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The Impact of Culture Variables on a 3D Human In Vitro Bone Remodeling Model: A Design of Experiments Approach
Pyomo.DOE : An open‐source package for model‐based design of experiments in Python
Continuous precipitation of process related impurities from clarified cell culture supernatant using a novel coiled flow
Using prior parameter knowledge in model‐based design of experiments for pharmaceutical production
Advancing Cellular-Specific Delivery: Machine Learning Insights into Lipid Nanoparticles Design and Cellular Tropism.
High recovery of intracellular recombinant HBsAg from Pichia pastoris via continuous pulsed laser cell disruption system
Optimization of thermophilic trans-isoprenyl diphosphate synthase expression in Escherichia coli by response surface met
Comparison of Modeling Methods for DoE-Based Holistic Upstream Process Characterization.
Hybrid Modeling and Intensified DoE: An Approach to Accelerate Upstream Process Characterization.
Optimization of muscle cell culture media using nonlinear design of experiments.
Reducing water uptake into BY-2 cells by systematically optimizing the cultivation parameters increases product yields a
Defined Serum-Free Medium for Bioreactor Culture of an Immortalized Human Erythroblast Cell Line.
Simplex-based optimization of numerical and categorical inputs in early bioprocess development: Case studies in HT chrom
Toward Machine Learning-Guided CHO Bioprocess and Media Optimization for Improved Titer and Glycosylation.
Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided
Identification of process conditions influencing protein aggregation in Chinese hamster ovary cell culture.
Hyperthermic shift and cell engineering increase small extracellular vesicle production in HEK293F cells.
Model-assisted process characterization and validation for a continuous two-column protein A capture process.
Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody-peptide
Addressing amino acid-derived inhibitory metabolites and enhancing CHO cell culture performance through DOE-guided media
Red cell manufacturing using parallel stirred-tank bioreactors at the final stages of differentiation enhances reticuloc
UHPLC Method Development for the Trace Level Quantification of Anastrozole and Its Process-Related Impurities Using Desi
Design of transfections: Implementation of design of experiments for cell transfection fine tuning.
Quality by design approach to improve quality and decrease cost of in vitro transcription of mRNA using design of experi
Toward intensifying design of experiments in upstream bioprocess development: An industrial <i>Escherichia coli</i> feas
Integrating Ensemble NSGA-II for Multi-Objective Process Optimization: Refolding of Proinsulin as a Case Study.
Effect of pH, NaCl concentration, and mAb concentration of feed solution on the filterability of Planova™ 20N and Planov
Application of simplex-based experimental optimization to challenging bioprocess development problems: Case studies in d
At-line raman spectroscopy and design of experiments for robust monitoring and control of miniature bioreactor cultures.
Optimizing glutamine concentration enhances ex vivo expansion of natural killer cells through improved redox status.
Data-driven multi-objective optimization via grid compatible simplex technique and desirability approach for challenging
Characterization of a Saccharomyces cerevisiae fermentation process for production of a therapeutic recombinant protein
Efficient optimization of time-varying inputs in a fed-batch cell culture process using design of dynamic experiments.
Traces matter: Targeted optimization of monoclonal antibody N-glycosylation based on/by implementing automated high-thro
Trace metal optimization in CHO cell culture through statistical design of experiments.
Crosslinked Aggregates of Fusion Enzymes in Microaqueous Organic Media.
Design of experiments applications in bioprocessing: Chromatography process development using split design of experiment
Reusing wastewater from Coffea arabica processing to produce single-cell protein using Candida sorboxylosa: Optimizing o
Enhancing the performance of an in vitro RNA biosensor through iterative design of experiments.
Tailoring Natural Solvents: Deep Eutectic Approach for Recovering Bioactives From Prunus spinosa L.
Statistical Design of Experiments for Screening and Optimization
Design of Experiments: A comparison study from the non‐expert user's perspective
Treatment of Pulp Black Liquor with an Ionic Liquid: Modeling and Optimization by Using Response Surface Methodology and
Sustainability-Driven Accelerated Shear-Mediated Immunoassay for Amyotrophic Lateral Sclerosis Detection.
Applying intensified design of experiments to mammalian cell culture processes.
Intensified design of experiments for upstream bioreactors.
DoE-based validation of a HPLC-UV method for quantification of rotigotine nanocrystals: Application to in vitro dissolut
Design of experiments-based high-throughput strategy for development and optimization of efficient cell disruption proto
Lignocellulose Treatment Using a Flow-Through Variant of OrganoCat Process.
Employing QbD strategies to assess the impact of cell viability and density on the primary recovery of monoclonal antibo
Optimizing selectivity of anion hydrophobic multimodal chromatography for purification of a single-chain variable fragme
An improved high cell density cultivation-iHCDC-strategy for leucine auxotrophic Escherichia coli K12 ER2507.
Influenza A Virus Production Following Quality by Design Principles.
Towards electroenzymatic processes involving old yellow enzymes and mediated cofactor regeneration.
Optimization of capillary zone electrophoresis for charge heterogeneity testing of biopharmaceuticals using enhanced met
Design of experiments for development and optimization of a liquid chromatography coupled to tandem mass spectrometry bi
Optimizing Tissue-Engineered Periosteum Biochemical Cues to Hasten Bone Allograft Healing.
Determination of the clean-up efficiency of the solid-phase extraction of rosemary extracts: Application of full-factori
HPLC-electrospray ionization-mass spectrometry optimization by high-performance design of experiments for astrocyte glut
Evaluation of Analytical Quality by Design Approaches on the Development and Optimization of Size Exclusion Chromatograp
Biotechnological Control of Hydrogel Properties via Recombinant Protein Molecular Weight Engineering.
Dual-Template Imprinted Polyaniline Designed by Response Surface Methodology.
Design of experiments approach for systematic optimization of a single-shot diaPASEF plasma proteomics workflow applicab
Automated statistical experimental design approach for rapid separation of coenzyme Q10 and identification of its biotec
Enrichment of Kaempferol-3-O-Sophoroside From Saffron Petals Using Macroporous Resin: Static Adsorption Characteristics
Machine learning and Design of Experiments: Alternative approaches or complementary methodologies for quality improvemen
Robust parameter design of human induced pluripotent stem cell differentiation protocols defines lineage-specific induct
Human prorenin determination by hybrid immunocapture liquid chromatography/mass spectrometry: A mixed-solvent-triggered
Improving waste activated sludge dewaterability with sodium periodate pre‐oxidation on extracellular polymeric substance
I-Optimal design of poly(lactic-co-glycolic) acid/hydroxyapatite three-dimensional scaffolds produced by thermally induc
Strategies for sequential design of experiments and augmentation
Efficient Optimization of Process Strategies with Model-Assisted Design of Experiments.
Yarrowia lipolytica Bioprocess Development: From Flask to Bioreactor.
Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cel
Step-By-Step Standardization of the Bottom-Up Semi-Automated Nanocrystallization of Pharmaceuticals: A Quality By Design
Microplate-Based Method for High-Throughput Screening (HTS) of Chromatographic Conditions Studies for Recombinant Protei
Fractional Factorial Designs: An Underutilized Tool for Rapid In Vitro System Development.
Digital Twins and Their Role in Model-Assisted Design of Experiments.
High-Throughput Process Development: II-Membrane Chromatography.
Simultaneous detection of nicotinamide adenine nucleotides and adenylate pool to quantify redox and energy states in mAb
Optimisation of electrochemical sensors based on molecularly imprinted polymers: from OFAT to machine learning.
Overcoming hydrolysis of raw corn starch under industrial conditions with Bacillus licheniformis ATCC 9945a α-amylase.
The importance of factorial design on the optimization of biosensor performance: immobilization of glucose oxidase as a
Stepwise optimization of recombinant protein production in Escherichia coli utilizing computational and experimental app
Lysis and IB washing procedures significantly impact the recovery of rHumanized ranibizumab from inclusion bodies expres
Application of Response Surface Methodology For Modeling and Optimization of A Bio Coagulation Process (Sewage Wastewate
Process mapping and optimization study of CHO cell cultures for mAb production using Ambr® 250 high-throughput parallel
Upstream development of Escherichia coli fermentation process with PhoA promoter using design of experiments (DoE).
Application of experimental design as a statistical approach to recover bioactive peptides from different food sources.
Optimization of ultrasound-assisted production of ergosterol from Penicillium brevicompactum by Taguchi statistical meth
Optimization of o-Chlorophenol Biodegradation by Combined Mycelial Pellets Using Response Surface Methodology
Comprehensive Optimization of LC-MS Metabolomics Methods Using Design of Experiments (COLMeD).
Production and optimization of biodiesel using mixed immobilized biocatalysts in packed bed reactor.
Optimisation of critical medium components and culture conditions for enhanced biomass and lipid production in the oleag
Enhancement of Aeribacillus pallidus strain VP3 lipase catalytic activity through optimization of medium composition usi
Optimization of Soluble Expression and Purification of Recombinant Human Rhinovirus Type-14 3C Protease Using Statistica
Process Optimization for Biosurfactant Production by Bacillus aryabhattai SPS1001 using Taguchi Method.
Analyzing the Impact of Physicochemical Factors on Chlorella vulgaris Growth Through Design of Experiment (DoE) for Carb
Design of Experiments As a Tool for Optimization in Recombinant Protein Biotechnology: From Constructs to Crystals.
