novasign · 289 papers with claims · 165 for outreach · 114 old · 10 reviews
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Bioreactor scale‐down studies of suspended plant cell cultures
Scale‐Up and Scale‐Down Methodologies for Bioreactors
Scale‐Down: Simulating Large‐Scale Cultures in the Laboratory
A Monte‐Carlo approach for the simulation of microbial population dynamics in an heterogeneous scale‐down bioreactor
Two scale‐down tools for the optimization of perfusion bioreactors for the manufacture of biopharmaceuticals
Scale-Down Model Development in ambr systems: An Industrial Perspective.
Scale‐Down Analysis of Fouling in Cell Retention Devices for the Continuous Production of Monoclonal Antibodies
The impact of pH inhomogeneities on CHO cell physiology and fed-batch process performance - two-compartment scale-down m
Computational fluid dynamics simulation improves the design and characterization of a plug‐flow‐type scale‐down reactor
Multivariate Data Analysis Methodology to Solve Data Challenges Related to Scale-Up Model Validation and Missing Data on
Equal mixing time enables scale-down and optimization of a CHO cell culture process using a shaken microbioreactor syste
Scaling strategy for cell and gene therapy bioreactors based on turbulent parameters
Metabolic profile of 1,5‐diaminopentane producing Corynebacterium glutamicum under scale‐down conditions: Blueprint for
Physiological effects of pH gradients on Escherichia coli during plasmid DNA production.
Enhancing the functionality of a microscale bioreactor system as an industrial process development tool for mammalian pe
Power input effects on degeneration in prolonged penicillin chemostat cultures: A systems analysis at flux, residual glu
Coupled metabolic‐hydrodynamic modeling enabling rational scale‐up of industrial bioprocesses
Real‐time dissolved carbon dioxide monitoring I: Application of a novel in situ sensor for CO<sub>2</sub> monitoring and
Development of a shake tube-based scale-down model for perfusion cultures.
A model‐based framework for parallel scale‐down fed‐batch cultivations in mini‐bioreactors for accelerated phenotyping
Microfluidic single‐cell scale‐down bioreactors: A proof‐of‐concept for the growth of <i>Corynebacterium glutamicum</i>
A scaled‐down model for the translation of bacteriophage culture to manufacturing scale
Understanding the effect of high gas entrance velocity on Chinese hamster ovary (CHO) cell culture performance and its i
Physiological Response of <i>Penicillium chrysogenum</i> to Mimicked Local and Global Perturbations of Substrate and Dis
Computational fluid dynamics based digital twins of fixed bed bioreactors validate scaling principles for recombinant ad
A CFD model for predicting protein aggregation in low-pH virial inactivation for mAb production.
Mimicking CHO large‐scale effects in the single multicompartment bioreactor: A new approach to access scale‐up behavior
Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided
Perfusion Process Intensification for Lentivirus Production Using a Novel Scale-Down Model.
An industrial perspective on metabolic responses of <i>Penicillium chrysogenum</i> to periodic dissolved oxygen feast‐fa
Platform development for high‐throughput optimization of perfusion processes: Part I: Implementation of cell bleeds in m
Establishing a scalable perfusion strategy for the manufacture of CAR ‐T cells in stirred‐tank bioreactors using a quali
A practical approach in bioreactor scale‐up and process transfer using a combination of constant <i>P</i>/<i>V</i> and v
High throughput automated microbial bioreactor system used for clone selection and rapid scale‐down process optimization
Optimizing performance of semi-continuous cell culture in an ambr15™ microbioreactor using dynamic flux balance modeling
Characterization of TAP Ambr 250 disposable bioreactors, as a reliable scale-down model for biologics process developmen
Evaluating manufacturing process profile comparability with multivariate equivalence testing: Case study of cell-culture
Identification of upstream culture conditions and harvest time parameters that affect host cell protein clearance
A protocol to transfer a fed-batch platform process into semi-perfusion mode: The benefit of automated small-scale biore
Semi‐continuous scale‐down models for clone and operating parameter screening in perfusion bioreactors
Novel electrodynamic oscillation technique enables enhanced mass transfer and mixing for cultivation in micro‐bioreactor
A novel scale‐down mimic of perfusion cell culture using sedimentation in an automated microbioreactor (SAM)
Model‐based workflow for scale‐up of process strategies developed in miniaturized bioreactor systems
Microbioreactor ( micro‐Matrix ) potential in aerobic and anaerobic conditions with different industrially relevant micr
Scale-down model qualification of ambr® 250 high-throughput mini-bioreactor system for two commercial-scale mAb processe
Development of a small-scale rotary lobe-pump cell culture model for examining cell damage in large-scale N-1 seed perfu
High‐throughput screening of antibody‐expressing CHO clones using an automated shaken deep‐well system
Development of bioreactor scale-down model using orthogonal projections to latent structures method and CO2 supplementat
Computational fluid dynamics analysis of mixing and gas–liquid mass transfer in wave bag bioreactor
Modeling scalability of impurity precipitation in downstream biomanufacturing.
