiments for scalar-on-function linear models with application to a biopharmaceutical study

Comparing Kinetic versus Stoichiometric Priorities in Hybrid Models of CHO Metabolism

Development of Raman Calibration Model Without Culture Data for In-Line Analysis of Metabolites in Cell Culture Media

FACTORS AFFECTING CHINESE HAMSTER OVARY CELL PROLIFERATION AND VIABILITY

Using MVDA with Stoichiometric Balances to Optimize Amino Acid Concentrations in Chemically Defined CHO Cell Culture Med

Estimating Extrinsic Dyes for Fluorometric Online Monitoring of Antibody Aggregation in CHO Fed-Batch Cultivations

Deciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computa

Continuous Feeding Reduces the Generation of Metabolic Byproducts and Increases Antibodies Expression in Chinese Hamster

A Metabolomics Approach to Increasing Chinese Hamster Ovary (CHO) Cell Productivity

Scaling Fed-Batch and Perfusion Antibody Production Processes in Geometrically Dissimilar Stirred Bioreactors

3D Printed, Single-Use Bioreactor with Integrated Inline Sensors for Microbial and Mammalian Cell Cultivation—A Case Stu

Towards Autonomous Process Control—Digital Twin for CHO Cell-Based Antibody Manufacturing Using a Dynamic Metabolic Mode

Accelerating Biologics Manufacturing by Upstream Process Modelling

Accelerating Biomanufacturing by Modeling of Continuous Bioprocessing—Piloting Case Study of Monoclonal Antibody Manufac

Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors

Dielectric Spectroscopy and Optical Density Measurement for the Online Monitoring and Control of Recombinant Protein Pro

Intensified Influenza Virus Production in Suspension HEK293SF Cell Cultures Operated in Fed-Batch or Perfusion with Cont

NOISE AWARE BAYESIAN PARAMETER ESTIMATION IN BIOPROCESSES

Equal mixing time enables scale-down and optimization of a CHO cell culture process using a shaken microbioreactor syste

Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data‐driven and model‐guided anal

On‐Line Control of Glucose Concentration in High‐Yielding Mammalian Cell Cultures Enabled Through Oxygen Transfer Rate M

Continuous optical in‐line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency w

Noise aware parameter estimation in bioprocesses: Using neural network surrogate models with nonuniform data sampling

Process intensification to produce a difficult‐to‐express therapeutic enzyme by high cell density perfusion or enhanced

Segmented linear modeling of CHO fed‐batch culture and its application to large scale production

Raman‐controlled pyruvate feeding to control metabolic activity and product quality in continuous biomanufacturing

“Organized stress” for robust scale‐up of intensified production process with fed‐batch seed bioreactor

Application of metabolic modeling for targeted optimization of high seeding density processes

Real‐time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture usi

Biomass specific perfusion rate as a control lever for the continuous manufacturing of biosimilar monoclonal antibodies

Comparison of mechanistic and hybrid modeling approaches for characterization of a CHO cultivation process: Requirements

Novel Data‐Driven Mechanistic Modeling of Untargeted Metabolome Data Reveals Feed Component Effects in CHO Cell Bioproce

Process‐induced cell cycle oscillations in CHO cultures: Online monitoring and model‐based investigation

Media on‐demand: Continuous reconstitution of a chemically defined media directly from solids

Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided

A compendium of stable hotspots in the CHO genome

Cell culture product quality attribute prediction using convolutional neural networks and Raman spectroscopy

Soft‐sensors application for automated feeding control in high‐throughput mammalian cell cultures

Temporal Galactose‐Manganese Feeding in Fed‐Batch and Perfusion Bioreactors Modulates UDP‐Galactose Pools for Enhanced m

Machine learning‐based model predictive controller design for cell culture processes

Mimicking CHO large‐scale effects in the single multicompartment bioreactor: A new approach to access scale‐up behavior

A system identification approach for developing model predictive controllers of antibody quality attributes in cell cult

Developing an ultra‐intensified fed‐batch cell culture process with greatly improved performance and productivity

Tuning monoclonal antibody galactosylation using Raman spectroscopy‐controlled lactic acid feeding

Quick generation of Raman spectroscopy based in-process glucose control to influence biopharmaceutical protein product q

Physics‐informed neural networks for biopharmaceutical cultivation processes: Consideration of varying process parameter

CHO stable pool fed-batch process development of SARS-CoV-2 spike protein production: Impact of aeration conditions and

Neural ordinary differential equation‐based model predictive controller for regulating glucose concentration in a fed‐ba

Process development for an inducible rituximab‐expressing Chinese hamster ovary cell line

Real‐time quantification and supplementation of bioreactor amino acids to prolong culture time and maintain antibody pro

A recurrent neural network for soft sensor development using CHO stable pools in fed‐batch process for SARS ‐ CoV ‐2 spi

Raman-based dynamic feeding strategies using real-time glucose concentration monitoring system during adalimumab produci

A protocol to transfer a fed‐batch platform process into semi‐perfusion mode: The benefit of automated small‐scale biore

An assessment of the impact of Raman based glucose feedback control on CHO cell bioreactor process development

A statistical approach to improve compound screening in cell culture media

Elevated pCO 2 affects the lactate metabolic shift in CHO cell culture processes

N‐1 semi‐continuous transient perfusion in shake flask for ultra‐high density seeding of CHO cell cultures in benchtop b

Rapid total sialic acid monitoring during cell culture process using a machine learning model based soft sensor

Automized inline monitoring in perfused mammalian cell culture by MIR spectroscopy without calibration model building

Dynamic pH profiles drive higher cell‐specific and volumetric productivity

Stress‐induced increase of monoclonal antibody production in CHO cells

Performance benchmark of different cell clones in discontinuous and continuous bioprocesses reveals critical impact of c

Maduramycin, a novel glycosylation modulator for mammalian fed-batch and steady-state perfusion processes

Towards the Development of Automated Fed-Batch Cell Culture Processes at Microscale