Toward the Development of a Biosimilar Variant of Glucarpidase (Carboxypeptidase G2): Secretory Production, Optimization
Response surface optimization of ultrasound-assisted protein extraction from Spirulina platensis: investigation of the e
An Experimental Design to Evaluate the Effects of Process and Formulation on the Viability and Efficacy of L. reuteri En
Design of experiments (DoE) to model phenolic compounds recovery from grape pomace using ultrasounds.
Quality-by-design principles applied to the development and optimisation of lidocaine-loaded dissolving microneedle arra
The role of statistical methods in optimizing and enhancing fungal chitosan commercial production.
A high-resolution multi-attribute method for product characterization, process characterization, and quality control of
Boosting model performance and interpretation by entangling preprocessing selection and variable selection.
Enantioseparation of tropic acid by biphasic enantioselective liquid-liquid extraction: Experimental and simulation.
Development and validation of mathematical models for testing antifungal activity of different essential oils against Ca
Economical production of agricultural γ-polyglutamic acid using industrial wastes by Bacillus subtilis
Evaluation of a DoE based approach for comprehensive modelling of the effect of lipid nanoparticle composition on nuclei
Process optimization of the polyhydroxybutyrate production in the cyanobacteria Synechocystis sp. and Synechococcus sp.
An improvement of surfactin production by B. subtilis BBG131 using design of experiments in microbioreactors and continu
Reliable protocol using gradient boosting decision tree with limited experimental data to modify membrane surface for en
Optimization and kinetic study of ultrasonic assisted esterification process from rubber seed oil.
Simultaneous production of amylases and proteases by Bacillus subtilis in brewery wastes
Lipase production from Fusarium incarnatum KU377454 and its immobilization using Fe3O4 NPs for application in waste cook
Engineering spray-dried rosemary extracts with improved physicomechanical properties: a design of experiments issue
An iterative approach to statistical optimization of exopolysaccharide produced by fermentation of Aureobasidium pullula
Optimization of solvent-free enzymatic esterification in eutectic substrate reaction mixture.
Exopolysaccharide production from Bacillus velezensis KY471306 using statistical experimental design.
Preparation and characterization of a composite biomaterial including starch micro/nano particles loaded chitosan gel.
Rational design of a scalable bioprocess platform for bacterial cellulose production.
Controlled sulfation of mixed-linkage glucan by Response Surface Methodology for the development of biologically applica
One-step immobilization of chitosanase on microcrystalline cellulose using a carbohydrate binding module family 2.
Morphology and water flux of produced cellulose acetate membranes reinforced by the design of experiments (DOE).
Carboxymethylation of pectin: Optimization, characterization and in-vitro drug release studies.
Accurate definition of control strategies using cross validated stepwise regression and Monte Carlo simulation.
Design of experiments optimization of N,N,N-trimethyl chitosan synthesis using N,N-diisopropylethylamine base.
Optimizing N,N,N-trimethyl chitosan synthesis: A design of experiments (DoE) approach.
A quality by design approach to optimise disulfide-linked hyaluronic acid hydrogels.
Multivariate optimization of ulvan extraction applying Response Surface Methodology (RSM): the case of Ulva lactuca L. f
Development of liposomes using formulation by design: Basics to recent advances.
Chemometric evaluation of the combined effect of temperature, pressure, and co-solvent fractions on the chiral separatio
Combination of partial least squares regression and design of experiments to model the retention of pharmaceutical compo
The development and qualification of liquid adsorption chromatography for poloxamer 188 characterization.
A simultaneous determination of related substances by high performance liquid chromatography in a drug product using qua
High throughput process development workflow with advanced decision-support for antibody purification.
Monitoring leachables from single-use bioreactor bags for mammalian cell culture by dispersive liquid-liquid microextrac
SPE-LC-MS/MS optimisation using response surface methodology for quantification of pharmaceuticals, pesticides and organ
The application of design of experiments and artificial neural networks in the evaluation of the impact of acidic condit
Optimization and troubleshooting of preparative liquid chromatography using statistical design of experiments: Four smal
Evaluation of solvent systems for optimized extractables studies of single use bioprocessing solutions.
Streamlining cation exchange chromatography process development for therapeutic monoclonal antibody purification.
Application of design of experiments to optimize the separation of lipid-related compounds in supercritical fluid chroma
Optimization of peptide-plasmid DNA vectors formulation for gene delivery in cancer therapy exploring design of experime
Bioremediation of chlorpyrifos contaminated soil by two phase bioslurry reactor: Processes evaluation and optimization b
Key reaction components affect the kinetics and performance robustness of cell-free protein synthesis reactions.
Application of experimental design and derivative spectrophotometry methods in optimization and analysis of biosorption
Image dataset: Optimizing growth of nonembryogenic citrus tissue cultures using response surface methodology.
Global Sensitivity Analysis as Good Modelling Practices tool for the identification of the most influential process para
Process optimization by use of design of experiments: Application for liposomalization of FK506.
Estimation of design space for an extrusion-spheronization process using response surface methodology and artificial neu
Advancing forced degradation studies: Design of experiments for enhanced structure-function relationship analysis in bio
Improving extracellular vesicles production through a Bayesian optimization-based experimental design.
Design-of-experiments based development and in vitro evaluation of a cationic lipid-based triple adjuvanted subunit pert
The influence of cetomacrogol ointment processing on structure: A definitive screening design.
Design of experiments approach for the development of a validated method to determine the exenatide content in poly(lact
Optimizing spray-dried liposomes for pulmonary delivery: impact of lipids composition and of drying parameters using exp
Biodegradable Electrospun Nanofibers: A New Approach For Rhinosinusitis Treatment.
Human intestinal fluid factors affecting intestinal drug permeation in vitro.
Designing the design of experiments (DOE) – An investigation on the influence of different factorial designs on the char
Miniaturized screening and performance prediction of tailored subcutaneous extended-release formulations for preclinical
Predicting and validating surfactant performance in nanocrystal stabilization using multi-criteria decision analysis and
Comparing design of experiments and optimal experimental design techniques for modelling the microbial growth rate under
Evaluation of cysteine ethyl ester as efficient inducer for glutathione overproduction in Saccharomyces spp.
Production of xylo-oligosaccharides (XOS) of tailored degree of polymerization from acetylated xylans through modelling
Release of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from milk protein isolate (MPI) during enzymatic hydroly
Development of a multiplex forensic identity panel for massively parallel sequencing and its systematic optimization usi
Optimization of culture conditions for Mpt64 synthetic gene expression in Escherichia coli BL21 (DE3) using surface resp
Systematic optimization of culture media for maintenance of human induced pluripotent stem cells using the response surf
Removal of malachite green by polyacrylamide-g-chitosan γ-Fe2O3 nanocomposite-an application of central composite design
Traditional or adaptive design of experiments? A pilot-scale comparison on wood delignification.
Optimization and characterization of PHA from isolate Pannonibacter phragmitetus ERC8 using glycerol waste.
Cd2+ removal efficiency of activated carbon from Prosopis juliflora: Optimization of preparation parameters by the Box-B
Optimization of in vitro refolding conditions of recombinant Lepidium draba peroxidase using design of experiments.
Extraction and antioxidant activities of polysaccharides from roots of Arctium lappa L.
Biological treatment of lignocellulosic biomass by Chaetomium globosporum: Process derivation and improved biogas produc
DOE-based process optimization for development of efficient methods for purification of recombinant hepatitis B surface
Systematic optimization of histidine-tagged enhanced green fluorescent protein (His-EGFP) purification using packed bed
Optimization for simultaneous enhancement of biobutanol and biohydrogen production
Extraction, characterization and biological activity of sulfated polysaccharides from seaweed Dictyopteris divaricata.
Optimization of process using carboxymethyl chitosan for the removal of mixed heavy metals from aqueous streams.
Production and optimization of high grade cellulase from waste date seeds by Cellulomonas uda NCIM 2353 for biohydrogen
Solid Lipid Nanoparticle assemblies (SLNas) for an anti-TB inhalation treatment-A Design of Experiments approach to inve
Quality by Design approach for studying the impact of formulation and process variables on product quality of oral disin
The application of machine learning algorithms in understanding the effect of core/shell technique on improving powder c
Optimization of ciprofloxacin complex loaded PLGA nanoparticles for pulmonary treatment of cystic fibrosis infections: D
Carvacrol/clay hybrids loaded into in situ gelling films.
Use of a temperature ramp approach (TRA) to design an optimum and robust freeze-drying process for pharmaceutical formul
Effects of ionic interactions on protein stability prediction using solid-state hydrogen deuterium exchange with mass sp
Process optimization of twin-screw melt granulation of fenofibrate using design of experiment (DoE).
Rheological temperature sweeping in a quality by design approach for formulation development and optimization.
Stabilization of HSV-2 viral vaccine candidate by spray drying.
A Design of Experiment (DoE) approach to optimise spray drying process conditions for the production of trehalose/leucin
Probabilistic modeling of an injectable aqueous crystalline suspension using influence networks.
Pectin microparticles for peptide delivery: Optimization of spray drying processing.
Proof of concept of a predictive model of drug release from long-acting implants obtained by fused-deposition modeling.
