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Investigating the combination of single‐pass tangential flow filtration and anion exchange chromatography for intensifie
Enhancing Protein A performance in mAb processing: A method to reduce and rapidly evaluate host cell DNA levels during p
The effect of feed quality due to clarification strategy on the design and performance of protein A periodic counter-cur
Effectiveness of host cell protein removal using depth filtration with a filter containing diatomaceous earth.
Anxa2- and Ctsd-knockout CHO cell lines to diminish the risk of contamination with host cell proteins.
An innovative strategy to recycle permeate in biologics continuous manufacturing process to improve material efficiency
Identification of upstream culture conditions and harvest time parameters that affect host cell protein clearance.
Development of an activated carbon filtration step and high throughput screening method to remove host cell proteins fro
Toward optimal clearance: A universal affinity-based mass spectrometry approach for comprehensive ELISA reagent coverage
Identification and characterization of a residual host cell protein hexosaminidase B associated with N-glycan degradatio
Host cell proteins in monoclonal antibody processing: Control, detection, and removal.
Depth filter material process interaction in the harvest of mammalian cells
Proteomic analysis of host cell protein fouling during bioreactor harvesting.
Proteomics‐based method to comprehensively model the removal of host cell protein impurities
Design and optimization of membrane chromatography for monoclonal antibody charge variant separation.
Methods comparison of two-dimensional gel electrophoresis for host cell protein characterization.
Use of LC-MS to characterize host cell protein removal during depth filtration.
Establishment and evaluation of detection methods for process-specific residual host cell protein and residual host cell
In silico mediated development of orthogonally selective mAb downstream processes for the removal of process-related imp
Analytical characterization of host-cell-protein-rich aggregates in monoclonal antibody solutions.
A novel approach for protein identification from complex cell proteome using modified peptide mass fingerprinting algori
Harnessing the power of electrophoresis and chromatography: Offline coupling of reverse phase liquid chromatography-capi
Risk control of host cell proteins in one therapeutic antibody produced by concentrated fed-batch (CFB) mode.
Comprehensive analysis of host cell impurities in monoclonal antibodies with improved sensitivity by capillary zone elec
Improving Downstream Process Related Manufacturability Based on Protein Engineering-A Feasibility Study.
Optimizing selectivity of anion hydrophobic multimodal chromatography for purification of a single-chain variable fragme
Aqueous Two-Phase-Assisted Precipitation of Proteins: A Platform for Isolation of Process-Related Impurities from Therap
Development of Peptide Ligands for Targeted Capture of Host Cell Proteins from Cell Culture Production Harvests.
Advanced mass spectrometry workflows for accurate quantification of trace-level host cell proteins in drug products: Ben
An innovative standard for LC-MS-based HCP profiling and accurate quantity assessment: Application to batch consistency
Removal of Residual DNA and Host Cell Proteins for the Purification of Recombinant Staphylokinase Expressed in <i>Escher
Sample Preparation of Secreted Mammalian Host Cell Proteins and Their Characterization by Two-Dimensional Electrophoresi
Characterization of Host Cell Proteins (HCPs) in CHO Cell Bioprocesses.
Purification of Therapeutic Antibodies by Protein A Affinity Chromatography.
Analytical Tools for HCP Detection, Identification, and Quantitation.
Detection of Residual Host Cell Proteins in Biotherapeutic Drugs by Concatenated 2D LC-MS/MS.
Studying host cell protein based on 2D nano-LC-MS/MS: comparison between the removal and the reservation of the main ant
Analysis of Host Cell Proteins in Monoclonal Antibody Therapeutics Through Size Exclusion Chromatography.
Measuring Lipolytic Activity to Support Process Improvements to Manage Lipase-Mediated Polysorbate Degradation.
Ultrasensitive method for profiling host cell proteins by coupling limited digestion to ProteoMiner technology.
Development of a multiplexing method for the quantification of "high-risk" host cell lipases in biotherapeutic
Universal protocol and standard-spiking strategy for profiling of host cell proteins in therapeutic growth hormone.