Development of a high-throughput scale-down model in Ambr® 250 HT for plasmid DNA fermentation processes.
Development of a method for reliable power input measurements in conventional and single‐use stirred bioreactors at labo
Editorial: How can we ensure the successful transfer from lab‐ to large‐scale production?
Plug flow versus stirred tank reactor flow characteristics in two‐compartment scale‐down bioreactor: Setup‐specific infl
Euler‐Lagrange computational fluid dynamics for (bio)reactor scale down: An analysis of organism lifelines
Performance loss of <i>Corynebacterium glutamicum</i> cultivations under scale‐down conditions using complex media
Development, characterization, and application of a 2‐Compartment system to investigate the impact of pH inhomogeneities
Microbial population heterogeneity versus bioreactor heterogeneity: Evaluation of Redox Sensor Green as an exogenous met
Scale‐down simulators for mammalian cell culture as tools to access the impact of inhomogeneities occurring in large‐sca
An analysis of organism lifelines in an industrial bioreactor using Lattice‐Boltzmann CFD
A perspective‐driven and technical evaluation of machine learning in bioreactor scale‐up: A case‐study for potential mod
Investigation of cell line specific responses to pH inhomogeneity and consequences for process design
Modelling concentration gradients in fed-batch cultivations of E. coli
Scaling‐down biopharmaceutical production processes via a single multi‐compartment bioreactor (SMCB)
Process adapted calibration improves fluorometric pH sensor precision in sophisticated fermentation processes.
Influence of oxygen concentration on the metabolism of Penicillium chrysogenum
Shake tube perfusion cell cultures are suitable tools for the prediction of limiting substrate, CSPR , bleeding strategy
Insight into the large‐scale upstream fermentation environment using scaled‐down models
Sterol synthesis and cell size distribution under oscillatory growth conditions in <i>Saccharomyces cerevisiae</i> scale
Importance of the cultivation history for the response of Escherichia coli to oscillations in scale-down experiments.
Culture Miniaturization of Lipase Production by Yarrowia lipolytica
Using computational fluid dynamics simulation improves the design and subsequent characterization of a plug-flow type sc
Reconstruction of Industrial Processes for Cultivating CHO Cells in a Scale-Down Bioreactor Model
Novel spiking methods developed for anion exchange chromatography operating in continuous processing
An industrial perspective on in vivo kinetics of central metabolite pools and dynamic flux responses in Penicillium chry
Perfusion-Based Antibody Production in the Ambr® 250 Modular.
Developing an effective scale-down model for a suspension adapted HEK293T-derived lentiviral vector stable producer cell
Intracellular Profiling for Biopharmaceutical Cultivation Processes
Application of flow cytometry analysis to elucidate the impact of scale-down conditions in Escherichia coli cultivations
Application of flow cytometry analysis to elucidate the impact of scale-down conditions in Escherichia coli cultivations
Characterization of bioreactors and scaling down of Escherichia coli culture in a vaccine manufacturing process
Characterization and Scalability Assessment of a Parallel Single-Use Bioreactor System for Mammalian Cell Culture
Identification des critères d’extrapolation du procédé de production de cellulases par Trichoderma reesei en utilisant l
pH fluctuations imperil the robustness of C. glutamicum to short term oxygen limitation.