Encapsulation of a highly hydrophilic drug in polymeric particles: A comparative study of batch and microfluidic process
Development and optimization of microfluidic assisted manufacturing process to produce PLGA nanoparticles.
Spray layering of human immunoglobulin G: Optimization of formulation and process parameters.
Modeling of a spray drying method to produce ciprofloxacin nanocrystals inside the liposomes utilizing a response surfac
Optimising the production of PLGA nanoparticles by combining design of experiment and machine learning.
Comparative analysis of tablet dissolution behavior: Batch vs. Continuous direct compression.
Critical process parameters of gelatin microparticle fabrication with a water-in-oil emulsion method.
Quality by design for Niosome-Based nanocarriers to improve transdermal drug delivery from lab to industry.
Scalable microfluidic method for tunable liposomal production by a design of experiment approach.
Automated process development with pure API filling using vacuum drum.
A multi-step machine learning approach for accelerating QbD-based process development of protein spray drying.
A quality-by-design strategic approach for the development of bedaquiline-pretomanid nanoparticles as inhalable dry powd
Quality-by-digital-design for the in-process integration of Raman spectroscopy as a PAT tool in continuous manufacturing
Systematic formulation optimisation to enhance buffer exchange recovery and storage stability for adeno-associated virus
Integration of Bayesian optimization and solution thermodynamics to optimize media design for mammalian biomanufacturing
Controlling neural territory patterning from pluripotency using a systems developmental biology approach.
Process optimization and kinetic modelling of cyclic (1→3, 1→6)-β-glucans production from Bradyrhizobium japonicum MTCC1
Optimisation of enzyme cascades for chiral amino alcohol synthesis in aid of host cell integration using a statistical e
Sequential active learning for medium optimization in mAb production.
Systematic screening for the biocatalytic hydration of fatty acids from different oily substrates by Elizabethkingia men
Design of experiments-based RP - HPLC bioanalytical method development for estimation of Rufinamide in rat plasma and br
Coupling metabolomics analysis and DOE optimization strategy towards enhanced IBDV production by chicken embryo fibrobla
Effectively removing the homodimer in bispecific antibodies by weak partitioning mode of anion exchange chromatography.
Statistical experimental designs to optimize the transient transfection of HEK 293T cells and determine a transfer crite
Accelerated development of a SEC-HPLC procedure for purity analysis of monoclonal antibodies using design of experiments
A case study application of AQbD to the re-development and validation of an affinity chromatography analytical procedure
Model assisted comparison of Protein A resins and multi-column chromatography for capture processes.
Broad application and optimization of a single wash-step for integrated endotoxin depletion during protein purification.
Efficient host cell protein clearance: A study of membrane adsorbers and resins in biopharmaceutical processes.
The use of design of experiments with multiple responses to determine optimal formulations for in vivo hepatic mRNA deli
Biphasic cultivation strategy to avoid Epo-Fc aggregation and optimize protein expression.
Optimization and validation of analytical affinity chromatography for the in-process monitoring and quantification of pe
Nanoparticles laden In situ gel for sustained drug release after topical ocular administration
Design of experiments as a decision tool for cell therapy manufacturing.
Combined Homogeneous Surface Diffusion Model - Design of experiments approach to optimize dye adsorption considering bot
Optimization of co-culture inoculated microbial fuel cell performance using response surface methodology.
Optimization of laccase production from Aspergillus flavus by design of experiment technique: Partial purification and c
Development of FAcE (Formulated Alhydrogel competitive ELISA) method for direct quantification of OAg present in Shigell
Renewal of an old European Pharmacopoeia method for Terazosin using modeling with mass spectrometric peak tracking.
Quality by Design oriented development of hydrophilic interaction liquid chromatography method for the analysis of amitr
Supercritical fluid chromatography approach for a sustainable manufacture of new stereoisomeric anticancer agent.
Development of an integrated chromatographic system for ω-transaminase-IMER characterization useful for flow-chemistry a
Optimization of a liquid chromatography method for the analysis of related substances in daclatasvir tablets using desig
A Quality by Design (QbD) approach to the development of a gradient high-performance liquid chromatography for the simul
When it is too much: Identifying butamben excess on the surface of pharmaceutical preformulation samples by Raman mappin
Analytical method development supported by DoE-DS approach for enantioseparation of (S,S)- and (R,R)-moxifloxacin.
Enhancing analytical development in the pharmaceutical industry: A DoE-QSRR model for virtual Method Operable Design Reg
Validated mass spectrometric assay for the quantification of substance P and human hemokinin-1 in plasma samples: A desi
Predicting liquid chromatography-electrospray ionization/mass spectrometry signal from the structure of model compounds
Application of experimental design in HPLC method optimisation for the simultaneous determination of multiple bioactive
Membrane-based steric exclusion chromatography for the purification of a recombinant baculovirus and its application for
Tuning the performance of a TphR-based terephthalate biosensor with a design of experiments approach.
Optimization of heterologous production of Bacillus ligniniphilus L1 laccase in Escherichia coli through statistical des
Optimization of rabies virus production in neuroblastoma cells using quality by design principles for vaccine and diagno
Establishment of a cell-free multi-enzyme cascade for the synthesis of UDP-GalNAc.
Maximizing the recovery of the native p28 bacterial peptide with improved activity and maintained solubility and stabili
Optimisation of DNA electroporation protocols for different plant-associated bacteria.
Micrometric DNA/PEI polyplexes correlate with higher transient gene expression yields in HEK 293 cells.
Analytical approach for identification and mechanistic insights into mRNA-lipid adduct formation.
PCL foamed scaffolds loaded with 5-fluorouracil anti-cancer drug prepared by an eco-friendly route.
Unlocking DOE potential by selecting the most appropriate design for rAAV optimization.
Harnessing design of experiments and automation significantly improves transient protein production in Chinese hamster o
Combination of PAT and mechanistic modeling tools in a fully continuous powder to granule line: Rapid and deep process u
Improving the heterologous expression of human β-defensin 2 (HBD2) using an experimental design.
Parametric optimization of solvent extraction of Jatropha curcas seed oil using design of experiment and its quality cha
A comparison of statistical approaches used for the optimization of soluble protein expression in Escherichia coli.
Optimization of the enrichment medium for recombinant ChIL-4-ChIL-2 in Lactococcus lactis through response surface metho
Development and optimization of modified nucleosides and deoxynucleosides simultaneous extraction with the use of Design
Optimising cell-based bioassays via integrated design of experiments (ixDoE) - A practical guide.
Improving an rRNA depletion protocol with statistical design of experiments.
Development and validation of a copper ligand-exchange chromatographic method for the estimation of D-lactic acid in Rin
Improving the reaction mix of a Pichia pastoris cell-free system using a design of experiments approach to minimise expe
Automated H2O2 monitoring during photo-Fenton processes using an Arduino self-assembled automatic system.
Optimization of extraction conditions for LC-ToF-MS analysis of mevalonate pathway metabolites in engineered E. coli str
Optimization of the castor fruit biomass chemical delignification by implementing the response surface methodology.
Defining the multiplicity and time of infection for the production of Zaire Ebola virus-like particles in the insect cel
Improving sensitivity for the targeted LC-MS/MS analysis of the peptide bradykinin using a design of experiments approac
Polyethylenimine mediated recovery of SARS-CoV-2 and total viral RNA: Impact of aqueous conditions on behaviour and reco
Combined semi-empirical screening and design of experiments (DOE) approach to identify candidate formulations of a lyoph
Accelerating bioprocess development by analysis of all available data: A USP case study.
Targeting phosphorus recovery strategies for activated sludge: DoE and multi-objective optimisation to analyse key proce
An Experimental-Based Approach to Construct the Process Design Space of a Freeze-Drying Process: An Effective Tool to De
Application of advanced quantification techniques in nanoparticle-based vaccine development with the Sf9 cell baculoviru
Near-Infrared Spectroscopy to Determine Residual Moisture in Freeze-Dried Products: Model Generation by Statistical Desi
Increasing the Robustness of Biopharmaceutical Precipitation Assays - Part I: Derivative UV Spectrophotometric Method De
Algorithm-Based Liquid Formulation Development Including a DoE Concept Predicts Long-Term Viral Vector Stability.
Preparation of Nanoemulsions by Premix Membrane Emulsification: Which Parameters Have a Significant Influence on the Res
Material-Sparing Approach using Differential Scanning Calorimeter and Response Surface Methodology for Process Optimizat
Formulation Development of Doxycycline-Loaded Lipid Nanocarriers using Microfluidics by QbD Approach.
Thermodynamics-based Metabolite Sensitivity Analysis in metabolic networks.
Iterative algorithm-guided design of massive strain libraries, applied to itaconic acid production in yeast.
I-Optimal Design of Hierarchical 3D Scaffolds Produced by Combining Additive Manufacturing and Thermally Induced Phase S
Predictive Model for the Design of Zwitterionic Polymer Brushes: A Statistical Design of Experiments Approach.
Microfluidic Manufacturing of Liposomes: Development and Optimization by Design of Experiment and Machine Learning.
Generalized Subset Designs in Analytical Chemistry.
Optimization of a Dissolvable Lipid Nanoparticle Microneedle Formulation for mRNA Delivery Using Design of Experiments.
Continuous Processing for Manufacturing of Antibody-Drug Conjugates (ADCs).
