Evidence For Senolytic Drugs In Age Related Diseas

Skeletal muscle performance and ageing

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

From discoveries in ageing research to therapeutics for healthy ageing

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

Design of a Randomized Placebo-Controlled Trial to Evaluate the Anti-inflammatory and Senolytic Effects of Quercetin in

Cardiomyocytes Cellular Phenotypes After Myocardial Infarction

Metabolism and senescence in the immune microenvironment of osteosarcoma: focus on new therapeutic strategies

Pancreatic β-cell senescence in diabetes: mechanisms, markers and therapies

Cellular Senescence as the Pathogenic Hub of Diabetes-Related Wound Chronicity

Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies

Drugs against metabolic diseases as potential senotherapeutics for aging-related respiratory diseases.

Targeting Inflammation and Immunosenescence to Improve Vaccine Responses in the Elderly

Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair

Cellular senescence is a key mediator of lung aging and susceptibility to infection

COVID-19 Immunobiology: Lessons Learned, New Questions Arise

Senescence, NK cells, and cancer: navigating the crossroads of aging and disease

Cellular senescence in brain aging and cognitive decline

Senolytic and senomorphic secondary metabolites as therapeutic agents in Drosophila melanogaster models of Parkinson’s d

Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic ad

Cellular senescence in cancer: clinical detection and prognostic implications

Oligodendrocyte progenitor cells in Alzheimer’s disease: from physiology to pathology

The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing

12489 Senolytics Dasatinib And Quercetin Alleviate Type 1 Diabetes-Related Cardiac Fibrosis In Male Akita Ins-/+Mice

New Horizons: Novel Approaches to Enhance Healthspan Through Targeting Cellular Senescence and Related Aging Mechanisms.

Age-related Changes in the Adrenal Cortex: Insights and Implications

A phase II randomized double-blind placebo-controlled study of fisetin to improve physical function in frail older breas

Targeting chemoresistant senescent pancreatic cancer cells improves conventional treatment efficacy

Senolytics: Potential for Alleviating Diabetes and Its Complications

A phase II randomized placebo-controlled study of fisetin and exercise to mitigate chemotherapy-related functional decli

Potential Clinical Implications of Senotherapies for Cardiovascular Disease.

Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction

A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers.

Translating the biology of aging into novel therapeutics for Alzheimer disease

7581 Periodic Administration of Quercetin and Dasatinib Alleviates Skeletal Fragility in the INS2AKITA Mouse Model of Ty

CELL SENESCENCE AND SENOLYTIC TREATMENT FOR LOW BACK PAIN

Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Recent advances in the treatment of osteoarthritis

Translating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics.

Aging, Senescence, and Dementia

Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial.

Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?

Identification of Novel Senescent Markers in Small Extracellular Vesicles

Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative St

Hematopoietic Stem Cells and the Immune System in Development and Aging

New Senolysis Approach via Antibody–Drug Conjugate Targeting of the Senescent Cell Marker Apolipoprotein D for Skin Reju

Pro-Osteogenic and Anti-Inflammatory Synergistic Effect of Orthosilicic Acid, Vitamin K2, Curcumin, Polydatin and Querce

Cycloastragenol: A Novel Senolytic Agent That Induces Senescent Cell Apoptosis and Restores Physical Function in TBI-Age

Skin Cancer Microenvironment: What We Can Learn from Skin Aging?

Physiological Approaches Targeting Cellular and Mitochondrial Pathways Underlying Adipose Organ Senescence

Exploring the Communication of the SASP: Dynamic, Interactive, and Adaptive Effects on the Microenvironment

TMT-Based Proteomics Analysis of Senescent Nucleus Pulposus from Patients with Intervertebral Disc Degeneration

High-Tech Methods of Cytokine Imbalance Correction in Intervertebral Disc Degeneration

Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies.

Cells in Atherosclerosis: Focus on Cellular Senescence from Basic Science to Clinical Practice

Cellular Senescence: A Troy Horse in Pulmonary Fibrosis

New Dawn for Atherosclerosis: Vascular Endothelial Cell Senescence and Death

Inflammatory and Metabolic Signaling Interfaces of the Hypertrophic and Senescent Chondrocyte Phenotypes Associated with

Senotherapeutics to Counteract Senescent Cells Are Prominent Topics in the Context of Anti-Ageing Strategies

The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency

The Plastic Interplay between Lung Regeneration Phenomena and Fibrotic Evolution: Current Challenges and Novel Therapeut

Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-Aging Strategies

Mechanochemical Approach to Obtaining a Multicomponent Fisetin Delivery System Improving Its Solubility and Biological A

Spatio-Temporal Characterization of Cellular Senescence Hallmarks in Experimental Ischemic Stroke.

Endothelial Senescence: From Macro- to Micro-Vasculature and Its Implications on Cardiovascular Health

Senescence in Adipose-Derived Stem Cells: Biological Mechanisms and Therapeutic Challenges

The Differential Effect of Senolytics on SASP Cytokine Secretion and Regulation of EMT by CAFs

The Senescent Heart—“Age Doth Wither Its Infinite Variety”

Cellular Senescence and Inflammaging in the Bone: Pathways, Genetics, Anti-Aging Strategies and Interventions.

Targeting Aging Hallmarks with Monoclonal Antibodies: A New Era in Cancer Immunotherapy and Geriatric Medicine.

Targeting Cellular Senescence with Liposome-Encapsulated Fisetin: Evidence of Senomorphic Effect

Functional Features of Senescent Cells and Implications for Therapy.

Effectiveness of PROTAC BET Degraders in Combating Cisplatin Resistance in Head and Neck Cancer Cells.

Addition of Polyphenols to Drugs: The Potential of Controlling “Inflammaging” and Fibrosis in Human Senescent Lung Fibro

Rewinding the Clock: Emerging Pharmacological Strategies for Human Anti-Aging Therapy

Multi-Target Botanical Complex Attenuates Cellular Senescence via Bidirectional P21/P53/SIRT1 Regulation: Dual Model Val

Therapy-Induced Senescence (TIS) and SASP: The p53-Mediated Interplay in Cancer Progression and Treatment.

Vascular Dementia: From Pathophysiology to Therapeutic Frontiers

Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro

Selective Senolysis of 5FU-Induced CRC Senescent Cells by Piceatannol Through Mitochondrial Depolarization and AIF-Depen

Cellular Senescence in Cardiovascular Diseases: From Pathogenesis to Therapeutic Challenges.

Endothelial Senescence and the Chronic Vascular Diseases: Challenges and Therapeutic Opportunities in Atherosclerosis

Reduction in Lens Epithelial Cell Senescence Burden through Dasatinib Plus Quercetin or Rapamycin Alleviates D-Galactose

Investigating the Effects of Chelidonic Acid on Oxidative Stress-Induced Premature Cellular Senescence in Human Skin Fib

Temozolomide, Procarbazine and Nitrosoureas in the Therapy of Malignant Gliomas: Update of Mechanisms, Drug Resistance a

Fisetin as a Senotherapeutic Agent: Biopharmaceutical Properties and Crosstalk between Cell Senescence and Neuroprotecti

Anti-Leukemic Properties of Aplysinopsin Derivative EE-84 Alone and Combined to BH3 Mimetic A-1210477.

Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging

Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence

Quercetin Is An Active Agent in Berries against Neurodegenerative Diseases Progression through Modulation of Nrf2/HO1

Flavonol Technology: From the Compounds' Chemistry to Clinical Research.

Senotherapeutics for Brain Aging Management

Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired S

Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan.

Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury

Cellular Senescence and Iron Dyshomeostasis in Alzheimer’s Disease

Phenotypic Screening in C. elegans as a Tool for the Discovery of New Geroprotective Drugs

Quercetin Intake and Absolute Telomere Length in Patients with Type 2 Diabetes Mellitus: Novel Findings from a Randomize

Senescence of endplate osteoclasts induces sensory innervation and spinal pain

Classic challenges and emerging approaches to medication therapy in older adults.

