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Temperature Down-Shift Modifies Expression of UPR-/ERAD-Related Genes and Enhances Production of a Chimeric Fusion Prote
Bioinformatic Identification of Chinese Hamster Ovary (CHO) Cold-Shock Genes and Biological Evidence of their Cold-Induc
A Comparative Transcriptomics Workflow for Analyzing Microarray Data From CHO Cell Cultures.
The CAG promoter maintains high-level transgene expression in HEK293 cells.
Temperature-sensitive miR-483 is a conserved regulator of recombinant protein and viral vector production in mammalian c
Model-based investigation of intracellular processes determining antibody Fc-glycosylation under mild hypothermia.
Cascading effect in bioprocessing-The impact of mild hypothermia on CHO cell behavior and host cell protein composition.
Exploring cellular behavior under transient gene expression and its impact on mAb productivity and Fc-glycosylation.
Culture temperature modulates half antibody and aggregate formation in a Chinese hamster ovary cell line expressing a bi
Reduction of IL-2 fragmentation during manufacturing of a novel immunocytokine by DoE process optimization.
Production and characterization of active recombinant human factor II with consistent sialylation.
Identification of process conditions influencing protein aggregation in Chinese hamster ovary cell culture.
Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to
Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothe
Perfusion process combining low temperature and valeric acid for enhanced recombinant factor VIII production.
Kinetic modeling as a tool to understand the influence of cell culture process parameters on the glycation of monoclonal
Exploring the linkage between cell culture process parameters and downstream processing utilizing a plackett-burman desi
Subphysiological temperature induces pervasive alternative splicing in Chinese hamster ovary cells.
Effective temperature shift strategy development and scale confirmation for simultaneous optimization of protein product
Exploring the capabilities of fluorometric online monitoring on chinese hamster ovary cell cultivations producing a mono
Innovating cell culture process development with deep learning-powered robotic experimentation using the first Industria
Differential effects of bioreactor process variables and purification on the human recombinant lysosomal enzyme β-glucur
Synergistic promotion of transient transgene expression in CHO cells by PDI/XBP-1s co-transfection and mild hypothermia.
Reduction of charge variants by CHO cell culture process optimization.
Comparative study of commercial media to improve GMP manufacturing of recombinant human interferon β-1a by CHO cells in
Comparison of different transient gene expression systems for the production of a new humanized anti-HER2 monoclonal ant
EGCG improves recombinant protein productivity in Chinese hamster ovary cell cultures via cell proliferation control.
Combination of temperature shift and hydrolysate addition regulates anti-IgE monoclonal antibody charge heterogeneity in
Applications of proteomic methods for CHO host cell protein characterization in biopharmaceutical manufacturing.
Model-based optimization of temperature and pH shift to increase volumetric productivity of a Chinese hamster ovary fed-
Biphasic cultivation strategy to avoid Epo-Fc aggregation and optimize protein expression.
miRNA profiling of high, low and non-producing CHO cells during biphasic fed-batch cultivation reveals process relevant
Investigating the metabolic load of monoclonal antibody production conveyed to an inducible CHO cell line using a transf
Development of a 10 g/L process for a difficult-to-express multispecific antibody format using a holistic process develo
A novel dynamic flux balance analysis for modeling CHO cell fed-batch cultures with pH and temperature shifts.
Impact of temperature and pH on recombinant human IgM quality attributes and productivity.
Assessment of fed-batch cultivation strategies for an inducible CHO cell line.
CHO genome mining for synthetic promoter design.
Kinetic modeling: A tool for temperature shift and feeding optimization in cell culture process development.
Differential Phosphoproteomic Analysis of Recombinant Chinese Hamster Ovary Cells Following Temperature Shift.
Proteome-Wide Analysis of N-Glycosylation Stoichiometry Using SWATH Technology.
Mild hypothermic culture conditions affect residual host cell protein composition post-Protein A chromatography.
Systematic development of temperature shift strategies for Chinese hamster ovary cells based on short duration cultures
Development and Qualification of a Scale-Down Mammalian Cell Culture Model and Application in Design Space Development b
The Effect of Culture Temperature on the Aggregation of Recombinant TNFR-Fc is Regulated by the PERK-eIF2a Pathway in CH
Optimization of Culture Conditions to Improve Follicle-Stimulating Hormone Production by CHO-DG44 Cells in Serum-Free Me
Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells.
Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Producti
Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells.
Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling
takors@ibvt.uni-stuttgart.de
Optimum blue light exposure: a means to increase cell-specific productivity in Chinese hamster ovary cells.
jianlin.xu@bms.com
Development of an intensified fed-batch production platform with doubled titers using N-1 perfusion seed for cell cultur
Maleknias@aryogen.com
Therapeutic Fc fusion protein misfolding: A three-phasic cultivation experimental design.
j.s.donaldson@sms.ed.ac.uk
Decoupling Growth and Protein Production in CHO Cells: A Targeted Approach.
claudia.altamirano@pucv.cl
High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat
shahbazimajid@yahoo.co.uk
Enhancing productivity of Chinese hamster ovary (CHO) cells: synergistic strategies combining low-temperature culture an
kamihira@chem-eng.kyushu-u.ac.jp
High-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loo