Improved host cell protein analysis in monoclonal antibody products through ProteoMiner.
Comprehensive host cell proteins profiling in biopharmaceuticals by a sensitivity enhanced mass spectrometry strategy us
Host cell protein testing strategy for hepatitis B antigen in Hexavalent vaccine - Towards a general testing strategy fo
A highly sensitive and robust LC-MS platform for host cell protein characterization in biotherapeutics.
Characterization of host cell proteins in the downstream process of plant-Based biologics using LC-MS profiling.
Hydrophobic interaction chromatography as polishing step enables obtaining ultra-pure recombinant antibodies.
Characterization of membrane adsorbers used for impurity removal during the continuous purification of monoclonal antibo
A two-step heat treatment of cell disruption supernatant enables efficient removal of host cell proteins before chromato
Residual on column host cell protein analysis during lifetime studies of protein A chromatography.
Evaluation of chromatofocusing as a capture method for monoclonal antibody products.
Continuous precipitation of process related impurities from clarified cell culture supernatant using a novel coiled flow
Polyclonal antibodies for specific detection of tobacco host cell proteins can be efficiently generated following RuBisC
Characterization of Residual Host Cell Protein Impurities in Biotherapeutics
Bioinformatic analysis of Chinese hamster ovary host cell protein lipases.
A combined pH and temperature precipitation step facilitates the purification of tobacco-derived recombinant proteins th
Quantitative definition and monitoring of the host cell protein proteome using iTRAQ - a study of an industrial mAb prod
An ultra scale-down approach identifies host cell protein differences across a panel of mAb producing CHO cell line vari
Toward improved host cell protein impurity assessment
Integrated Chromatographic Platform for Simultaneous Separation of Charge Variants and Aggregates from Monoclonal Antibo
Proteomics Reveals Distinctive Host Cell Protein Expression Patterns in Fed-Batch and Perfusion Cell Culture Processes.
Immunoglobulin G elution in protein A chromatography employing the method of chromatofocusing for reducing the co-elutio
Comparison of purification strategies for antibodies used in a broad spectrum host cell protein immunoassay.
Cascading effect in bioprocessing-The impact of mild hypothermia on CHO cell behavior and host cell protein composition.
Knockout of a difficult-to-remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoc
A novel approach to characterize host cell proteins associated with therapeutic monoclonal antibodies.
Targeted capture of Chinese hamster ovary host cell proteins: Peptide ligand binding by proteomic analysis.
The agony of choice: Impact of the host animal species on the enzyme-linked immunosorbent assay performance for host cel
High-performance countercurrent membrane purification for host cell protein removal from monoclonal antibody products.
Targeted CHO cell engineering approaches can reduce HCP-related enzymatic degradation and improve mAb product quality.
Comparison of platform host cell protein ELISA to process-specific host cell protein ELISA.
Best practices on critical reagent characterization, qualification, and life cycle management for HCP immunoassays.
Impact of freeze-thaw processes on monoclonal antibody platform process development.
Questioning coverage values determined by 2D western blots: A critical study on the characterization of anti-HCP ELISA r
Improving the analytical toolbox to investigate copurifying host cell proteins presence: N-(4)-(β-acetylglucosaminyl)- l
Purification processes of live virus vaccine candidates expressed in adherent Vero cell lines via multimodal chromatogra
Comprehensive assessment of host cell protein expression after extended culture and bioreactor production of CHO cell li
Towards continuous mAb purification: Clearance of host cell proteins from CHO cell culture harvests via "flow-throu
Displacement to separate host-cell proteins and aggregates in cation-exchange chromatography of monoclonal antibodies.
Characterization and implications of host-cell protein aggregates in biopharmaceutical processing.
"High-risk" host cell proteins (HCPs): A multi-company collaborative view.
Comparison of host cell protein removal by depth filters with diatomaceous earth and synthetic silica filter aids using
High throughput screening for rapid and reliable prediction of monovalent antibody binding behavior in flowthrough mode
Factors affecting product association as a mechanism of host-cell protein persistence in bioprocessing.