Editor's evaluation: Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart

Senotherapeutic drugs for human intervertebral disc degeneration and low back pain

CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis.

CLINICAL MANAGEMENT OF THE OLDER ADULT The Clinical Potential of Senolytic Drugs

1 Senescent, dysfunctional human cardiac progenitor cells (CPCs) accumulate in the aged heart and elimination of senesce

Potential Disease-Modifying Treatment Strategies Targeting Senescence in the Setting of Knee Osteoarthritis

Assessing the Effect of PROTAC 753b Senolytic on Intervertebral Disc Aging

Age-Related Alterations in Immune Function and Inflammation: Focus on Ischemic Stroke

Underlying Mechanisms and Treatment of Cellular Senescence-Induced Biological Barrier Interruption and Related Diseases

Aging, Cellular Senescence, and Glaucoma

The Bcl-2/Bcl-xL Inhibitor ABT-263 Attenuates Retinal Degeneration by Selectively Inducing Apoptosis in Senescent Retina

Senolytics and Senostatics: A Two-Pronged Approach to Target Cellular Senescence for Delaying Aging and Age-Related Dise

The Complex Bidirectional Relationship Between Aging and Atherosclerosis: Mechanistic Insights and Translational Opportu

Senescent T Cells in Age-Related Diseases

Targeting Cell Senescence to Improve Cardiac Regeneration

RISING STARS: Targeting premature cellular senescence using senomorphic or senolytic agents to impact diabetes.

The aging endothelium

Advances and challenges in geroscience research: An update

The Aging Kidney and Acute Kidney Injury.

JAK2/STAT3 regulates estrogen-related senescence of bone marrow stem cells

Assessing the Complexities of Utilizing BH3 Mimetics for a Senolytic Strategy in Combination with Ionizing Radiation.

Can senolysis be used to overcome tumor immune evasion?

The Roles of Autophagy and Senescence in the Tumor Cell Response to Radiation.

Kidney Disease as a Driver of Immunosenescence: Mechanisms and Potential Interventions.

From causes of aging to death from COVID-19

Senolytic drugs relieve pain by reducing peripheral nociceptive signaling without modifying joint tissue damage in spont

Targeting anticancer drug-induced senescence in glioblastoma therapy

Senescence and senotherapies in biliary atresia and biliary cirrhosis

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Senescent Cells: Dual Implications on the Retinal Vascular System.

Potential of Plant-Derived Compounds in Preventing and Reversing Organ Fibrosis and the Underlying Mechanisms

Rejuvenation of Mesenchymal Stem Cells to Ameliorate Skeletal Aging

Impaired Remodeling of White Adipose Tissue in Obesity and Aging: From Defective Adipogenesis to Adipose Organ Dysfuncti

Chronological and Biological Aging in Amyotrophic Lateral Sclerosis and the Potential of Senolytic Therapies.

Flavonoids Regulate Redox-Responsive Transcription Factors in Glioblastoma and Microglia

Repurposing Drugs for Senotherapeutic Effect: Potential Senomorphic Effects of Female Synthetic Hormones.

The Role of Senescence in Experimental Periodontitis at the Causal Level: An in Vivo Study.

From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications

Recent Advances in Aging and Immunosenescence: Mechanisms and Therapeutic Strategies.

Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases

Molecular Regulation of SASP in Cellular Senescence: Therapeutic Implications and Translational Challenges.

From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction.

Cellular Models of Aging and Senescence.

Considering Cause and Effect of Immune Cell Aging on Cardiac Repair after Myocardial Infarction

Tert-Butyl Hydroperoxide in Human Adult Mesenchymal Stem Cells Isolated from Dermis: A Stress-Induced Premature Senescen

Multi-Omics Perspectives on Testicular Aging: Unraveling Germline Dysregulation, Niche Dysfunction, and Epigenetic Remod

Nano-Based Theranostic Tools for the Detection and Elimination of Senescent Cells.

Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy

Cellular Senescence in Renal and Urinary Tract Disorders

Insights from In Vivo Studies of Cellular Senescence

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases.

From Lasers to Longevity: Exploring Energy-Based Devices as Senotherapeutic Tools in Dermatology

Senolytic Interventions for Type 2 Diabetes: Current Evidence and Future Directions

Targeting Senescence in Oncology: An Emerging Therapeutic Avenue for Cancer

Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis

Enteric Nervous System Alterations in Inflammatory Bowel Disease: Perspectives and Implications

Inflammation-Accelerated Senescence and the Cardiovascular System: Mechanisms and Perspectives

Ageing, Cellular Senescence and Neurodegenerative Disease

DNA Damage: A Main Determinant of Vascular Aging

Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer

Targeting Aging Pathways in Chronic Obstructive Pulmonary Disease

Epigenetic Basis of Cellular Senescence and Its Implications in Aging

Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases

The Role of Curcumin in the Modulation of Ageing

Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis

Control of Mesenchymal Stromal Cell Senescence by Tryptophan Metabolites

Cellular Senescence in Lung Fibrosis

Natural Polyphenols Targeting Senescence: A Novel Prevention and Therapy Strategy for Cancer

Stiffness and Aging in Cardiovascular Diseases: The Dangerous Relationship between Force and Senescence

Cellular Senescence: Pathogenic Mechanisms in Lung Fibrosis

Skeletal Aging and Osteoporosis: Mechanisms and Therapeutics

Cascade of Inflammatory, Fibrotic Processes, and Stress-Induced Senescence in Chronic GVHD-Related Dry Eye Disease.

Flavonoids in Skin Senescence Prevention and Treatment

Skin Aging, Cellular Senescence and Natural Polyphenols

NGAL as a Potential Target in Tumor Microenvironment

Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake

Senolytic Therapy for Cerebral Ischemia-Reperfusion Injury

Biochemical and Cellular Characterization of New Radio-Resistant Cell Lines Reveals a Role of Natural Flavonoids to Bypa

Inflammation, Oxidative Stress, Senescence in Atherosclerosis: Thioredoxine-1 as an Emerging Therapeutic Target

Flavonoids—Natural Gifts to Promote Health and Longevity

Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs

A Small Molecule That Promotes Cellular Senescence Prevents Fibrogenesis and Tumorigenesis

Cellular Senescence in Immunity against Infections

Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis.

Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge

Structural and Functional Changes in Aging Kidneys

Senolytic Therapy: A Potential Approach for the Elimination of Oncogene-Induced Senescent HPV-Positive Cells

The Effects of Nutrient Signaling Regulators in Combination with Phytocannabinoids on the Senescence-Associated Phenotyp

The Effects of Fisetin on Cyclosporine-Treated Dry Eye Disease in Dogs

Generation of a p21 Reporter Mouse and Its Use to Identify and Eliminate p21high Cells In Vivo

Targeting Multiple Homeostasis-Maintaining Systems by Ionophore Nigericin Is a Novel Approach for Senolysis.

Aging of Liver in Its Different Diseases

Senescence of Tumor Cells in Anticancer Therapy-Beneficial and Detrimental Effects.

Impact of Senolytic Treatment on Gene Expression in Aged Lung

Ketogenic diet induces p53-dependent cellular senescence in multiple organs

Senolytic Treatment for Low Back Pain

106 Senescence as a therapeutic target for myocardial ageing

Senolytics reduce coronavirus-related mortality in old mice

Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human

Current Trends in Anti-Aging Strategies

Senolytics reduce endothelial cell DNA damage and telomere dysfunction in old age

Agents for healthful aging

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span.

Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace

Transplanted senescent renal scattered tubular-like cells induce injury in the mouse kidney.

Cellular senescence mediates doxorubicin chemotherapy-induced vascular endothelial dysfunction: translational evidence o

Single Cell Profiling Reveals Unique Contributions of Senescent Macrophages across Musculoskeletal Tissues in Posttrauma

Cellular senescence in the lung across the age spectrum.