Rapid Method Development in Hydrophilic Interaction Liquid Chromatography for Pharmaceutical Analysis Using a Combinatio
Chemometrics-Assisted Enhancement of Electrochemical Biosensor Performance toward miRNA Detection.
Plasmid DNA Delivery Using a Stable Nanovesicle Platform: A Design-of-Experiments-Guided Investigation.
A Design of Experiment Rational Optimization of the Degumming Process and Its Impact on the Silk Fibroin Properties
Crystallization Diagram for Antisolvent Crystallization of Lactose: Using Design of Experiments To Investigate Continuou
Comparative Study on Adaptive Bayesian Optimization for Batch Cooling Crystallization for Slow and Fast Kinetic Regimes.
Factorial Design of Experiments to Optimize Multiple Protein Delivery for Cardiac Repair.
Sequential Model-Based A-Optimal Design of Experiments When the Fisher Information Matrix Is Noninvertible
The Promising Prospective Technology for Biofuel Production with Mixed Cultures Using Sorghum Grain (Sorghum bicolor (L.
Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach
Implementation and Application of Model-Based Design of Experiments in a Flowsheet Simulator
Closed-Loop Model-Based Design of Experiments for Kinetic Model Discrimination and Parameter Estimation: Benzoic Acid Es
The Skin You Are In: Design-of-Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human
Efficient Process Development of Abiraterone Acetate by Employing Design of Experiments.
Optimization of Lipid Nanoparticles for saRNA Expression and Cellular Activation Using a Design-of-Experiment Approach.
High-Throughput Automated Design of Experiment (DoE) and Kinetic Modeling to Aid in Process Development of an API
Stability-Focused Nanoparticle Development: Applying Particle Size Stability as a Response Factor in the Design of Exper
From Synthesis to Application: Functionalized Magnetic Nanoparticles as a Simple and Reliable Tool for Nucleic Acid Puri
Flash Thermal Racemization of Chiral Amine in Continuous Flow: An Exploration of Reaction Space Using DoE and Multivaria
A Customized Bayesian Algorithm to Optimize Enzyme-Catalyzed Reactions.
Development of High-Performance Whole Cell Biosensors Aided by Statistical Modeling.
Design-Build-Test-Learn-Guided Engineering of a Whole-Cell Pyruvate Biosensor Based on a Transcription Factor.
Design of Experiments Methodology to Build a Multifactorial Statistical Model Describing the Metabolic Interactions of A
Double Dutch: A Tool for Designing Combinatorial Libraries of Biological Systems.
Improving Metabolic Pathway Efficiency by Statistical Model-Based Multivariate Regulatory Metabolic Engineering.
A Lactose-Based Kluyveromyces lactis Cell-Free Protein Synthesis System.
Engineering Polymer-Lipid Integrated Nanoparticles with Quantitative Design Principles for Organ-Selective mRNA Delivery
In vitro cell culture in hollow microfibers with porous structures.
Genome Insight and factorial design to elucidate the regulation of the tryptophan-mediated IAA biosynthetic pathway in a
Customized hydrogel substrates for serum-free expansion of functional hMSCs.
A DoE-guided development and validation of a novel HPLC method for determining N-acetylmuramoyl-L-alanine amidase activi
Design of experiments (DoE) to develop and to optimize extraction of psychoactive substances.
Bayesian Design of Experiments Using Approximate Coordinate Exchange
Adaptive Design of Experiments for Conservative Estimation of Excursion Sets
Implementation of design of experiments approach for the micronization of a drug with a high brittle-ductile transition
Systematic development of design of experiments (DoE) optimised self-microemulsifying drug delivery system of Zotepine.
Fabrication, optimisation and in vitro evaluation of docetaxel and curcumin Co-loaded nanostructured lipid carriers for
A step forward towards the development of stable freeze-dried liposomes: a quality by design approach (QbD).
Development of separation technology for the removal of radium-223 from targeted thorium conjugate formulations. Part II
Development of rapidly dissolving pellets within the Quality by Design approach.
Box-Behnken design directed optimization for sensitivity assessment of anti-platelet drugs.
Optimization of gliclazide loaded alginate-gelatin beads employing central composite design.
Formulation and optimization for DPP-4 inhibitor nanomicelles using response surface methodology.
Application of experimental designs and response surface methods in screening and optimization of reverse micellar extra
Development of effective AmB/AmB-αCD complex double loaded liposomes using a factorial design for systemic fungal infect
Enhancing quality-by-design through weighted goal programming: a case study on formulation of ultradeformable liposomes.
Optimally controlled morphology and physico-mechanical properties of inclusion complex loaded electrospun polyvinyl alco
The immobilized Alcaligenes faecalis strain WT14 for removing high strength nitrate and reducing nitrite accumulation
Optimization of biotransformation process for the synthesis of pyrazine-2-carboxylic acid hydrazide using acyltransferas
Optimization of novel and greener approach for the coproduction of uricase and alkaline protease in Bacillus licheniform
Optimization of tetanus toxoid ammonium sulfate precipitation process using response surface methodology.
High-throughput clone screening and upstream process optimization for recombinant therapeutic peptide expression: biosim
Bioprocess optimization of L-glutaminase production by a novel Klebsiella pneumoniae strain SCPRC using response surface
Isolation, identification and optimization of enhanced production of laccase from Galactomyces geotrichum under solid-st
The multiple-response modeling of heat-assisted, microwave-assisted and subcritical water extraction on selected phenoli
Development of a semidefined growth medium for Pedobacter cryoconitis BG5 using statistical experimental design.
Discriminating chemometric analysis to study chemical variation between different altitude Bergenia ciliata (Haw.) Stern
Recovery of anthocyanins from sour cherry (Prunus cerasus L.) peels via microwave assisted extraction: monitoring the st
Selective removal of closely related clipped protein impurities using poly(ethylenimine)- grafted anion-exchange chromat
Optimization of non-detergent treatment for enveloped virus inactivation using the Taguchi design of experimental method
Design of experiments for the optimization of sample preparation for bottom-up targeted protein LC-MS/MS workflows.
Comprehensive manipulation of glycosylation profiles across development scales.
Box–Behnken design for the optimization of the removal of Cr(VI) in soil leachate using nZVI/Ni bimetallic particles
Preparation and Optimization of Leuprolide Acetate Nanoparticles Using Response Surface Methodology: In Vitro and Ex Viv
Design of experiments approach to developing a robust ink for bioprinting.
A fast and simple approach to optimize the unit operation high pressure homogenization - a case study for a soluble ther
Robust freeze-drying process re-design of a legacy product based on risk analysis and design of experiments.
Green and Sustainable Analytical Chemistry-Driven Chromatographic Method Development for Stability Study of Apixaban Usi
Application of Quality Risk Assessment and DoE-Based Enhanced Analytical Quality by Design Approach to Development of Ch
Antagonistic effects of chemical mixtures on the oxidative stress response are silenced by heat stress and reversed unde
Vegan grade medium component screening and concentration optimization for the fermentation of the probiotic strain Lacto
Analytical Quality by Design as an Important Tool to Determine the Best Analytical Conditions for Isoniazid and Its Resp
Red, Green, and Blue Model-Based Assessment and Principles of White Analytical Chemistry to Robust Stability-Indicating
Design and Optimization of a Passive Micromixer with Kite-Shaped Chambers
Improvement Acid Pretreatment of Corn Stover for Efficient Pentose Production
Evolving Neuro-Fuzzy Systems-Based Design of Experiments in Process Identification
High level extracellular production of recombinant human interferon alpha 2b in glycoengineered Pichia pastoris: culture
Lipase Catalyzed Synthesis of ABA‐Type Structured Lipid from Single Cell Oil and Tripalmitin
Biosynthesis of Amyl Alcohol From Scenedesmus quadricauda Microalgae for Light Commercial Vehicle Compression Ignition E
Optimal Design of Experiments for Non-Linear Response Surface Models
Bayesian Optimal Design of Experiments for Inferring the Statistical Expectation of Expensive Black-Box Functions
Applying Statistical Design of Experiments To Understanding the Effect of Growth Medium Components on Cupriavidus necato
Sequential Design of Experiment for Sparse Polynomial Chaos Expansions
23 Full Factorial Model for Particle Size Optimization of Methotrexate Loaded Chitosan Nanocarriers: A Design of Experim
Obtaining Acid-sensitive Prosaikogenin F by Enzymatic Hydrolysis of Saikosaponin A
Optimization of a Colorimetric Assay to Determine Lactate Dehydrogenase B Activity Using Design of Experiments.
A General Guide for the Optimization of Enzyme Assay Conditions Using the Design of Experiments Approach.
Optimization of Concentrated Sulphuric Acid Hydrolysis of Gadam Sorghum Stalks Found in Kenya for Fermentable Sugar Prod
Optimizing the generation of mature bone marrow-derived dendritic cells in vitro: a factorial study design.
Application of DOE to ELISA Robustness and Ruggedness Assessment.
Study of the Influence of Formulation Variables in Bioadhesive Emulgels Using Response Surface Methodology.
Investigating a Novel Hot Melt Extrusion-Based Drying Technique to Solidify an Amorphous Nanosuspension Using Design of
Scale up of Semisolid Dosage Forms Manufacturing Based on Process Understanding: from Lab to Industrial Scale.