Identification and characterization of CHO host-cell proteins in monoclonal antibody bioprocessing.
Holistic analytical characterization and risk assessment of residual host cell protein impurities in an active pharmaceu
Host cell protein networks as a novel co-elution mechanism during protein A chromatography.
Assessing the Adjuvant Potential of Chinese Hamster Ovary Host Cell Proteins Using an In Vitro Dendritic Cell Assay.
Quantitative Analysis Reveals Hitchhiking Drives Polysorbate Hydrolase Persistence Via Host Cell Protein-Antibody Intera
Integration of Single Pass Tangential Flow Filtration and High Performance Countercurrent Membrane Purification for Inte
Elucidation of Proteoforms of Chinese Hamster Ovary (CHO) Phospholipase B-Like 2 (PLBL2) Captured From a Monoclonal Anti
Tailoring polishing steps for effective removal of polysorbate-degrading host cell proteins in antibody purification.
Integrating Affinity Chromatography in the Platform Process for Adenovirus Purification.
Buffer system improves the removal of host cell protein impurities in monoclonal antibody purification.
Multi-lipase gene knockdown in Chinese hamster ovary cells using artificial microRNAs to reduce host cell protein mediat
Multiple Use of Regenerated Depth Filters in Antibody Purification Processes.
Characterization of the co-elution of host cell proteins with monoclonal antibodies during protein A purification.
Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell pro
Accounting for host cell protein behavior in anion-exchange chromatography.
Experience with host cell protein impurities in biopharmaceuticals.
Process characterization strategy for a precipitation step for host cell protein reduction.
Understanding the mechanism of copurification of "difficult to remove" host cell proteins in rituximab biosimi
Effects of pH, conductivity, host cell protein, and DNA size distribution on DNA clearance in anion exchange chromatogra
Mass spectrometric evaluation of upstream and downstream process influences on host cell protein patterns in biopharmace
Identification and tracking of problematic host cell proteins removed by a synthetic, highly functionalized nonwoven med
Precision analysis for the determination of steric mass action parameters using eight tobacco host cell proteins.
Formation of transient highly-charged mAb clusters strengthens interactions with host cell proteins and results in poor
Immunoreactivity profiling of Anti-Chinese hamster ovarian host cell protein antibodies by isobaric labeled affinity pur
Exploring features in chromatographic profiles as a tool for monitoring column performance.
Proteomics analysis of host cell proteins after immobilized metal affinity chromatography: Influence of ligand and metal
Behavior of host-cell-protein-rich aggregates in antibody capture and polishing chromatography.
Biomimetic affinity chromatography for antibody purification: Host cell protein binding and impurity removal.
Leveraging prior knowledge for process parameter classification in mAb Protein A chromatography.
Engineering protein A ligands to mitigate antibody loss during high-pH washes in protein A chromatography.
Purification of a non-enveloped virus using sequential aqueous two-phase extraction.
Hydrophobicity analysis of Chinese Hamster Ovary host cell proteins using analytical hydrophobic interaction chromatogra
Impact of ligand structure and base bead pore size on host cell protein removal during monoclonal antibody purification
Improved clearance of host cell protein impurities at the polishing purification step using multimodal chromatography.
Applications of proteomic methods for CHO host cell protein characterization in biopharmaceutical manufacturing.
Multi-component behavior of host-cell protein- and antibody-containing heteroaggregates in protein A chromatography.
In-house CHO HCPs platform: A promising approach for HCPs ELISA monitoring.
Mitigating polysorbate degradation-induced visible particle formation in an antibody formulation: From root cause identi
Application of the Protein Maker as a platform purification system for therapeutic antibody research and development.
Assessing the polysorbate degradation fingerprints and kinetics of lipases - how the activity of polysorbate degrading h
Sorbitol/methanol mixed induction reduces process impurities and improves centrifugal dewatering in Pichia pastoris cult
SP3-based host cell protein monitoring in AAV-based gene therapy products using LC-MS/MS.