Cellular Senescence and Inter-Organ Communication in Health and Disease.

Recent Advances in Senolysis for Age-Related Diseases.

Cellular Senescence: Aging, Cancer, and Injury

Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer

Clearing Senescent Endothelial Cells with Senolytics Restores Replicative Capacity

GPX4 Over-expression Is Associated with Increased Senescence Burden and Metabolic Dysfunction

The Role Of Senolytics In Reducing Senescence Induced By Cannabinoids And Nicotine In Prenatal Human Lung

Fisetin supplementation targets senescent endothelial cells in old mice and prevents plasma-induced endothelial dysfunct

Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases

The Emerging Role of Senescence in Ocular Disease.

Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence

Network Pharmacology Analysis to Identify Phytochemicals in Traditional Chinese Medicines That May Regulate ACE2 for the

Current Progress in the Rejuvenation of Aging Stem/Progenitor Cells for Improving the Therapeutic Effectiveness of Myoca

Pharmacological Approaches to Decelerate Aging: A Promising Path

One‐Two Punch Therapy for the Treatment of T‐Cell Malignancies Involving p53‐Dependent Cellular Senescence

Biological Activities Underlying the Therapeutic Effect of Quercetin on Inflammatory Bowel Disease

Senotherapy Protects against Cisplatin-Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage

BCL-xL Targeting to Induce Apoptosis and to Eliminate Chemotherapy-Induced Senescent Tumor Cells: From Navitoclax to Pla

Dihydroartemisinin Attenuated Intervertebral Disc Degeneration via Inhibiting PI3K/AKT and NF‐<i>κ</i>B Signaling Pathwa

Therapy-Induced Senescence Drives Bone Loss.

Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence.

Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma.

The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24−/− Progeria Mouse Model

Extracellular Vesicle-Packaged ACSL4 Induces Hepatocyte Senescence to Promote Hepatocellular Carcinoma Progression.

Cortactin Suppresses mTOR-Dependent Senescence in Circulating Tumor Cells.

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

Single-cell Transcriptomic Analysis Identifies Senescent Osteocytes that Trigger Bone Destruction in Breast Cancer Metas

Abstract 2449: FGFR4 inhibitor BLU9931 induces cellular senescence in pancreatic ductal adenocarcinoma cell lines promot

Abstract 901: Elimination of senescent tumor cells by ABT263 interferes with proliferative recovery and provides a two-h

Tales of Cancer-Induced Bone Disease from the Senescent Osteocyte Crypt.

Abstract B022: Targeting senescence cells in cancer and aging by conditionally active biologic therapeutics

Harnessing senolytics and PARP inhibition to expand the antitumor activity of CDK4/6 inhibitors in prostate cancer.

Abstract 425: Characterization of TKI-induced drug-tolerant persister cells from a patient-derived cell line

Abstract 5025: Single cell RNA sequencing reveals degenerative mechanisms in osteoblastic osteosarcoma and targetability

Abstract 2958: Melphalan-treated multiple myeloma cells exhibit a senescent-like dormancy phenotype

Abstract 5941: Small molecule NSC59984 synergizes with PARP inhibitors in BRCA1 wild type ovarian cancer

Abstract 2977: Novel HSP90 inhibitors with senolytic activity for a targeted therapy in a hormone-induced breast cancer

Abstract 4795: Conditionally active biologics eliminates senescence cells in cancer and aging

Abstract 4796: Chemotherapy induced senescence drives peripheral neuropathy

Abstract 5221: The first-in-class ERK inhibitor ulixertinib (BVD-523) shows activity in MAPK-driven pediatric low-grade

Abstract CT095: Update: a phase 1/2, open-label study to assess safety, tolerability, biodistribution, radiation dosimet

Abstract 519: CDK4/6 inhibitors and endocrine therapies induce senescence with drug- and cell line-specific vulnerabilit

Abstract PR001: DNA damage-induced senescence as a driver of glioblastoma recurrence

Abstract SoA2-02: Implications of therapy induced senescence in breast cancer

Abstract A028: Dissecting the role of cellular senescence in prostate cancer initiation and immune suppression

Abstract 85: Senescent cells promote breast cancer tumorigenesis

Abstract 299: Characterization of a senescence phenotype induced by advanced glycation end products in prostate cancer

Abstract 2962: Chemotherapy induced senescence drives peripheral neuropathy

Abstract 296: Identification of novel senolytic targets and development of conditionally active biologic-based-drug conj

Targeting Senescence for Next-Generation Cancer Treatments

Abstract A043: Senescent CAFs modulate tumor immunity and promote breast cancer progression

Abstract 4726: ETC-501, a novel brain penetrant MNK kinase inhibitor, potentiates TMZ-induced senescence and sensitizes

Abstract Th0030: Impact of Atherosclerosis-Induced Cellular Senescence on Vascular Cognitive Impairment and Dementia

Abstract CT238: Treatment of frailty with fisetin (TROFFi) in postmenopausal breast cancer survivors: A phase II randomi

Adapted to Survive: Targeting Cancer Cells with BH3 Mimetics

Senolytics Cocktail Dasatinib and Quercetin Alleviate Human Umbilical Vein Endothelial Cell Senescence via the TRAF6-MAP

P21-positive senescent stromal cells promote prostate cancer immune suppression and progression that can be reversed by

Abstract 2969: Targeting novel senescence markers by conditionally active biologics eliminates senescence-associated sec

Abstract 13736: Elimination of Senescent Cells Targeting Senescence Associated Glycoprotein (sagp) Improved the Atherosc

Abstract 100: Omics Strategies To Identify Senescent Cells Mediating Extracellular Matrix Remodeling During Vascular Dis

Decoding senescent drivers in Alzheimer&#x27;s disease: From bench to bedside.

p53 regulated senescence mechanism and role of its modulators in age-related disorders.

The aging interactome: From cellular dysregulation to therapeutic frontiers in age-related diseases.

Targeting senescent HDF with the USP7 inhibitor P5091 to enhance DFU wound healing through the p53 pathway.

Senolytic therapeutics: An emerging treatment modality for osteoarthritis.

Inhibition of matrix metalloproteinase expression by selective clearing of senescent dermal fibroblasts attenuates ultra

Pursuing healthy aging and longevity through natural product and stem cell-driven rejuvenation.

Frentizole derivatives with mTOR inhibiting and senomorphic properties.

Immunosenescence and macrophages: from basics to therapeutics.

Androgen-deprivation induced senescence in prostate cancer cells is permissive for the development of castration-resista

Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.

Decoding craniopharyngioma: From mechanisms to therapy.

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.

Role of astrocyte senescence regulated by the non- canonical autophagy in the neuroinflammation associated to cerebral m

Implication of cellular senescence in the progression of chronic kidney disease and the treatment potencies.

Cellular senescence in bone.

The anti-aging drug Senolytics alleviates vascular endothelial cell senescence by antagonizing the JPX-BRD4-p65 complex.

3-N-Butylphthalide alleviate Aβ-induced cellular senescence through the CDK2-pRB1-Caspase3 axis.

Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer.

Senotherapy: A New Horizon for COPD Therapy.

Targeting senescent cells improves functional recovery after spinal cord injury

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Park

Early Vascular Ageing and Cellular Senescence in Chronic Kidney Disease

Human trials exploring anti-aging medicines.

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in i

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy.

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.

Cellular Senescence: A Translational Perspective

G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence

Cellular senescence in asthma: from pathogenesis to therapeutic challenges.

Reshaping of the tumor microenvironment by cellular senescence: An opportunity for senotherapies.

Epigenetic and senescence markers indicate an accelerated ageing-like state in women with preeclamptic pregnancies.

The role of the senescence-associated secretory phenotype in cardiovascular disease among the elderly.

Natural senotherapeutics in respiratory health: Addressing cellular senescence, inflammaging, and immunosenescence in th

Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer c

Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center,

Identification of miR-106b-5p as a senolytic miRNA.