Understanding the Effects of Associated Factors in the Development of Microsponge-Based Drug Delivery: a Statistical Qua
A Systematic Approach of Employing Quality by Design Principles: Risk Assessment and Design of Experiments to Demonstrat
A Data-Mining Approach for the Quantitative Assessment of Physicochemical Properties of Molecular Compounds in the Skin
Production of Lysozyme-PLGA-Loaded Microparticles for Controlled Release Using Hot-Melt Extrusion.
Use of a Design of Experiments (DoE) Approach to Optimize Large-Scale Freeze-Thaw Process of Biologics.
Strategizing Spray Drying Process Optimization for the Manufacture of Redispersible Indomethacin Nanoparticles Using Qua
Computational Enhancements to Bayesian Design of Experiments Using Gaussian Processes
Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension.
Loteprednol-Loaded Nanoformulations for Corneal Delivery by Quality-by-Design Concepts: Optimization, Characterization,
The Influence of pH and Preservative Agents on Physicochemical and Microbiological Stability of a Flexible Dose/Age-Appr
Bioprocess Optimization of L-Lysine Production by Using RSM and Artificial Neural Networks from Corynebacterium glutamic
ISOLATION OF PHOSPHATE SOLUBILIZING MICROORGANISMS AND OPTIMIZATION OF THEIR FERMENTATION CONDITIONS BY STATISTICAL TECH
Chemometrics approach for optimization of capillary electrophoretic conditions for the separation of insulin analogues.
Statistical Optimization of Parameters for the Enhancement of Lipase Activity
Introducing an Experimental Design Approach for Efficient Optimization of Chiral Derivatization Conditions for D- and L-
Response surface methodology to optimize inulinase production by a newly isolated Penicillium amphipolaria strain by sol
Evaluation and optimization of ASM1 parameters using large-scale WWTP monitoring data from a subtropical climate region
Process Variables and Design of Experiments in Liposome and Nanoliposome Research
Identifying Optimized Parameters to Enhance the Productivity of Gas Generating Pellets Using a Dome Type Extruder.
Systematic Development and Optimization of an in-situ Gelling System for Moxifloxacin Ocular Nanosuspension using High-p
Simultaneous Optimization of Activity and Stability of Xylose Reductase from D. nepalensis NCYC 3413 Using Statistical E
Optimization of Buffer Additives for Efficient Recovery of hGM-CSF from Inclusion Bodies Using Response Surface Methodol
A New Approach to Modeling Operational Conditions for Mitigating Fouling in Membrane Bioreactor.
β-galactosidase Production by Aspergillus niger ATCC 9142 Using Inexpensive Substrates in Solid-State Fermentation: Opti
Experimental Investigation of Forced Convective Heat Transfer Coefficient & Pressure Drop in Bi-metallic Plate Heat
Extraction of Volatile Fatty Acids from Leachate via Liquidliquid Extraction and Adsorption Method
Produksi Kitosan Berbasis Limbah Udang Delta Mahakam : Tinjauan Proses Deasetilasi
Approach to design space from retrospective quality data.
Quality by design approach: antioxidant activity of the tablets containing cornelian cherry fruits in relation to their
A supermartingale approach to Gaussian process based sequential design of experiments
The Optimization of Sodium Tripolyphosphate Treatment Conditions on the Weight of Giant Freshwater Prawns (Macrobrachium
Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology.
Low-cost cultivation and sporulation of alkaliphilic Bacillus sp. strain AK13 for self-healing concrete.
Chemo-Metric Optimization for Robust and Green Chromatographic Methods
Optimization ultrasonic-microwave-assisted extraction of phenolic compounds from Clinacanthus nutans using response surf
Optimizing the Pomelo Oils Extraction Process by Microwave-Assisted Hydro-Distillation Using Soft Computing Approaches
Metronidazole adsorption on CoFe2O4/activated carbon@chitosan as a new magnetic biocomposite: modelling, analysis, and o
Mathematical Modelling as a Tool to Optimize PHA Production by Massilia spp
Optimization of Effective Minerals on Riboflavin Production by Bacillus subtilis subsp. subtilis ATCC 6051 Using Statist
Optimization of Growth Conditions of Lentinus edodes Mycelium and Polysaccharides on Walnut Shell by-Products Using Resp
Design and optimization of an IgG human ELISA assay reactive to recombinant RBD SARS-CoV-2 protein.
Optimized biosynthesis of bioactive silver nanoparticle-kombucha cellulose nanocomposites for enhanced antimicrobial app
Model-assisted DoE software: optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses.
Efficient design of experiments for sensitivity analysis based on polynomial chaos expansions
Design of experiment (DOE) applied to artificial neural network architecture enables rapid bioprocess improvement.
Statistical investigation of extraction parameters of keratin from chicken feather using Design-Expert.
Enhanced production of thermostable amidase from Geobacillus subterraneus RL-2a MTCC 11502 via optimization of physicoch
Statistical optimization of chitosan-based synthesis strategies to generate albumin nanoparticles.
Modeling and optimization of factors influencing adsorptive performance of agrowaste-derived nanocellulose/iron oxide na
Co-treatment of landfill leachate and municipal wastewater using the ZELIAC/zeolite constructed wetland system.
Mixture design as a tool for improving full-to-empty particle ratios across various GOIs in rAAV production.
Preclinical optimization of an enterotoxigenic Escherichia coli adjuvanted subunit vaccine using response surface design
Parameters influencing the size of chitosan-TPP nano- and microparticles.
A pre-formulation study of tetracaine loaded in optimized nanostructured lipid carriers.
Quality by design approach identifies critical parameters driving oxygen delivery performance in vitro for perfluorocarb
Numerical parametric optimization of fluid flow profiles in membranes using the Taguchi method.
Valorization of wood waste for enhanced polyhydroxybutyrate production by Klebsiella sp. MK3.
Single and multi-objective real-time optimisation of an industrial injection moulding process via a Bayesian adaptive de
Design framework and optimization of portable biomedical waste decomposition systems using ANN and MOPSO.
Multi-response optimization of defined and undefined serum-free media for enhanced proliferation of immortalized lamb mu
Application of a definitive screening design for the synthesis of a charge-transfer complex of sparfloxacin with tetracy
Machine learning and molecular descriptors enable rational solvent selection in asymmetric catalysis.
Statistical Optimization of Hydrazone-Crosslinked Hyaluronic Acid Hydrogels for Protein Delivery.
Development of a fluorescence-based assay for RecBCD activity using functional data analysis and design of experiments.
Self-optimising processes and real-time-optimisation of organic syntheses in a microreactor system using Nelder–Mead and
PEGylated lipid screening, composition optimization, and structure-activity relationship determination for lipid nanopar
Combination of Ultrasound with Ammonification Pretreatment for the Fiber Composition of Corn Straw: a Predictive Model b
Optimization of Bioleaching Process of High-Fluoride-Bearing Uranium by Response Surface Methodology
Optimization of Different Parameter in Synthesis Ion Imprinted Polymers via Precipitation Polymerization for Nitrate Ads
2-[(Hydroxymethyl)amino]ethanol in water as a preservative: Study of formaldehyde released by Taguchi's method
Immobilization of cyclodextrin glucanotransferase on hollow fiber membrane: optimization of the immobilization parameter
Response Surface Methodology for Optimization Studies of Microwave-assisted hydrodistillation of essential oil from Viet
Application of response surface methodology in optimization condition of anthocyanin extraction process of cocoa peel wa
Statistical Optimization of Hydrazone-Crosslinked Hyaluronic Acid Hydrogels for Protein Delivery.
Cell factory for γ-aminobutyric acid (GABA) production using Bifidobacterium adolescentis
Optimization of tenocyte lineage-related factors from tonsil-derived mesenchymal stem cells using response surface metho
Optimization of medium compositions to improve a novel glycoprotein production by Streptomyces kanasenisi ZX01.
Optimization of laccase production from Marasmiellus palmivorus LA1 by Taguchi method of Design of experiments.
Combinatorial engineering pinpoints shikimate pathway bottlenecks in para-aminobenzoic acid production in Pseudomonas pu
Screening for efficient nitrogen sources for overproduction of the biomass of the functionally probiotic L. plantarum st
Optimization and characterization of spray-dried IgG formulations: a design of experiment approach
Preparation, Characterization, and Optimization of Folic Acid-Chitosan-Methotrexate Core-Shell Nanoparticles by Box-Behn
Machine Learning-Enabled NIR Spectroscopy. Part 3: Hyperparameter by Design (HyD) Based ANN-MLP Optimization, Model Gene
Effect of Percent Relative Humidity, Moisture Content, and Compression Force on Light-Induced Fluorescence (LIF) Respons
Optimization Using Response Surface Methodology for Biodiesel Production by Double-Pipe Static Mixer Reactor
Optimization of Low-Temperature Methanol Crystallization for Unsaturated Fatty Acids Separation from Crude Palm Fatty Ac
Optimization of UV irradiation mutation conditions for cellulase production by mutant fungal strains of Aspergillus nige
Design of experiments in liquid chromatography (HPLC) analysis of pharmaceuticals: analytics, applications, implications
Encapsulation of Eucalyptus tereticornis extract in polylactic-co-glycolic acid nanoparticles: standardization, optimiza
Design of Experiments (DoE) applied to Pharmaceutical and Analytical Quality by Design (QbD)
Data-Driven Process Optimization Using AI and Statistical Methods in High-Tech Manufacturing
Developing a Cell Culture Protocol to Induce Quiescence in Intestinal Fibroblasts Using Design of Experiments Statistica
DESIGN OF EXPERIMENTS MODEL FOR THE OPTIMIZATION OF SILK FIBROIN BASED NANOPARTICLES
Biostoning of textile effluent with laccase enzyme
An Alternative Perfusion Approach for the Intensification of Virus-Like Particle Production in HEK293 Cultures.