A robust scale-down model development and process characterization for monoclonal antibody biomanufacturing using multiv
AAV vector production: Troublesome host innate responses in another setting
Multi-parameter process optimization for high yield AAV2 vector production using scale-down multi-parallel bioreactor sy
Predicting the influence of combined oxygen and glucose gradients based on scale-down and modelling approaches for the s
A scale-down model of 4000-L cell culture process for inactivated foot-and-mouth disease vaccine production.
Production Process Development of Pseudorabies Virus Vaccine by Using a Novel Scale-Down Model of a Fixed-Bed Bioreactor
A comprehensive study of glucose and oxygen gradients in a scaled-down model of recombinant HuGM-CSF production in therm
Upstream cell culture process characterization and in-process control strategy development at pandemic speed.
Performing in spite of starvation: How Saccharomyces cerevisiae maintains robust growth when facing famine zones in indu
Chemical and Biological Sensor Capsules for Real-Time Measurement of Cell Properties in Bioreactors
Bioprocess scale‐up/down as integrative enabling technology: from fluid mechanics to systems biology and beyond
Genome reduction improves octanoic acid production in scale down bioreactors
Integrated Robotic Mini Bioreactor Platform for Automated, Parallel Microbial Cultivation With Online Data Handling and
Scaling Up and Scaling Down for Cell Culture Bioreactors
Scale-Down Effect on Hydrodynamics, Mass Transfer, and Bioconversion in a Multiphase Partitioning Bioreactor
Development and Qualification of a Scale-Down Mammalian Cell Culture Model and Application in Design Space Development b
Use of near-infrared spectroscopy (NIRs) in the biopharmaceutical industry for real-time determination of critical proce
Pseudorabies virus production using a serum-free medium in fixed-bed bioreactors with low cell inoculum density.
Establishment and optimization of a high-throughput mimic perfusion model in ambr® 15.
Establishment of a semi-continuous scale-down clone screening model for intensified perfusion culture.
Rapid process development of serum-free pseudorabies virus production with the Quality by Design approach.
Quality by Design characterization of the perfusion culture process for recombinant FVIII.
Modelling of industrial-scale bioreactors using the particle lifeline approach
CFD predictive simulations of miniature bioreactor mixing dynamics coupled with photo-bioreaction kinetics in transition
Power, mixing and flow dynamics of the novel Allegro™ stirred tank reactor
Euler-Lagrange analysis towards representative down-scaling of a 22 m3 aerobic S. cerevisiae fermentation
Flow-informed clustering of bioreactor volumes to build CFD-based compartment models
Computational fluid dynamics simulation of an industrial P. chrysogenum fermentation with a coupled 9-pool metabolic mod
Microfluidic single-cell scale-down systems: introduction, application, and future challenges.
Suspension and flow dynamics of the Allegro™ stirred tank reactor
Unsupervised learning bioreactor regimes
Bioprocess microfluidics: applying microfluidic devices for bioprocessing
Chemical reactor/compounding vessel fingerprinting: Scale-up/down considerations for homogeneous and heterogeneous mixin
Proteomic analysis of micro-scale bioreactors as scale-down model for a mAb producing CHO industrial fed-batch platform.
High-density perfusion cultures of the marine bacterium Rhodovulum sulfidophilum for the biomanufacturing of oligonucleo
An in-silico analysis of hydrodynamics and gas mass transfer characteristics in scale-down models for mammalian cell cul
Development and qualification of a representative scale-down model of automated Ficoll-based processing of a cell-based
Simulating Process Limitations in Microbial Cultivation: A Parallel Two-Compartment Scale-Down Approach
Process design and development of a mammalian cell perfusion culture in shake-tube and benchtop bioreactors.
Development and qualification of 3 L scale-down model for large scale vaccine process on Vero cell culture using microca
Analysis of Tubespins as a suitable scale-down model of bioreactors for high cell density CHO cell culture.