Inhibitor PF-04691502 works as a senolytic to regulate cellular senescence.

Mechanisms of RPE senescence and potential role of αB crystallin peptide as a senolytic agent in experimental AMD.

Procyanidin C1 from hawthorn modulates metabolic-inflammatory axis to combat vascular senescence in atherosclerosis.

Systems-level modelling of DNA damage, senescence, and stem cell dynamics in ageing.

Navitoclax safety, tolerability, and effect on biomarkers of senescence and neurodegeneration in aged nonhuman primates

Sphingomyelin nanosystems decorated with TSP-1 derived peptide targeting senescent cells.

Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging.

Senolytics and Senomorphics: natural and synthetic therapeutics in the treatment of aging and chronic diseases.

Unknown fates of (brain) oxidation or UFO: Close encounters with neuronal senescence.

Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications.

A senescence-responsive nanodrug amplifies radiotherapy efficacy.

Evaluating causality of cellular senescence in non-alcoholic fatty liver disease

Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases

Cellular senescence in liver diseases: From molecular drivers to therapeutic targeting.

Quantitative PET tracking of intra-articularly administered 89Zr-peptide-decorated nanoemulsions.

Regulation of intestinal senescence during cholestatic liver disease modulates barrier function and liver disease progre

Geroscience-Centric Perspective for Geriatric Psychiatry: Integrating Aging Biology With Geriatric Mental Health Researc

Sex, ancestry, senescence, and aging (SAnSA) are stark drivers of nontuberculous mycobacterial pulmonary disease.

Molecular Mechanisms of Cellular Senescence in Neurodegenerative Diseases.

Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions.

Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging.

Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.

Normothermic liver machine perfusion as a dynamic platform for regenerative purposes: What does the future have in store

A geroscience motivated approach to treat Alzheimer&#x27;s disease: Senolytics move to clinical trials.

Emerging senolytic agents derived from natural products

Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical prac

Activatable senoprobes and senolytics: Novel strategies to detect and target senescent cells.

The senolytic agent ABT263 ameliorates osteoporosis caused by active vitamin D insufficiency through selective clearance

Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degenerat

A guide to senolytic intervention in neurodegenerative disease.

Targeting senescent chondrocytes in osteoarthritis: artificial intelligence powered target identification and hypothesis

Quercetin induces senolysis of doxorubicin-induced senescent fibroblasts by reducing autophagy, preventing their pro-tum

Senolytic targets and new strategies for clearing senescent cells.

Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids.

Reducing Senescent Cell Burden in Aging and Disease.

Cellular Senescence: The Sought or the Unwanted?

Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases.

Mitochondrial dysfunction and cell senescence: deciphering a complex relationship.

Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities

Cellular senescence and the tumour microenvironment

Targeting senescence as an anticancer therapy.

Senolytic Therapy Enabled by Senescent Cell-Sensitive Biomimetic Melanin Nano-Senolytics.

Ligustilide, A Novel Senolytic Compound Isolated from the Roots of Angelica Acutiloba

In Situ Remodeling of Efferocytosis via Lesion‐Localized Microspheres to Reverse Cartilage Senescence

Bioinformatics procedure for investigating senolytic (anti-aging) agents: A digital signal processing technique.

Age‐associated Senescent – T Cell Signaling Promotes Type 3 Immunity that Inhibits the Biomaterial Regenerative Response

Radiotherapy-Induced Astrocyte Senescence Promotes an Immunosuppressive Microenvironment in Glioblastoma to Facilitate T

Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer&#x27;s disease: Evidence from cl

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Endothelial cellular senescence and tau accumulation: An interplay full of opportunities?

CAR T cells: Building on the CD19 paradigm

Inflammasome activation and metabolic remodelling in p16‐positive aging cells aggravates high‐fat diet‐induced lung fibr

New Horizons in Myotonic Dystrophy Type 1: Cellular Senescence as a Therapeutic Target.

Strategies to Reduce the On‐Target Platelet Toxicity of Bcl‐xL Inhibitors: PROTACs, SNIPERs and Prodrug‐Based Approaches

Senescence Signature in Skin Biopsies From Systemic Sclerosis Patients Treated With Senolytic Therapy: Potential Predict

Targeting senescence-associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes

Dissecting Spatiotemporal Heterogeneity of Senescence Markers p16/p21 Across Tissues During Type 2 Diabetes Progression

Indication of Activated Senescence Pathways in the Temporal Arteries of Patients With Giant Cell Arteritis

Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues.

Honokiol‐loaded nanomicelles reprogram senescence and immune evasion in hepatocellular carcinoma via SIRT3 ‐mediated mit

Emerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation

Tofacitinib treatment of rheumatoid arthritis increases senescent T cell frequency in patients and limits T cell functio

The impact of senescence on muscle wasting in chronic kidney disease.

Targeting senescent cholangiocytes and activated fibroblasts with B‐cell lymphoma‐extra large inhibitors ameliorates fib

Bone Aging, Cellular Senescence, and Osteoporosis.

Roles of extracellular vesicles in the aging microenvironment and age‐related diseases

Pharmacologic Interventions for Fracture Risk Reduction in the Oldest Old: What Is the Evidence?

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy‐Related Bone Loss

Screening of Natural Products for Senolytic or Senostatic Activities on Human Senescent Cells (SenoNPs)

Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells

Journal of Bone and Mineral Research: Volume 34, Number 11, November 2019

Clearance of Senescent Cells From Injured Muscle Abrogates Heterotopic Ossification in Mouse Models of Fibrodysplasia Os

The dual role of cellular senescence in human tumor progression and therapy.

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young

Cellular senescence in cancer: molecular mechanisms and therapeutic targets.

Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative bi

Therapeutic potential of nicotinamide and ABT263 in alcohol‐associated liver disease through targeting cellular senescen

Emerging use of senolytics and senomorphics against aging and chronic diseases.

Quercetin as a cancer chemopreventive or chemotherapeutic agent: Where we stand

Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities.

A Reporter Platform to Study Therapy‐Induced Senescence in Live Cancer Cells

Celastrol Targets Hsc70-Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis.

Fisetin Clears Senescent Cells Through the Pi3k-Akt-Bcl-2/Bcl-xl Pathway to Alleviate Diabetic Aortic Aging.

Selective kidney targeting increases the efficacy of mesenchymal stromal/stem cells for alleviation of murine stenotic-k

Obesity, Senescence, and Senolytics.

Senescence in the pathogenesis of age-related macular degeneration.

Anthracycline-induced cardiotoxicity and cell senescence: new therapeutic option?

Discovery of Senolytics and the Pathway to Early Phase Clinical Trials

Quercetin influences intestinal dysbacteriosis and delays alveolar epithelial cell senescence by regulating PTEN/PI3K/AK

Senotherapy: growing old and staying young?

Removing therapy-induced senescent cancer cells targets and potentiates the response of pancreatic cancer cells toward P

Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and ind

Hypertension and cellular senescence.

The potential of flavonoids to mitigate cellular senescence in cardiovascular disease.

Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary b

Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?

Mitochondria-targeted senotherapeutic interventions

3D models to study therapy-induced senescence: where do we stand now?

Identification of resibufogenin, a component of toad venom, as a novel senolytic compound in vitro and for potential ski

Elimination of p19 ARF ‐expressing cells protects against pulmonary emphysema in mice

Tau protein aggregation is associated with cellular senescence in the brain.

DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age

Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic

Oxidation resistance 1 is a novel senolytic target.

Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidativ

Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity

Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2^nd Scripps Symposium on the

Senescent cells: A new Achilles&#x27; heel to exploit for cancer medicine?

Aged‐senescent cells contribute to impaired heart regeneration

Senolytics alleviate the degenerative disorders of temporomandibular joint in old age

Measuring biological aging in humans: A quest

Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflam

Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in ol

Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicit

Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension

NAD metabolism: Role in senescence regulation and aging

Transplanting cells from old but not young donors causes physical dysfunction in older recipients

Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal.