Integrated strategy for deep profiling of host cell proteins in downstream processing of therapeutic monoclonal antibodi
Cathepsin D: Removal strategy on protein A chromatography, near real time monitoring and characterisation during monoclo
SWATH-MS as a strategy for CHO host cell protein identification and quantification supporting the characterization of mA
Host cell protein identification in monoclonal antibody high molecular weight species.
Factors affecting robustness of anion exchange chromatography: Selective retention of minute virus of mice using membran
Monoclonal antibody purification using activated carbon as a replacement for Protein A affinity chromatography.
A combination of multiple LC-MS approaches for the comprehensive characterization of recombinant herpes zoster vaccine.
Application of protein A-modified capillary-channeled polymer polypropylene fibers to the quantitation of IgG in complex
Identification and characterization of co-purifying CHO host cell proteins in monoclonal antibody purification process.
Toward unbiased identification and comparative quantification of host cell protein impurities by automated iterative LC-
Identification of a host cell protein impurity in therapeutic protein, P1.
Host cell protein quantitation by LC-MS. Experimental demonstration, qualification, and comparison of methods in USP 113
Host cell protein quantification of an optimized purification method by mass spectrometry.
l-Asparaginase and HCP quantification by SWATH LC-MS/MS for new and improved purification step in Erwinia chrysanthemil-
Quantitation of host cell proteins in biopharmaceuticals from chinese hamster ovarian and vero cell lines using capillar
Comparison of analytical-flow, micro-flow and nano-flow LC-MS/MS for sub-proteome analysis.
Host cell protein quantification workflow using optimized standards combined with data-independent acquisition mass spec
A custom-made time-resolved fluoroimmunoassay for the quantitation of the host cell protein of Vero in rabies vaccine.
Improved identification of host cell proteins in a protein biopharmaceutical by LC-MS/MS using the ProteoMiner™ Enrichme
Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation
Label-free shotgun proteomics: Exploiting a reliable and sensitive method to monitor residual host-cell proteins in mono
Automated optimization of resin selection, wash parameters, and elution parameters for protein A-based purifications.
Characterization of difficult-to-remove host cell proteins in adeno-associated virus downstream processing.
Effective strategies for host cell protein clearance in downstream processing of monoclonal antibodies and Fc-fusion pro
Quantitative proteomic analysis of residual host cell protein retention across adeno-associated virus affinity chromatog
Beyond viability: Advancing CHO cell culture process strategies to modulate host cell protein levels.
Development of a novel engineered E. coli host cell line platform with improved column capacity performance for ion-exch
Evaluation of spectral libraries and sample preparation for DIA-LC-MS analysis of host cell proteins: A case study of a
Sodium caprylate induced precipitation post Protein A chromatography as an effective means for host cell protein clearan
pH conditioning is a crucial step in primary recovery - A case study for a recombinant Fab from E. coli.
A two-step process for capture and purification of human basic fibroblast growth factor from E. coli homogenate: Yield v
Promiscuity of host cell proteins in the purification of histidine tagged recombinant xylanase A by IMAC procedures: A c
Evaluating the efficacy of immobilized metal affinity chromatography (IMAC) for host cell protein (HCP) removal from ant
Removal of polysorbates degradation-related impurities by depth filter screening: A case study.
The advantage of high pH eluting Protein A resins over their regular counterparts in aggregate and host cell protein cle
The adequate amount of sodium chloride in Protein A wash buffer for effective host cell protein clearance.
Two major mechanisms contributing to copurification of CHO host cell proteins and strategies to minimize their negative
Deciphering the inconsistent performance of Protein A membrane on host cell protein clearance.
Integrated native digestion and molecular weight cutoff enrichment with DIA-MS: a sensitive and selective approach for q
Degradation of Polysorbate 20 by Sialate O-Acetylesterase in Monoclonal Antibody Formulations.
Identification and Quantification of a Problematic Host Cell Protein to Support Therapeutic Protein Development.