Development of a miniature bioreactor model to study the impact of pH and DOT fluctuations on CHO cell culture performan
The role of Raman spectroscopy in biopharmaceuticals from development to manufacturing
Glucose-Limited Fed-Batch Cultivation Strategy to Mimic Large-Scale Effects in Escherichia coli Linked to Accumulation o
Методические подходы к валидации технологических процессов получения терапевтических рекомбинатных белков на основе конц
Optimization of an Industrial Aerobic Bioreactor Using Combined CFD, Scale-Down, and Experimental Techniques
CFD supported scale up of perfusion bioreactors in biopharma
Scalable CAR-T production in a 2-litre perfusion stirred-tank bioreactor with automated harvesting and scale-down model
Growth and eGFP Production of CHO-K1 Suspension Cells Cultivated From Single Cell to Laboratory Scale
Seed Train Optimization in Microcarrier-Based Cell Culture Post In Situ Cell Detachment through Scale-Down Hybrid Modeli
Monitoring of the Single-Cell Behavior of an Escherichia coli Reporter Strain Producing L-phenylalanine in a Scale-Down
Hybrid Approach for Mixing Time Characterization and Scale-Up in Geometrical Nonsimilar Stirred Vessels Equipped with Ec
Development and application of a cultivation platform for mammalian suspension cell lines with single-cell resolution (M
Microfluidic single-cell scale-down bioreactors: A proof-of-concept for the growth of <i>Corynebacterium glutamicum</i>
Optimal operation of parallel mini-bioreactors in bioprocess development using multi-stage MPC
Automation assisted anaerobic phenotyping for metabolic engineering.
Bovine myoblast cell production in a microcarriers-based system
Morphology-driven downscaling of Streptomyces lividans to micro-cultivation
Engineering of Scale-Down Bioreactor Setup: Deciphering Metabolic Phenotype of Corynebacterium glutamicum under Simulate
Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling
Tilman; Neubauer, Peter; Bournazou
peter.neubauer@tu-berlin.de
Automated Conditional Screening of Escherichia Coli Knockout Mutants in Parallel Adaptive Fed-Batch Cultivations
ViewJochen.Scholz@sartorius.com
Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch
m.micheletti@ucl.ac.uk
Cell clone selection—impact of operation modes and medium exchange strategies on clone ranking
joana.silva.14@ucl.ac.uk
Small-Scale Fluidized Bed Bioreactor for Long-Term Dynamic Culture of 3D Cell Constructs and in vitro Testing.
kino-oka@bio.eng.osaka-u.ac.jp
Development of 10 L mass culture system of human induced pluripotent stem cells with intermittent agitation using plasti
guodongs@njnu.edu.cn
Optimization and Scale-Up of Fermentation Processes Driven by Models
n.krausch@tu-berlin.de
Automated Conditional Screening of Multiple Escherichia coli Strains in Parallel Adaptive Fed-Batch Cultivations
sjung@pbsbiotech.com
Measurement of Oxygen Transfer Rate and Specific Oxygen Uptake Rate of h-iPSC Aggregates in Vertical Wheel Bioreactors t
mkordas@zut.edu.pl
Hydrodynamics and Mass Transfer Analysis in BioFlow® Bioreactor Systems
henk.noorman@dsm.com
Predicting By-Product Gradients of Baker’s Yeast Production at Industrial Scale: A Practical Simulation Approach
steven.minden@ibvt.uni-stuttgart.de
Monitoring Intracellular Metabolite Dynamics in Saccharomyces cerevisiae during Industrially Relevant Famine Stimuli
genzel@mpi-magdeburg.mpg.de
Optimization of YF17D-Vectored Zika Vaccine Production by Employing Small-Molecule Viral Sensitizers to Enhance Yields
Zweigerdt.Robert@mh-hannover.de
Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
z.ali@tees.ac.uk
Microbioreactor for lower cost and faster optimisation of protein production
nmalinov@udel.edu
Pseudo perfusion of Chinese Hamster Ovary (CHO) cells as a reliable platform for data generation to model and guide cont
s.a.wahl@tudelft.nl
Escherichia coli metabolism under short-term repetitive substrate dynamics: adaptation and trade-offs
aburns13@students.kgi.edu
Novel low shear 3D bioreactor for high purity mesenchymal stem cell production
dirk.weuster-botz@tum.de
Scale-down bioreactors-comparative analysis of configurations.
w.olughu@pm.me
Does the BioBLU 0.3f single-use scale to the BioFlo® 320 reuseable bioreactor on a matched volumetric oxygen mass transf
juan-sebastian.reyes@polymtl.ca
Modern Sensor Tools and Techniques for Monitoring, Controlling, and Improving Cell Culture Processes