A p21‐GFP zebrafish model of senescence for rapid testing of senolytics in vivo

Cellular senescence as a potential mediator of COVID‐19 severity in the elderly

Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

Strategies for senolytic drug discovery

Protein phosphatase 2A activators reverse age‐related behavioral changes by targeting neural cell senescence

Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐indu

Depletion of preexisting B‐cell lymphoma 2‐expressing senescent cells before vaccination impacts antigen‐specific antitu

Senescent cells at the crossroads of aging, disease, and tissue homeostasis.

Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging

Effect of peripheral cellular senescence on brain aging and cognitive decline.

Senolytic treatment alleviates doxorubicin-induced chemobrain.

Targeting the redox system for cardiovascular regeneration in aging

Clinical validation of C12FDG as a marker associated with senescence and osteoarthritic phenotypes

A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

Late Life Supplementation of 25‐Hydroxycholesterol Reduces Aortic Stiffness and Cellular Senescence in Mice

A novel senolytic drug for pulmonary fibrosis: BTSA1 targets apoptosis of senescent myofibroblasts by activating BAX.

Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensi

Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence

Microphysiological systems for human aging research

Targeting IGF1-Induced Cellular Senescence to Rejuvenate Hair Follicle Aging.

Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging.

Restoration of hair follicle inductive properties by depletion of senescent cells

Asparaginase and Autophagy Inhibitors Effectively Remove Senescent Cells by Synergistically Limiting Asparagine Supply.

Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro-Inflammatory Phenotype of Senescent Cells.

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Senescent Microglia Mediate Neuroinflammation‐Induced Cognitive Dysfunction by Selective Elimination of Excitatory Synap

Novel therapeutic approaches to target neurodegeneration

Cellular senescence contributes to spontaneous repair of the rat meniscus.

Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung disea

Discovery, development, and future application of senolytics: theories and predictions

Inflammation, ageing and diseases of the lung: Potential therapeutic strategies from shared biological pathways

Targeting senescence to prevent diabetic kidney disease: Exploring molecular mechanisms and potential therapeutic target

Cellular senescence in giant cell arteritis and polymyalgia rheumatica: From mechanisms to therapeutic opportunities.

The potential skin‐lightening candidate, senolytic drug ABT263, for photoageing pigmentation

MicroRNA‐guided drug discovery for mitigating persistent pulmonary complications in critical COVID‐19 survivors: A longi

Effects of senescence on the tumour microenvironment and response to therapy

Depletion of SASP senescent cardiomyocytes with senolytic drugs confers therapeutic effects in doxorubicin-related cardi

Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control.

The role of cellular senescence and SASP in tumour microenvironment.

Transcriptomic signatures and network-based methods uncover new senescent cell anti-apoptotic pathways and senolytics.

Cellular senescence as a source of SARS‐CoV‐2 quasispecies

Targeting cellular senescence: A promising approach in respiratory diseases.

Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era.

Senescent T cells: Beneficial and detrimental roles

Senolytic chimeric antigen receptor (CAR) T cell: driving the immune system to fight cell senescence

The Clinical Potential of Senolytic Drugs.

From Neuron-Centric to Glia-Centric: How Aging Glial Networks Drive Neurodegenerative Disease.

Therapeutic opportunities for senolysis in cardiovascular disease

Cellular senescence in the pathogenesis of ovarian dysfunction

Cellular senescence: beneficial, harmful, and highly complex

Cellular Senescence, Inflammaging and Cardiovascular Disease

FOXO4 peptide targets myofibroblast ameliorates bleomycin‐induced pulmonary fibrosis in mice through ECM‐receptor intera

Looking for the philosopher&#x27;s stone: Emerging approaches to target the hallmarks of aging in the skin

Cell senescence in neuropathology: A focus on neurodegeneration and tumours.

Senotherapeutics for metabolic disease and diabetic complications

High-dimensionality Data Analysis of Pharmacological Systems Associated with Complex Diseases

Senolytic drugs: from discovery to translation.

Dasatinib and Quercetin Mitigate Age-Related Alveolar Bone Inflammaging and Neutrophil Infiltration.

Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies.

Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair

Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration.

Myofibroblast fate plasticity in tissue repair and fibrosis: Deactivation, apoptosis, senescence and reprogramming.

Signals of stress

Abstract 331: Clearance Of Senescent Cells Reduces Osteogenic And Fibrogenic Signaling In Fibrocalcific Aortic Valve Ste

Research Progress of Senolytic Drugs in the Treatment of Orthopedic Diseases.

Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease

Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression

Abstract P162: Senolytic Treatment Attenuates Palmitic Acid-Induced Microglial Activation: Therapeutic Implications for

Renovascular Disease Induces Senescence in Renal Scattered Tubular-Like Cells and Impairs Their reparative Potency.

Endothelial Senescence: A New Age in Pulmonary Hypertension

Abstract WP224: Pharmacological Clearance Of Senescent Cells Prevents Intracranial Aneurysm Rupture

Abstract 14285: Sodium Glucose Co-Transporter 2 Inhibition Eliminates Senescent Cells Through Downregulation of PD-L1 an

Abstract 4364300: The Senolytic Navitoclax (ABT263) Reduces Coronary Atherosclerosis and Upregulates Plaque Stability in

Hyperoxia-induced Cellular Senescence in Fetal Airway Smooth Muscle Cells.

Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration

Evidence That SARS-CoV-2 Induces Lung Cell Senescence: Potential Impact on COVID-19 Lung Disease

Dasatinib Plus Quercetin Alleviates Choroid Neovascularization by Reducing the Cellular Senescence Burden in the RPE–Cho

Old Cells in Young Airway Smooth Muscle: Does Neonatal Senescence Cause Lifelong Airway Obstruction?

Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases.

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress.

The Achilles’ heel of cancer survivors: fundamentals of accelerated cellular senescence

Biological aging processes underlying cognitive decline and neurodegenerative disease

Strategies targeting cellular senescence

DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice

Drinking from the fountain of youth for mTOR-related epilepsy

Ginsenosides C-Mc1 and C-O Unique to Wild Ginseng: Novel Senotherapeutic Agents to Regulate Cellular Senescence

Poster 125: Determining Biological Age and Prolonging the Healthspan by Targeting Senescence

Advancements in therapeutic drugs targeting of senescence

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo.

Acute Myeloid Leukemia Induces an Increased Senescent Phenotype in the Large Intestine Which Protects Barrier Function a

Therapy Induced Senescence Is Associated with a Myeloid Gene Signature in Multiple Myeloma Plasma Cells

B-Precursor Acute Lymphoblastic Leukaemia Causes Paracrine Senescence in Mesenchymal Stromal Cells to Subvert the Treatm

Targeting BRD4 to reshape the inflammatory microenvironment of senescent bone marrow mesenchymal stem cells for improved

Targeting BCL-XL and BCL-2 By Protac 753B Effectively Eliminates AML Cells and Enhances Efficacy of Chemotherapy By Targ

Remission instead of eradication? MEK inhibition in primary refractory childhood LCH

Therapy-induced senescence reprograms non-M3 AML into a drug-exploitable APL-like state

Long-Term Clearance of Senescent Cells Prevents the Hematopoietic Stem Cell Aging in Naturally Aged Mice

Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

SARS-CoV-2-induced senescence as a potential therapeutic target

Late Breaking Abstract - Evaluating the feasibility, safety, and efficacy of senolytics in idiopathic pulmonary fibrosis

Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis

Lung regeneration: implications of the diseased niche and ageing

The tyrosine kinase inhibitor Dasatinib reduces cardiac steatosis and fibrosis in obese, type 2 diabetic mice

Shared mechanisms of multimorbidity in COPD, atherosclerosis and type-2 diabetes: the neutrophil as a potential inflamma

Skin senescence: mechanisms and impact on whole-body aging

The use of geroprotectors to prevent multimorbidity: opportunities and challenges.

Senotherapy for chronic lung disease.