Polysorbate Degradation and Particle Formation in a High Concentration mAb: Formulation Strategies to Minimize Effect of
Identification and Characterization of Polysorbate-Degrading Enzymes in a Monoclonal Antibody Formulation.
Improved identification of host cell proteins in monoclonal antibodies by combining filter-aided sample preparation and
A workflow for accurate and consistent quantitation of host cell proteins by SWATH LC-MS/MS analysis to support process
Characterization of Recombinantly-Expressed Hydrolytic Enzymes from Chinese Hamster Ovary Cells: Identification of Host
A Highly Sensitive LC-MS/MS Method for Targeted Quantitation of Lipase Host Cell Proteins in Biotherapeutics.
Host cell protein detection via surfactant-assisted acid precipitation.
Investigating pH Effects on Enzymes Catalyzing Polysorbate Degradation by Activity-Based Protein Profiling.
Identification of Acyl-Protein Thioesterase-1 as a Polysorbate-Degrading Host Cell Protein in a Monoclonal Antibody Form
Elucidating uptake and metabolic fate of dipeptides in CHO cell cultures using 13C labeling experiments and kinetic mode
Fast, Robust, and Sensitive Identification of Residual Host Cell Proteins in Recombinant Monoclonal Antibodies Using Sod
Ultrasensitive Quantification Method for Understanding Biologically Relevant Concentrations of Host Cell Proteins in The
A Novel Sample Preparation for Shotgun Proteomics Characterization of HCPs in Antibodies.
Enhancing Host-Cell Protein Detection in Protein Therapeutics Using HILIC Enrichment and Proteomic Analysis.
Host Cell Protein Profiling by Targeted and Untargeted Analysis of Data Independent Acquisition Mass Spectrometry Data w
Simple and Sensitive Method for Deep Profiling of Host Cell Proteins in Therapeutic Antibodies by Combining Ultra-Low Tr
Combination of FAIMS, Protein A Depletion, and Native Digest Conditions Enables Deep Proteomic Profiling of Host Cell Pr
Standard-Free Absolute Quantitation of Antibody Deamidation Degradation and Host Cell Proteins by Coulometric Mass Spect
Versatile LC-MS-Based Workflow with Robust 0.1 ppm Sensitivity for Identifying Residual HCPs in Biotherapeutic Products.
Native Digestion and Shotgun Proteomics for Host Cell Protein Profiling of Adeno-Associated Viruses.
A 2D LC-MS/MS Strategy for Reliable Detection of 10-ppm Level Residual Host Cell Proteins in Therapeutic Antibodies.
diaPASEF Enables High-Throughput Proteomic Analysis of Host Cell Proteins for Biopharmaceutical Process Development.
Host Cell Protein Profiling in Biopharmaceutical Harvests
Targeted Host Cell Protein Quantification by LC-MRM Enables Biologics Processing and Product Characterization.
Strategy for Generating Sequence-Defined Aptamer Reagent Sets for Detecting Protein Contaminants in Biotherapeutics.
Dual Data-Independent Acquisition Approach Combining Global HCP Profiling and Absolute Quantification of Key Impurities
Sensitive, Rapid, Robust, and Reproducible Workflow for Host Cell Protein Profiling in Biopharmaceutical Process Develop
Evaluation of Peptide Fractionation and Native Digestion as Two Novel Sample Preparation Workflows to Improve HCP Charac
Optimized Sample Preparation and Data Processing of Data-Independent Acquisition Methods for the Robust Quantification o
Proteomics Strategies for Mass Spectrometry Analysis of Host Cell Proteins in Monoclonal Antibody Bioprocessing.
Development of an Optimized LC-MS Workflow for Host Cell Protein Characterization to Support Upstream Process Developmen
Carrier-Guided Proteome Analysis in a High Protein Background: An Improved Approach to Host Cell Protein Identification.
A Novel Strategy to Rapidly Profile and Quantify High-Risk Host Cell Proteins Using Integrated DDA-PRM-dMRM Mode.