DoE-based medium optimization for improved biosurfactant production with Aureobasidium pullulans.
Using design of experiments (DoE) to optimize performance and stability of biomimetic cell membrane-coated nanostructure
Process Characterization by Definitive Screening Design Approach on DNA Vaccine Production.
Towards the Experimentally-Informed In Silico Nozzle Design Optimization for Extrusion-Based Bioprinting of Shear-Thinni
Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling
Micronutrient optimization for tissue engineered articular cartilage production of type II collagen.
Perfusion process with tangential flow filtration for oncolytic VSV-GP production.
Optimization of Monascus purpureus for Natural Food Pigments Production on Potato Wastes and Their Application in Ice Lo
High-throughput optimization of antibody production in CHO cells by tuning heavy- and light-chain promoter strength.
Non-edible Oil Cakes as a Novel Substrate for DPA Production and Augmenting Biocontrol Activity of Paecilomyces variotii
Optimizing microwave-assisted extraction of ursolic acid from apple pomace using response surface methodology
3D culture of neural progenitor cells in gelatin norbornene (GelNB) hydrogels: mechanical tuning and hypoxia characteriz
Investigation of Cellular Interactions of Lipid-Structured Nanoparticles With Oral Mucosal Epithelial Cells.
Modeling and Optimizing Culture Medium Mineral Composition for in vitro Propagation of Actinidia arguta.
Combining DOE With Neurofuzzy Logic for Healthy Mineral Nutrition of Pistachio Rootstocks in vitro Culture.
Exploiting the Potential of Bioactive Molecules Extracted by Ultrasounds from Avocado Peels—Food and Nutraceutical Appli
Effect of Zinc-Calcium on Xylose Consumption by Mucor circinelloides (MN128960): Xylitol and Ethanol Yield Optimization
Seed Train Optimization in Microcarrier-Based Cell Culture Post In Situ Cell Detachment through Scale-Down Hybrid Modeli
Chemical Composition, Fatty Acid Profile, and Optimization of the Sacha Inchi (Plukenetia volubilis L.) Seed-Roasting Pr
Supercritical Carbon Dioxide in Presence of Water for the Valorization of Spent Coffee Grounds: Optimization by Response
Exploring the Bioactive Potential of Gracilaria gracilis: An Extraction Optimization Study Using Response Surface Method
Optimization of Protein Extraction of Oenological Interest from Grape Seed Meal Using Design of Experiments and Response
The Role of Machine Learning and Design of Experiments in the Advancement of Biomaterial and Tissue Engineering Research
Production of Polyhydroxyalkanoates through Soybean Hull and Waste Glycerol Valorization: Subsequent Alkaline Pretreatme
Optimization and Validation of an Ultra-Performance Liquid Chromatography with Quadrupole Detector Mass Spectrometry Qua
Optimization of Bromelain-Aided Production of Angiotensin I-Converting Enzyme Inhibitory Hydrolysates from Stone Fish Us
Suitability of Gelatin Methacrylate and Hydroxyapatite Hydrogels for 3D-Bioprinted Bone Tissue.
Towards a Material-by-Design Approach to Electrospun Scaffolds for Tissue Engineering Based on Statistical Design of Exp
Improved Itaconate Production with Ustilago cynodontis via Co-Metabolism of CO2-Derived Formate.
Screening of a Thraustochytrid Strain Collection for Carotenoid and Squalene Production Characterized by Cluster Analysi
Improved Artificial Neural Network Training Based on Response Surface Methodology for Membrane Flux Prediction.
Optimization of Lipopeptide Biosurfactant Production by Salibacterium sp. 4CTb in Batch Stirred-Tank Bioreactors.
Optimization of Medium Constituents for the Production of Citric Acid from Waste Glycerol Using the Central Composite Ro
Design of Experiments for Optimizing Ultrasound-Assisted Extraction of Bioactive Compounds from Plant-Based Sources.
Green Method Comparison and Optimization of Anthocyanin Recovery from "Sangiovese" Grape Pomace: A Critical Ev
Important Aspects of the Design of Experiments and Data Treatment in the Analytical Quality by Design Framework for Chro
QbD-Based Formulation Development of Amiodarone Hydrochloride Tablet.
Lipase-Assisted Synthesis of Alkyl Stearates: Optimization by Taguchi Design of Experiments and Application as Defoamers
Quality by Design (QbD)-Driven Development and Optimization of Tacrolimus-Loaded Microemulsion for the Treatment of Skin
Box–Behnken Design of Experiments of Polycaprolactone Nanoparticles Loaded with Irinotecan Hydrochloride
Application of Design of Experiments in the Development of Self-Microemulsifying Drug Delivery Systems.
Optimized Green Extraction of Polyphenols from Cassia javanica L. Petals for Their Application in Sunflower Oil: Antican
Intensification of Polyphenols Extraction from Eryngium creticum Leaves Using Ired-Irrad® and Evaluation of Antibiofilm
The Use of Response Surface Methodology to Optimize Assisted Extraction of Bioactive Compounds from Cucurbita maxima Fru
Optimization of Polyacrylic Acid Coating on Graphene Oxide-Functionalized Reverse-Osmosis Membrane Using UV Radiation th
Analyzing Homogeneity of Highly Viscous Polymer Suspensions in Change Can Mixers.
Optimization and Modeling of Citrobacter freundii AD119 Growth and 1,3-Propanediol Production Using Two-Step Statistical
Comparison of four functionalization methods of gold nanoparticles for enhancing the enzyme-linked immunosorbent assay (
Challenges and Opportunities in the Process Development of Chimeric Vaccines.
Optimization of Spray Drying Parameters for White Dragon Fruit (Hylocereus undatus) Juice Powder using Response Surface
Self-optimisation and model-based design of experiments for developing a C–H activation flow process
Optimization of biodiesel production from spent cooking oil by fungal lipase using response surface methodology
Statistical Approaches With Emphasis on Design of Experiments Applied to Chemical Processes
Hybridization of Selected Nigerian Lignocellulosic Biomass Feedstocks for Bioethanol Production: Modeling and Optimizati
Isolation and culture medium optimisation using one-factor-at-time and Response Surface Methodology on the biodegradatio
A Taguchi Design of Experiments Approach for Untargeted Metabolomics Sample Preparation Optimization.
Application of Taguchi-Based Design of Experiments for Industrial Chemical Processes
Mun Jun Kim; J. Ahn; S. Kim; Y. Jo; Qing Liu; B. Hwang; M. Lee
mklee@chungbuk.ac.kr
Roger; Schulze, Agnes
agnes.schulze@iom-leipzig.de
Highly Efficient One-Step Protein Immobilization on Polymer Membranes Supported by Response Surface Methodology.
ViewMaria Rosaria
mariarosaria.corbo@unifg.it
Use of Food Spoilage and Safety Predictor for an "A Priori" Modeling of the Growth of Lactic Acid Bacteria in
Viewm.obiedallah@science.sohag.edu.eg
Endophytic Aspergillus fumigatiaffinis: Novel paclitaxel production and optimization insights.
luncui@cczu.edu.cn
Recombinant T7 RNA polymerase production using ClearColi BL21(DE3) and animal-free media for in vitro transcription.
aydin.berenjian@waikato.ac.nz
Optimisation of the fermentation media to enhance the production of the bioactive isomer of vitamin menaquinone-7.
luca.pegoraro.7@phd.unipd.it
Design of experiments and machine learning with application to industrial experiments
u.u.roy@lboro.ac.uk
Tuning Dunaliella tertiolecta for Enhanced Antioxidant Production by Modification of Culture Conditions.
kamil_piwowarek@sggw.pl
Research on the ability of propionic acid and vitamin B12 biosynthesis by Propionibacterium freudenreichii strain T82.
jkleach@ucdavis.edu
Tuning the Microenvironment to Create Functionally Distinct Mesenchymal Stromal Cell Spheroids.