Development of new non-viral systems for genetic modification of senescent cells

Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model.

Senescent brain cell types in Alzheimer&#x27;s disease: Pathological mechanisms and therapeutic opportunities.

Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders

Therapy-induced senescence through the redox lens.

Evaluation of exploratory fluid biomarkers from a phase 1 senolytic trial in mild Alzheimer&#x27;s disease.

Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice

Senescence-mediated anticancer effects of quercetin.

New frontier for epilepsy treatment through targeting cellular senescence.

Biological functions of therapy-induced senescence in cancer.

Time for the systems-level integration of aging: Resilience enhancing strategies to prevent Alzheimer’s disease

Morusin targets DNA methyltransferase 1 to trigger senescence and sensitizes colorectal cancer to senolytic therapy.

Senescent cell clearance by the immune system: Emerging therapeutic opportunities.

MiR-34b promotes oxidative stress and induces cellular senescence through TWIST1 in human cervical cancer.

Targeting senescent cells to reshape the tumor microenvironment and improve anticancer efficacy.

The redox-senescence axis and its therapeutic targeting.

Senotherapeutics: Targeting senescence in idiopathic pulmonary fibrosis.

Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and F2 offspring via dif

Peptide-Amphiphilic Nanoassemblies as a Responsive Senolytic Navigator for Targeted Removal of Senescent Cardiomyocytes

Nanodevice-Mediated Immune Cell Recruitment: Targeting Senescent Cells via MMP-3-Responsive CXCL12-Coated Nanoparticles.

Suppression of autophagy induces senescence in the heart.

Prospective Selective Mechanism of Emerging Senolytic Agents Derived from Flavonoids.

Design and Synthesis of Senescence-Targeted Prodrugs with Senomorphic and Senolytic Properties To Mitigate Chemotherapy-

Targeted Supramolecular Senolytics by Enzyme-Responsive Disassembly and Intracellular Polymerization.

Design of a Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated El

Disrupting the Senescence-Associated Secretory Phenotype-M1Macrophage Feedback Loop in Synovitis Using Dual Nano-Switche

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regener

Bone: Targeting old cells to protect old bones

Targeting cellular senescence prevents age-related bone loss in mice.

Senotherapeutics for healthy ageing

Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics

Mapping the Progression of Therapy-Induced Senescence to Therapy Tolerance: An Evolutionarily Conserved Mechanism for Op

Senescence as a therapeutically relevant response to CDK4/6 inhibitors

Regulation of ribosomal gene expression and senescence by a PML-mTOR-RONIN nuclear complex in triple-negative breast can

Cellular senescence in neuroblastoma

BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast ca

Apoptotic priming in senescence predicts specific senolysis by quantitative analysis of mitochondrial dependencies.

Promoting healthy cardiovascular aging: emerging topics

Interconnections between Inflammageing and Immunosenescence During Ageing

The Role of Nutraceuticals and Functional Foods in Mitigating Cellular Senescence and Its Related Aspects: A Key Strateg

Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease

The motor neuron disease mouse model hSOD1-G93A presents a non-canonical profile of senescence biomarkers in the spinal

Hedysarum multijugum Maxim treats ulcerative colitis through the PI3K-AKT and TNF signaling pathway according to network

Senolytic therapy to modulate the progression of Alzheimer&#x27;s Disease (SToMP-AD) - Outcomes from the first clinical

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer

Cellular Senescence and Senescence-Associated Secretory Phenotype Drive Multipotent Cardiac Stem/Progenitor Cell Dysfunc

Single-cell profiling of skeletal muscle reveals a novel senolytic target: CRYAB

The Cancer Senescopedia – Delineation of Cancer Cell Senescence

Targeted senolytic prodrug is well tolerated and results in amelioration of frailty, muscle regeneration and cognitive f

­A Transient Wave of Cellular Senescence is Required for Myofiber Growth and Myonuclear Accretion Following Injury

Evaluation of Exploratory Fluid Biomarker Results from a Phase 1 Senolytic Trial in Mild Alzheimer’s Disease

The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date

Geroprotective technologies in the prevention and modifying treatment of age-associated retinal diseases

296-LB: Loss of SERCA2 Induces Mitochondrial Dysfunction, Increases ß-Cell Senescence, and Accelerates Type 1 Diabetes D

Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Funct

Novel therapeutic approaches to target neurodegeneration

Cellular Senescence and Senolytic Agents: Recent Updates on Their Role and Applications.

Boosting NAD+ for Anti-Aging: Mechanisms, Interventions, and Opportunities

Targeting our aging cells to treat metabolic disease

Piperine: An Anticancer and Senostatic Drug

Senolytic Drugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Clinical Trial

Senolytics as drugs or fashionable dietary supplements

Cellular aging and immunity

Mid-life: a critical window for intervention during aging

Aging, Cellular Senescence and Diabetes Mellitus: Clinicopathological Correlates, Trends and Targets

- **DOI:** 10.32948/ajo.2024.12.25 - **Authors:** Q. Ain - **Year:** 2024 - **Journal:** Asia-Pacific Journal of Oncolog

Exploiting senescence as a therapeutic target in osteoarthritis

Senescence-Inflammatory Regulation of Reparative Cellular Reprogramming in Aging and Cancer

An Appraisal on the Value of Using Nutraceutical Based Senolytics and Senostatics in Aging

Src Tyrosine Kinase Inhibitors: New Perspectives on Their Immune, Antiviral, and Senotherapeutic Potential

Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis

Immunomodulatory Activity of Tyrosine Kinase Inhibitors to Elicit Cytotoxicity Against Cancer and Viral Infection

Application of Quercetin in the Treatment of Gastrointestinal Cancers

Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines

Revisiting the neuroinflammation hypothesis in Alzheimer’s disease: a focus on the druggability of current targets

Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections?

Exploring the perspectives of pharmaceutical experts and healthcare practitioners on senolytic drugs for vascular aging-

Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis

Patho-Physiology of Aging and Immune-Senescence: Possible Correlates With Comorbidity and Mortality in Middle-Aged and O

Immune Senescence, Immunosenescence and Aging

Network Topology of Biological Aging and Geroscience-Guided Approaches to COVID-19

Role of Mitochondria in Retinal Pigment Epithelial Aging and Degeneration

Aging and oral squamous cell carcinoma development: the role of cellular senescence

Geroscience and pathology: a new frontier in understanding age-related diseases

Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome

Phytochemicals from Indian Ethnomedicines: Promising Prospects for the Management of Oxidative Stress and Cancer

Nephroprotective Effects of Synthetic Flavonoid Hidrosmin in Experimental Diabetic Nephropathy

Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease

Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases

A Fisetin Delivery System for Neuroprotection: A Co-Amorphous Dispersion Prepared in Supercritical Carbon Dioxide

Effects of Fisetin Treatment on Cellular Senescence of Various Tissues and Organs of Old Sheep

Vutiglabridin Alleviates Cellular Senescence with Metabolic Regulation and Circadian Clock in Human Dermal Fibroblasts

Cigarette Smoke-Induced Respiratory Response: Insights into Cellular Processes and Biomarkers

Red Ginseng Attenuates the Hepatic Cellular Senescence in Aged Mice

Translating Senotherapeutic Interventions into the Clinic with Emerging Proteomic Technologies.

Mechanisms of Senescence and Anti-Senescence Strategies in the Skin

Targeting Aging and Diseases Associated with Ferroptosis and Senescence Through Modulation of Iron, Oxidative Stress and

Iron Metabolism in Cancer and Senescence: A Cellular Perspective

Oxidative Stress-Driven Cellular Senescence: Mechanistic Crosstalk and Therapeutic Horizons

Tissue-Specific Landscape of Metabolic Dysregulation during Ageing

Aging and Mesenchymal Stem Cells: Basic Concepts, Challenges and Strategies.

p19Arf Exacerbates Cigarette Smoke-Induced Pulmonary Dysfunction

Novel Targets and Therapeutic Strategies for Promoting Organ Repair and Regeneration

Therapeutic Potential of a Senolytic Approach in a Murine Model of Chronic GVHD

New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular Diseases.