High-Risk Host Cell Protein Profiling with Sub-ppm Sensitivity by iRT-Assisted Targeted Mass Spectrometry.
The Dual-Integrated Multi-Attribute Method: Simultaneous Evaluation of Post-Translational Modifications and Host Cell Pr
Systematic Optimization of Activity-Based Protein Profiling for Identification of Polysorbate-Degradative Enzymes in Bio
Tracking the Behavior of Monoclonal Antibody Product Quality Attributes Using a Multi-Attribute Method Workflow.
A modular and adaptive mass spectrometry-based platform for support of bioprocess development toward optimal host cell p
Host cell protein profiling of commercial therapeutic protein drugs as a benchmark for monoclonal antibody-based therape
Technical advancement and practical considerations of LC-MS/MS-based methods for host cell protein identification and qu
ELISA reagent coverage evaluation by affinity purification tandem mass spectrometry.
Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms.
Host Cell Proteins Can Be Eliminated More Strategically
Illuminating a biologics development challenge: systematic characterization of CHO cell-derived hydrolases identified in
Hamster neogenin, a host-cell protein contained in a respiratory syncytial virus candidate vaccine, induces antibody res
Mild hypothermic culture conditions affect residual host cell protein composition post-Protein A chromatography.
Host cell protein detection gap risk mitigation: quantitative IAC-MS for ELISA antibody reagent coverage determination.
Ceramic hydroxyapatite chromatography plays a critical role in bispecific antibody purification process for impurity rem
Evaluating Immunogenicity Risk Due to Host Cell Protein Impurities in Antibody-Based Biotherapeutics.
Improving Chinese hamster ovary host cell protein ELISA using Ella®: an automated microfluidic platform.
Impact of next-generation high productivity perfusion cell culture process on host cell protein profile and a comparison
Development of a One-step Magnetic Separation-based Fluorescent Sandwich Assay for Residual Protein A in Antibody Drugs
Cascading effects in bioprocessing: the impact of cell culture environment on CHO cell behaviour and host cell protein s
Comparison of Tobacco Host Cell Protein Removal Methods by Blanching Intact Plants or by Heat Treatment of Extracts.
An HS-MRM Assay for the Quantification of Host-cell Proteins in Protein Biopharmaceuticals by Liquid Chromatography Ion
Host Cell Protein Analysis using Enrichment Beads Coupled with Limited Digestion.
Comparison of Tobacco Host Cell Protein Removal Methods by Blanching Intact Plants or by Heat Treatment of Extracts.
Process- and product-related impurities in the ChAdOx1 nCov-19 vaccine.
Experimental characterization and prediction of Escherichia coli host cell proteome retention during preparative chromat
A novel approach to evaluate ELISA antibody coverage of host cell proteins-combining ELISA-based immunocapture and mass
Identification and classification of host cell proteins during biopharmaceutical process development.
Development of continuous processing platform utilizing aqueous two-phase extraction for purification of monoclonal anti
Efficient host cell protein clearance: A study of membrane adsorbers and resins in biopharmaceutical processes.
A new deep field scan liquid chromatography-mass spectrometry method to identify host cell proteins in therapeutic prote
Improved Host Cell Protein Analysis in Monoclonal Antibody Products through Molecular Weight Cutoff Enrichment.
Advanced assessment of the physicochemical characteristics of Remicade® and Inflectra® by sensitive LC/MS techniques.
An HS-MRM Assay for the Quantification of Host-cell Proteins in Protein Biopharmaceuticals by Liquid Chromatography Ion
Polysorbates degrading enzymes in biotherapeutics - a current status and future perspectives.
Label-free quantification of host cell protein impurity in recombinant hemoglobin materials
Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug pr
Monitoring process-related impurities in biologics-host cell protein analysis.
Mass spectrometry-based investigation of measles and mumps virus proteome.
Immunoinformatic Risk Assessment of Host Cell Proteins During Process Development for Biologic Therapeutics.
Assessment of the immunogenicity of residual host cell protein impurities of OsrHSA.