HuuHao.Ngo@uts.edu.au
Influences of operational parameters on phosphorus removal in batch and continuous electrocoagulation process performanc
omar.abdelaziz@kfupm.edu.sa
Oxidative Depolymerization of Lignosulfonates for Muconic Acid Production Using Recombinant Pseudomonas putida CJ475
aref.shokri3@gmail.com
Application of Sono–photo-Fenton process for degradation of phenol derivatives in petrochemical wastewater using full fa
valotta@tugraz.at
3D printed ceramics as solid supports for enzyme immobilization: an automated DoE approach for applications in continuou
briski@ulm.edu
Optimization of Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Mass Spectrometry Detection of Glut
Simone.Rochfort@agriculture.vic.gov.au
Utilisation of Design of Experiments Approach to Optimise Supercritical Fluid Extraction of Medicinal Cannabis
jean-marie.bach@oniris-nantes.fr
Optimization of an O2-balanced bioartificial pancreas for type 1 diabetes using statistical design of experiment.
hmoghimi@ut.ac.ir
Development of a zinc-enriched yeast strain for nutritional applications using low-cost ingredients
andreas.maurer@med.uni-tuebingen.de
A Design of Experiments (DoE) Approach Accelerates the Optimization of Copper-Mediated 18F-Fluorination Reactions of Ary
michael.hummel@aalto.fi
Design of experiments as a tool to guide the preparation of tailor-made activated carbons.
salahinejad@kntu.ac.ir
A new evidence-based design-of-experiments approach for optimizing drug delivery systems with exemplification by emulsio
oliver.bohlen@hm.edu
A multi-stage lithium-ion battery aging dataset using various experimental design methodologies.
xukuan.xu@th-ab.de
AutoML based workflow for design of experiments (DOE) selection and benchmarking data acquisition strategies with simula
zzhu122@163.com
Intelligent information management enables quality-by-design in pharmaceutical production.
mona.arafa@bue.edu.eg
DOE Optimization of Nano-based Carrier of Pregabalin as Hydrogel: New Therapeutic &Chemometric Approaches for Contro
paul.murray@catalysisconsulting.co.uk
The application of design of experiments (DoE) reaction optimisation and solvent selection in the development of new syn
duncan.craig@ucl.ac.uk
Microfluidic synthesis of protein-loaded nanogels in a coaxial flow reactor using a design of experiments approach
advincularc@ornl.gov
Harnessing data and control with AI/ML-driven polymerization and copolymerization.
maj@celonpharma.com
The design of experiments (DoE) in optimization of an aerobic flow Pd-catalyzed oxidation of alcohol towards an importan
guol@jou.edu.cn
Optimization of the Extraction Process of Anti-Vibrio parahaemolyticus Active Substances from Coptidis Rhizoma (Huanglia
oor.ruiter@nottingham.ac.uk
A design of experiments approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) elec
mark.ungrin@ucalgary.ca
Climbing the mountain: experimental design for the efficient optimization of stem cell bioprocessing.
mohadesehabdolvahab@gmail.com
Optimization of a recombinant BlaR-CTD protein formulation using the response surface methodology.
xiajy@tib.cas.cn
Improved production of andrimid in Erwinia persicina BST187 strain by fermentation optimization.
t.w.overton@bham.ac.uk
Use of a design of experiments approach to optimise production of a recombinant antibody fragment in the periplasm of Es
christoph.herwig@tuwien.ac.at
Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed-
t.berkemeier@mpic.de
A numerical compass for experiment design in chemical kinetics and molecular property estimation.
mbukys@trailbio.com
Addressing bioreactor hiPSC aggregate stability, maintenance and scaleup challenges using a design of experiment approac
nigel.scrutton@manchester.ac.uk
Optimising environmental factors for maximal lactate productivity in Synechocystis sp. PCC 6803 through a design of expe
cohan_r@pasteur.ac.ir
Indirect optimization of staphylokinase expression level in dicistronic auto-inducible system.
zhang_wei@bti.a-star.edu.sg
Effective flow-through polishing strategies for knob-into-hole bispecific antibodies.
christoph.wittmann@uni-saarland.de
Defined YNB-free mineral medium improves reproducibility and enables high-titer production in Yarrowia lipolytica.
kareen_coulombe@brown.edu
Practical adoption of state-of-the-art hiPSC-cardiomyocyte differentiation techniques.
hayashi@pha.u-toyama.ac.jp
Determining the Influence of Granule Size on Simulation Parameters and Residual Shear Stress Distribution in Tablets by
a.u.r.mohammed@aston.ac.uk
Design of Experiments to Study the Impact of Process Parameters on Droplet Size and Development of Non-Invasive Imaging
ryan.kramer@idri.org
Development of a thermostable nanoemulsion adjuvanted vaccine against tuberculosis using a design-of-experiments approac
renata.dwornicka@mech.pk.edu.pl
The outline of the expert system for the design of experiment
Pawel_Grzesik@web.de
One-Time Optimization of Advanced T Cell Culture Media Using a Machine Learning Pipeline.
g.mazloom@umz.ac.ir
Modeling and Optimization of Propane Selective Oxidation to Acrylic Acid Over Mo 1 V 0.3 Te 0.23 NB 0.12 O X Catalyst Us
walid.lotfy@pua.edu.eg
Biosynthesis of Silver Nanoparticles by Aspergillus terreus: Characterization, Optimization, and Biological Activities.
vimalprajapati@nau.in
Media formulation using statistical methodology to enhance α-amylase production for green synthesis of Au-NPs by Bacillu
volker.wendisch@uni-bielefeld.de
Enabling and improving trans-nerolidol production by Corynebacterium glutamicum: combining metabolic engineering and tra
cfox@idri.org
Optimizing a Multi-Component Intranasal Entamoeba Histolytica Vaccine Formulation Using a Design of Experiments Strategy
oliveirarv@ufscar.br
Chromatography Conditions Development by Design of Experiments for the Chemotype Differentiation of Four Bauhinia Specie
jasmine.hadjsaadoun@unipr.it
Exploring the Potential of Lactic Acid Fermentation for the Recovery of Exhausted Vanilla Beans.
parisisv@cheng.auth.gr
Comprehensive Exploration of the Growth and Lipid Synthesis Phases of T. oleaginosus Cultures Implementing Design of Exp
gregory.mathy@ucb.com
New Features on the Environmental Regulation of Metabolism Revealed by Modeling the Cellular Proteomic Adaptations Induc
dan.vodnar@usamvcluj.ro
Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Pro
monica.puccini@unipi.it
Optimization of High-Temperature CO2 Capture by Lithium Orthosilicate-Based Sorbents Using Response Surface Methodology
pgallego@uvigo.es
Computer-Based Tools Unmask Critical Mineral Nutrient Interactions in Hoagland Solution for Healthy Kiwiberry Plant Accl
thomas.wucherpfennig@boehringer-ingelheim.com
Lifecycle DoE-The Companion for a Holistic Development Process.
mahwish.aftab@lcwu.edu.pk
Sustainable Endoglucanase Production from Lignocellulosic Waste Through Fungal Co-Culture Technology: A Step Towards Cir
smkim@dongguk.edu
Finite Element Analysis of a Rib Cage Model: Influence of Four Variables on Fatigue Life during Simulated Manual CPR.
shinta.kusumawardani@biofarma.co.id
Defining a Simplified Process in Yeast for Production of Enveloped VLP Dengue Vaccine.
phil.williams@nottingham.ac.uk
A Design of Experiments Approach for Enhancing Room Temperature Stability of a Lyophilised and Paper-Based Bacterial Cel
dcosta@fcsaude.ubi.pt
Maximization of the Minicircle DNA Vaccine Production Expressing SARS-CoV-2 RBD.
barry.ryan@dit.ie
The Statistical Optimisation of Recombinant β-glucosidase Production through a Two-Stage, Multi-Model, Design of Experim
yanliang@nudt.edu.cn
Bayesian Optimization Based on K-Optimality.
mmoldovan@umfcluj.ro
A Design of Experiments Strategy to Enhance the Recovery of Polyphenolic Compounds from Vitis vinifera By-Products throu
damian.smuga@celonpharma.com
Quality by Design (QbD) and Design of Experiments (DOE) as a Strategy for Tuning Lipid Nanoparticle Formulations for RNA
lisa_delouise@urmc.rochester.edu
Optimizing Soluble Cues for Salivary Gland Tissue Mimetics Using a Design of Experiments (DoE) Approach.
maura.ferri@unibo.it
Phytochemicals Recovery from Grape Pomace: Extraction Improvement and Chemometric Study.
m.koubaa@escom.fr
Optimization of cis-9-Heptadecenoic Acid Production from the Oleaginous Yeast Yarrowia lipolytica
r_yasui@yokohama-cu.ac.jp
Clever Experimental Designs: Shortcuts for Better iPSC Differentiation.
lshsieh@thu.edu.tw
Production of Trans-Cinnamic Acid by Immobilization of the Bambusa oldhamii BoPAL1 and BoPAL2 Phenylalanine Ammonia-Lyas
pinteala@icmpp.ro
Optimization of Polyplex Formation between DNA Oligonucleotide and Poly(ʟ-Lysine): Experimental Study and Modeling Appro
guebitz@boku.ac.at
Biocatalyzed Synthesis of Flavor Esters and Polyesters: A Design of Experiments (DoE) Approach.
s.reichl@tu-braunschweig.de
Development of In Vitro Dry Eye Models to Study Proliferative and Anti-Inflammatory Effects of Allogeneic Serum Eye Drop
carmen.carretero@udg.edu
RSM Optimization for the Recovery of Technofunctional Protein Extracts from Porcine Hearts
diana.an.safta@elearn.umfcluj.ro
Optimization of Film-Dressings Containing Herbal Extracts for Wound Care-A Quality by Design Approach.
wsawicki@gumed.edu.pl
A Novel Approach to Optimize Hot Melt Impregnation in Terms of Amorphization Efficiency.
inczedani96@edu.bme.hu
Optimization Workflow of Fumonisin Esterase Production for Biocatalytic Degradation of Fumonisin B1.
vahe.nerguizian@ens.etsmtl.ca
Surface Response Based Modeling of Liposome Characteristics in a Periodic Disturbance Mixer.