Role of Senescent Cells in Cutaneous Wound Healing

Selective Targeting of Senescent FHs74Int Cells by Human Breast Milk Free Fatty Acids.

The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Disease

Targeting of BCL-2 Family Members during Anticancer Treatment: A Necessary Compromise between Individual Cell and Ecosys

Counteracting Immunosenescence-Which Therapeutic Strategies Are Promising?

Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opport

The Role of Autophagy in Osteoarthritic Cartilage

Novel Nutraceutical Compounds in Alzheimer Prevention

Cell Senescence in Heterotopic Ossification.

Accumulation of CD28null Senescent T-Cells Is Associated with Poorer Outcomes in COVID19 Patients

Inflammaging and Senescence-Driven Extracellular Matrix Remodeling in Age-Associated Cardiovascular Disease.

The Role of Senolytics in Osteoporosis

Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration

Cellular Senescence in Liver Cancer: How Dying Cells Become “Zombie” Enemies

Therapeutic Antiaging Strategies

The Combination of Radiation with PARP Inhibition Enhances Senescence and Sensitivity to the Senolytic, Navitoclax, in T

Non-Healing Perianal Fistulas: A Clinical Model of Tissue Senescence Impairing Both Tissue Fibrosis and Regenerative Pot

Anti-Tumorigenic Effect of a Novel Derivative of 2-Hydroxyoleic Acid and the Endocannabinoid Anandamide on Neuroblastoma

Rosmarinic Acid Reduces Microglia Senescence: A Novel Therapeutic Approach for the Management of Neuropathic Pain Sympto

Suppressing the Aging Phenotype of Mesenchymal Stromal Cells: Are We Ready for Clinical Translation?

Senescent Macrophages Release Inflammatory Cytokines and RNA-Loaded Extracellular Vesicles to Circumvent Fibroblast Sene

Understanding the Complex Dynamics of Immunosenescence in Multiple Sclerosis: From Pathogenesis to Treatment

Role of Cellular Senescence in Parkinson’s Disease: Potential for Disease-Modification Through Senotherapy

Cellular Senescence: The Driving Force of Musculoskeletal Diseases.

Targeting Cellular Senescence: Pathophysiology in Multisystem Age-Related Diseases.

Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function

Cellular Senescence: Mechanisms and Therapeutic Potential

The Premature Senescence in Breast Cancer Treatment Strategy.

The Role of Cellular Senescence and SASP in the Pathogenesis of Atherosclerosis and the Therapeutic Potential of Senolyt

Mechanistic Links Between the Gut Microbiome and Longevity Therapeutics

Can Blood-Circulating Factors Unveil and Delay Your Biological Aging?

Biological Aspects of Inflamm-Aging in Childhood Cancer Survivors

Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy

Senescence and Cancer: Role of Nitric Oxide (NO) in SASP

Senolytics for Cancer Therapy: Is All that Glitters Really Gold?

Molecular Mechanisms of Senescence and Implications for the Treatment of Myeloid Malignancies.

Targeting c-IAP1, c-IAP2, and Bcl-2 Eliminates Senescent Glioblastoma Cells Following Temozolomide Treatment

Senolysis-Based Elimination of Chemotherapy-Induced Senescent Breast Cancer Cells by Quercetin Derivative with Blocked H

Senescence in HBV-, HCV- and NAFLD- Mediated Hepatocellular Carcinoma and Senotherapeutics: Current Evidence and Future

Taking Advantage of the Senescence-Promoting Effect of Olaparib after X-ray and Proton Irradiation Using the Senolytic D

Implications of Senescent T Cells for Cancer Immunotherapy

The Cross Talk between Cellular Senescence and Melanoma: From Molecular Pathogenesis to Target Therapies

Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis In

Senolytic Flavonoids Enhance Type-I and Type-II Cell Death in Human Radioresistant Colon Cancer Cells through AMPK/MAPK

Mutation Status and Glucose Availability Affect the Response to Mitochondria-Targeted Quercetin Derivative in Breast Can

Senescent Cells in Cancer: Wanted or Unwanted Citizens.

The Impact of Senescence-Associated Secretory Phenotype (SASP) on Head and Neck Cancers: From Biology to Therapy.

The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets

Aging of the Immune System: Focus on Natural Killer Cells Phenotype and Functions

EA.hy926 Cells and HUVECs Share Similar Senescence Phenotypes but Respond Differently to the Senolytic Drug ABT-263

The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis.

o-Vanillin Modulates Cell Phenotype and Extracellular Vesicles of Human Mesenchymal Stem Cells and Intervertebral Disc C

Abrogation of Cellular Senescence Induced by Temozolomide in Glioblastoma Cells: Search for Senolytics

Senotherapeutics in Cancer and HIV.

Role of Senescence and Aging in SARS-CoV-2 Infection and COVID-19 Disease

Therapeutic Perspectives for Inflammation and Senescence in Osteoarthritis Using Mesenchymal Stem Cells, Mesenchymal Ste

Senescent Cells: A Therapeutic Target in Cardiovascular Diseases

Merkel Cell Polyomavirus Large T Antigen Induces Cellular Senescence for Host Growth Arrest and Viral Genome Persistence

Emerging Therapeutic Approaches to Target the Dark Side of Senescent Cells: New Hopes to Treat Aging as a Disease and to

Age Is Just a Number: Progress and Obstacles in the Discovery of New Candidate Drugs for Sarcopenia

The Hippo Signaling Pathway Manipulates Cellular Senescence

Senescence and Aging: Does It Impact Cancer Immunotherapies?

Lipophilic Statins Eliminate Senescent Endothelial Cells by inducing Anoikis-Related Cell Death

Statins in Chronic Kidney Disease—Effects on Atherosclerosis and Cellular Senescence

In vitro senescence and senolytic functional assays.

Senolytic and senomorphic agent procyanidin C1 alleviates structural and functional decline in the aged retina

Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast ca

Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis.

Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies.

Oligodendrocytes in the aging brain

Hsp90 inhibitors as senolytic drugs to extend healthy aging

The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications

Senescent cells: targeting and therapeutic potential of senolytics in age-related diseases with a particular focus on th

From Development to Aging: The Path to Cellular Senescence

Ligand-specific regulation of a binary enhancer code dictating cellular senescence

Interacting NAD+ and Cell Senescence Pathways Complicate Antiaging Therapies

A focused natural compound screen reveals senolytic and senostatic effects of Isatis tinctoria

New Horizons in cellular senescence for clinicians.

Murine transfer of a human gene variant associated with exceptional longevity displays senolytic effects both in immune

Pharmacological Targeting of Senescence with ABT-263 in Experimental Heart Failure with Preserved Ejection Fraction

P08 Exploring the role of cellular senescence in cutaneous repair

Mitochondrial-Derived Peptides Exacerbate Senescence

Elimination of senescent cells targeting Senescence associated glycoprotein (SAGP) improved the ageing-associated diseas

Senolytics and cell senescence: historical and evolutionary perspectives.

Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis

Does Donor Age Have Effects on Senescence Biomarkers in Kidney-Transplanted Patients?

Digoxin reduces senescence and restores dysfunctional endothelial-subcutaneous adipocyte cross-talk and dysregulated glu

Anti-senescence therapies: a new concept to address cardiovascular disease.

National Institute on Aging Workshop: Repurposing Drugs or Dietary Supplements for Their Senolytic or Senomorphic Effect

Can removal of zombie cells revitalize the aging cardiovascular system?

The potential role and therapeutic relevance of cellular senescence in skeletal pathophysiology.