Leveraging an advanced simulated moving bed approach to achieve 3-component separation for enhanced impurity removal in
Thermostable chaperone-based polypeptide biosynthesis: Enfuvirtide model product quality and protocol-related impurities
A comparison of SWATH-MS methods for measurement of residual host cell proteins in adeno-associated virus preparations.
Comparative analysis of ChAdOx1 nCoV-19 and Ad26.COV2.S SARS-CoV-2 vector vaccines
In-Line Monitoring of Downstream Purification Processes for VSV Based SARS-CoV-2 Vaccine Using a Novel Technique.
Multiplexed Competitive Screening of One-Bead-One-Component Combinatorial Libraries Using a ClonePix 2 Colony Sorter.
Quantitation of Host Cell Proteins by Capillary LC/IMS/MS/MS in Combination with Rapid Digestion on Immobilized Trypsin
nlewisres@ucsd.edu
Multiplex secretome engineering enhances recombinant protein production and purity.
gyunminlee@kaist.ac.kr
Proteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO Cells.
xuanwen.li@merck.com
Identification and characterization of a residual host cell protein hexosaminidase B associated with N-glycan degradatio
Somar.x.khalil@gsk.com
Definitive benchmarking of DDA and DIA for host cell protein analysis on the Orbitrap Astral in a regulatory-aligned fra
zhang_wei@bti.a-star.edu.sg
Effective flow-through polishing strategies for knob-into-hole bispecific antibodies.
s.alhuthali15@imperial.ac.uk
Population balance modelling captures host cell protein dynamics in CHO cell cultures.
jannis.marzluf@sartorius.com
Towards a cleaner CHO chassis: systematic knockout of host cell proteins for efficient biopharmaceutical manufacturing.
kornecki@itv.tu-clausthal.de
Host Cell Proteins in Biologics Manufacturing: The Good, the Bad, and the Ugly.
johannes.buyel@rwth-aachen.de
A Combined Ultrafiltration/Diafiltration Step Facilitates the Purification of Cyanovirin-N From Transgenic Tobacco Extra
panhongjuan@sinopharm.com
Residual host cell proteins: sources, properties, detection methods and data acquisition modes.
johannes.buyel@ime.fraunhofer.de
Optimized Blanching Reduces the Host Cell Protein Content and Substantially Enhances the Recovery and Stability of Two P
y-hashimoto@fuji-silysia.co.jp
Optimization of Sequence, Display, and Mode of Operation of IgG-Binding Peptide Ligands to Develop Robust, High-Capacity
wxiao@temple.edu
Site-Specific N-Glycosylation on the AAV8 Capsid Protein.
smlemma@ncsu.edu
Nonwoven Ion-Exchange Membranes with High Protein Binding Capacity for Bioseparations.
Kevin_Blackburn@waters.com
Targeted Capture of Chinese Hamster Ovary Host Cell Proteins: Peptide Ligand Discovery.
min.du@thermofisher.com
Applying UHPLC-HRAM MS/MS Method to Assess Host Cell Protein Clearance during the Purification Process Development of Th
liusixu2020@163.com
A Single-Step Method for Harvesting Influenza Viral Particles from MDCK Cell Culture Supernatant with High Yield and Eff
julie.flecheux@univ-lyon1.fr
Scout-Triggered Multiple Reaction Monitoring Enables Robust Quantification of Host Cell Proteins Across Bioprocess Matri
christopher.tubbs@merck.com
Automated, Quantitative Capillary Western Blots to Analyze Host Cell Proteins in COVID-19 Vaccine Produced in Vero Cell
bernier.alice@videotron.ca
A Four-Step Purification Process for Gag VLPs: From Culture Supernatant to High-Purity Lyophilized Particles.
mirandali418@sina.com
Label-Free Quantitative Proteomics Analysis of COVID-19 Vaccines by Nano LC-HRMS.
liyuhua@nifdc.org.cn
Novel Standard Substance from Primary Hamster Kidney Cells for Quality Control of Human Rabies Vaccines in China.