whitegra@iu.edu
Optimizing Thermoplastic Starch Film with Heteroscedastic Gaussian Processes in Bayesian Experimental Design Framework.
jennifer.labisch@sartorius.com
Impact of the Membrane Structure of the Stationary Phase on Steric Exclusion Chromatography (SXC) of Lentiviral Vectors.
condurache.bogdan@icmpp.ro
Dynamic Adsorption of a Cationic Dye onto Wool Fibers as Column-Filling Media: Response Surface Optimization and Fixed-B
bernardocarvalho@greencolab.com
Scenedesmus rubescens Heterotrophic Production Strategies for Added Value Biomass.
gul.kozalak@sabanciuniv.edu
Optimization of PLGA Nanoparticle Formulation via Microfluidic and Batch Nanoprecipitation Techniques.
anna.nastruzzi@edu.unife.it
DoE Analysis of Approaches for Hydrogel Microbeads' Preparation by Millifluidic Methods.
cerasel.varaticeanu@icia.ro
Optimization of High-Pressure Extraction Process of Antioxidant Compounds from Feteasca regala Leaves Using Response Sur
yani.aranguren@unisimonbolivar.edu.co
Pigment Production Improvement in Rhodotorula mucilaginosa AJB01 Using Design of Experiments
wangyang2006@nwafu.edu.cn
Response Surface Methodology (RSM) Mediated Optimization of Medium Components for Mycelial Growth and Metabolites Produc
jcoelho@deq.isel.ipl.pt
Microwave-Assisted Extraction of Phenolic Compounds from Spent Coffee Grounds. Process Optimization Applying Design of E
natielledotivo@yahoo.com.br
Biosurfactant-Producing Bacteria Isolated from a Microbial Consortium Previously Subjected to Adaptive Laboratory Evolut
francisco.barba@uv.es
Influence of Temperature, Solvent and pH on the Selective Extraction of Phenolic Compounds from Tiger Nuts by-Products:
scunha@ucp.pt
Bioactive Hydrolysates from Chlorella vulgaris: Optimal Process and Bioactive Properties.
chubert@uliege.be
User-Driven Strategy for In Silico Screening of Reversed-Phase Liquid Chromatography Conditions for Known Pharmaceutical
felix.krujatz@tu-dresden.de
Optimized Protocol for Microalgae DNA Staining with SYTO9/SYBR Green I, Based on Flow Cytometry and RSM Methodology: Exp
rok.dreu@ffa.uni-lj.si
Influence of the Binder Jetting Process Parameters and Binder Liquid Composition on the Relevant Attributes of 3D-Printe
carlos.rodolfo@ubi.pt
Design of Experiments to Achieve an Efficient Chitosan-Based DNA Vaccine Delivery System.
silvia.pescina@unipr.it
Lipid-Based Nanocarriers for Ophthalmic Administration: Towards Experimental Design Implementation.
mpaisana@hovione.com
Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations.
roberta.vitali@enea.it
Design and Manufacturing of Antibacterial Electrospun Polysulfone Membranes Functionalized by Ag Nanocoating via Magnetr
vanderlan.bolzani@unesp.br
Sustainable and Biomimetic Methodology for Extraction of High-Value-Added Compounds in Almond Hulls.
f.harms@martinchrist.de
Model-Based Product Temperature and Endpoint Determination in Primary Drying of Lyophilization Processes.
m.claeys-bruno@univ-amu.fr
Optimization of Solid Lipid Nanoparticle Formulation Using Design of Experiments, PART I: Strategic Tool for the Determi
arkadiusz.adamiszak@student.ump.edu.pl
The Application of the Design of Experiments and Artificial Neural Networks in the Development of a Fast and Straightfor
andriotis@pharm.auth.gr
Quality by Design Micro-Engineering Optimisation of NSAID-Loaded Electrospun Fibrous Patches.
kevin.murnane@lsuhs.edu
Microfluidics-Assisted Formulation of Polymeric Oxytocin Nanoparticles for Targeted Brain Delivery.
dghosh@austin.utexas.edu
Aerosolizable Lipid Nanoparticles for Pulmonary Delivery of mRNA through Design of Experiments.
leovanderpol8@gmail.com
Optimization of Enterovirus-like Particle Production and Purification Using Design of Experiments.
n.kritikos@qualimetrix.com
Determination of Response Factors for Analytes Detected during Migration Studies, Strategy and Internal Standard Selecti
drennen@duq.edu
Quality by Design Methodology Applied to Process Optimization and Scale up of Curcumin Nanoemulsions Produced by Catastr
annamaria.maurelli@isa.cnr.it
Valorization of Turnip Greens (Brassica rapa subsp. sylvestris) Wastes: Investigation on the Sustainable Recovery of Bio
agupta13@amity.edu
QbD-Based Development and Evaluation of Pazopanib Hydrochloride Extrudates Prepared by Hot-Melt Extrusion Technique: In
sarah.lindsay@strath.ac.uk
Can We Simplify Liposome Manufacturing Using a Complex DoE Approach?
gustavo.carapeto@alumni.usp.br
Development of Biopredictive Dissolution Method for Extended-Release Desvenlafaxine Tablets.
margarida.miranda@basi.pt
Rheology of Complex Topical Formulations: An Analytical Quality by Design Approach to Method Optimization and Validation
zhangjiaxiang@ouc.edu.cn
Process Development for the Continuous Manufacturing of Carbamazepine-Nicotinamide Co-Crystals Utilizing Hot-Melt Extrus
natpippa@pharm.uoa.gr
Development of a 3D Printing Liquid Crystal Display (LCD)-Assisted Micromolding Methodology for Custom Fabrication of Po
behnam.taidi@centralesupelec.fr
Optimize, Modulate, and Scale-up Resveratrol and Resveratrol Dimers Bioproduction in Vitis labrusca L. Cell Suspension f
jan.back@mci.edu
Parameter Screening of PVDF/PVP Multi-Channel Capillary Membranes.
ben.forbes@kcl.ac.uk
A Design of Experiments Approach to Identify Critical Processing Parameters for Manufacture of an Autologous Platelet Ge
yangsw@hfnu.edu.cn
Aspects and Implementation of Pharmaceutical Quality by Design from Conceptual Frameworks to Industrial Applications.
cecilia.brunetti@ipsp.cnr.it
Optimization of a Green Ultrasound-Assisted Extraction of Different Polyphenols from Pistacia lentiscus L. Leaves Using
m.landin@usc.es
Artificial Neural Networks Elucidated the Essential Role of Mineral Nutrients versus Vitamins and Plant Growth Regulator
mwson2020@mtherapharma.com
Design of Experiments-Based Optimization of Flavonoids Extraction from Daphne genkwa Flower Buds and Flavonoids Contents
possidonio@unifesp.br
Dissolution of Silk Fibroin in Mixtures of Ionic Liquids and Dimethyl Sulfoxide: On the Relative Importance of Temperatu
enezami@aeoi.org.ir
History, Phylogeny, Biodiversity, and New Computer-Based Tools for Efficient Micropropagation and Conservation of Pistac
volker.abetz@hereon.de
Experimental Design in Polymer Chemistry-A Guide towards True Optimization of a RAFT Polymerization Using Design of Expe
ygao@hainanu.edu.cn
Extraction, Isolation, Screening, and Preliminary Characterization of Polysaccharides with Anti–Oxidant Activities from
duarte.carvalho@i3bs.uminho.pt
A Design of Experiments (DoE) Approach to Optimize Cryogel Manufacturing for Tissue Engineering Applications.
agne.mazurkeviciute@lsmu.lt
Modeling, the Optimization of the Composition of Emulgels with Ciclopirox Olamine, and Quality Assessment.
jadhavsb@drreddys.com
Analytical Enantio-Separation of Linagliptin in Linagliptin and Metformin HCl Dosage Forms by Applying Two-Level Factori
sonja.stojanov@uns.ac.rs
A Novel Approach for the Estimation of the Efficiency of Demulsification of Water-In-Crude Oil Emulsions.
mariana.p.bezerra@gsk.com
Enhancing Process Control and Quality in Amorphous Solid Dispersions Using In-Line UV-Vis Monitoring of L* as a Real-Tim
steven.short@merck.com
Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors.
hsyang@go.hwh.edu.tw
Biogas Upgrading by Pressure Swing Adsorption with Design of Experiments
dornerm@rki.de
Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A-F Employing Taguchi Design-of-Experiment
amine.kamen@mcgill.ca
Development of Long-Term Stability of Enveloped rVSV Viral Vector Expressing SARS-CoV-2 Antigen Using a DOE-Guided Appro
ahad.mokhtarzadeh@gmail.com
Implementation of a Design of Experiments to Improve Periplasmic Yield of Functional ScFv Antibodies in a Phage Display
Laura.Cervera@uab.cat
Optimization, Production, Purification and Characterization of HIV-1 GAG-Based Virus-like Particles Functionalized with
tiziana.amoriello@crea.gov.it
Optimization of Phenolic Compound Extraction from Brewers’ Spent Grain Using Ultrasound Technologies Coupled with Respon
tanfj@dragon.nchu.edu.tw
Optimization of ultrasonic-assisted enzymatic hydrolysis conditions for the production of antioxidant hydrolysates from