Allicin Reversed the Process of Frailty in Aging Male Fischer 344 Rats With Osteoporosis

Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway–UK Joint Meeting on Aging and Dementia: Recent Prog

Vaccination targeting senescence-associated transmembrane protein alleviated cardiovascular pathology in the mice

SAAM-1 senolytic vaccination alleviates atherosclerosis and cardiac dysfunction in mouse models

Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes

Cellular Senescence and Mammalian Healthspan

Understanding and targeting senescence in kidney disease.

Mitochondrial Dysfunction and Cellular Senescence Due to Aging Contributes to Prostatic Fibrosis

Pharmacological Interventions That Target Biological Aging

Aging, Senescent Cells, and Senolytic Drugs: The Path to Translation

IDENTIFYING SENOLYTIC TARGETS OF DIETARY FLAVONOIDS IN RENAL CELLS BY THERMAL PROTEOME PROFILING

Senescence and Its Role in Fibrosis

Targeting Senescent Cells to Counter Aging and Aging-Related Conditions

FUCOIDANS ARE NOVEL SENOTHERAPEUTICS THAT ENHANCE SIRT6 AND DNA REPAIR ACTIVITY

TRIALS AND TRIBULATIONS OF CONDUCTING A GEROSCIENCE TRIAL

SENOLYTIC DRUGS: DISCOVERY, TRANSLATION, AND APPLICATION

SENOLYTIC EFFECTS ON COGNITION, MOBILITY, AND BIOMARKERS IN OLDER ADULTS WITH MCI AND SLOW GAIT: A PILOT STUDY

The Translational Geroscience Network: Supporting a New Paradigm to Alleviate Age-Related Chronic Disease

P-337 A novel senotherapeutic strategy with azithromycin for preventing endometriosis progression

Therapeutic strategies targeting cellular senescence for cancer and other diseases

ORALLY ACTIVE, CLINICALLY TRANSLATABLE SENOLYTICS RESTORE Α-KLOTHO IN MICE AND HUMANS

DEVELOPMENT OF EPIGENETIC MEASURES FOR GEROSCIENCE CLINICAL TRIALS

The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions

Cellular senescence in the cancer microenvironment.

Macrophage Senescence: A New Axis in Inflammaging and MASLD with Implications for Senolytic Therapy

Functional diversity of senescent cells in driving ageing phenotypes and facilitating tissue regeneration.

Clinical Trials of Senolytics in Alzheimer’s Disease Treatment and Prevention

SENOTHERAPEUTICS, AGING, AND AGE-RELATED DISEASES

Brain Cell Senescence: A New Therapeutic Target for the Acute Treatment of Ischemic Stroke.

The Role of Cellular Senescence in Wound Healing of Diabetic Skin.

Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging.

A comparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats

Inflammatory cytokines secreted from senescent periodontal ligament cells influence the osteocyte network in alveolar bo

CAR-T cells leave the comfort zone: current and future applications beyond cancer

LGG-03. EXPLORING THE SIGNALING NETWORK INVOLVED IN MAPK PATHWAY INHIBITION BY THE MEK INHIBITOR TRAMETINIB IN BRAF-FUSI

Understanding senescence in clonal hematopoiesis 2837

Inhibition of PERK-mediated unfolded protein response acts as a switch for reversal of residual senescence and as senoly

LGG-27. Molecular implications of mitogen-activated protein kinase pathway inhibition by the MEK inhibitor trametinib in

- **DOI:** 10.1093/neuonc/noad179.0155 - **Authors:** Isha Mondal, Oishika Das, R. Lu, Winson S Ho - **Year:** 2023 - **

Cellular senescence of granulosa cells in the pathogenesis of polycystic ovary syndrome

DDDR-34. Bcl-xL inhibition enhances the efficacy of Temozolomide by targeting senescent glioblastoma cells

#2330 Fisetin supplement ameliorates aging related changes in the kidney

Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy.

- **DOI:** 10.1093/neuonc/noz175.1054 - **Authors:** Eliot Fletcher-Sananikone, B. Mukherjee, S. Burma - **Year:** 2019

LGG-14. INTEGRATED MULTI-OMICS EXPLORATION OF MAPK PATHWAY INHIBITION IN PEDIATRIC PILOCYTIC ASTROCYTOMA

Research Progress of Flavonoids Regulating Endothelial Function

Recent Advances in Potential Health Benefits of Quercetin

Effects of Fisetin, a Plant-Derived Flavonoid, on Response to Oxidative Stress, Aging, and Age-Related Diseases in Caeno

Challenges in the Vaccination of the Elderly and Strategies for Improvement

Immunomodulatory Activity of the Tyrosine Kinase Inhibitor Dasatinib to Elicit NK Cytotoxicity against Cancer, HIV Infec

Targeting Mitochondria to Control Ageing and Senescence

Network Pharmacology and Machine Learning Identify Flavonoids as Potential Senotherapeutics

Cellular Senescence in Health, Disease, and Lens Aging.

Curcumin-like Compound Inhibits Proliferation of Adenocarcinoma Cells by Inducing Cell Cycle Arrest and Senescence.

The Potential of Polyphenols in Modulating the Cellular Senescence Process: Implications and Mechanism of Action.

Researching New Drug Combinations with Senolytic Activity Using Senescent Human Lung Fibroblasts MRC-5 Cell Line

Senescent Cells in Early Vascular Ageing and Bone Disease of Chronic Kidney Disease-A Novel Target for Treatment.

Inflammation and Premature Ageing in Chronic Kidney Disease

Targeting Senescent Cells as Therapy for CKD.

The Occurrence of Senescence in the Arteriovenous Fistula in the Rat.

Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence

Natural Products Acting as Senolytics and Senomorphics Alleviate Cardiovascular Diseases by Targeting Senescent Cells

Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke

The effect of dihydroquercetin therapy on clinical status and the burden of senescent cells in elderly patients with chr

Senescence-Induced Atherosclerosis: The Potency of Senolytic Therapy

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-A

The Science of Aging: Therapeutic Approaches to Extend Lifespan and Healthspan

A Prospectively Created Living Organoid Biobank of Crohn’s Disease Patients Enables Integrative Therapeutics

Senotherapeutics and Their Molecular Mechanism for Improving Aging.

- **Authors:** P. Torres, R. Pamplona, M. Portero-Otín - **Year:** 2023 - **Journal:** Neural Regeneration Research - **

Epidermal Growth Factor Therapy Impact on Scar Tissue Resilience of Diabetic Lower Limbs Ulcers-An Enlightening Hypothes

Cardiac glycosides: Looking beyond heart failure and atrial fibrillation

The New Frontier of Ageing: Innovations and Insights in Gerontology

Dysfunctional stem and progenitor cells impair fracture healing with age

SENOLYTICS AND SENOMORPHICS: A NEW CLASS OF DRUGS FOR ANTI-AGING THERAPY

Moving from an “anti-aging” paradigm toward the concept of “disease-free aging”: the role of senolytics in modern medici

Senotherapeutics: emerging strategy for healthy aging and age-related disease

IPF and CPFE—The Two Different Entities or Two Different Presentations of the Same Disease?

Senolytics And Their Effects On Various Diseases

Molecular and cellular drivers of inflammaging: Uncovering the diverse mechanisms and interventions of inflammaging

Exploring the Evolution of Senotherapeutics Across Generations: A New Era in Human Dermal Fibroblast Senotherapy

Senescence of endplate osteoclasts induces sensory innervation and spinal pain

CSIG-02. RADIATION-INDUCED SENESCENCE AS A DRIVER OF GLIOBLASTOMA RECURRENCE

The ageing immune system as a potential target of senolytics

Interventional Strategies to Delay Aging Related Diseases &amp; Conditions of the Musculoskeletal System

ET-6 Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax

Depletion of senescent cells improves surgery-induced neuroinflammation in aged mice

Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human Adipose-Derived Stem Cells.

Stimulation of prostate cells by the senescence phenotype of epithelial and stromal cells: Implication for benign prosta

Cellular senescence in kidney diseases.

Senescence‐associated secretory phenotype promotes chronic ocular graft‐vs‐host disease in mice and humans

The senolytic drug fisetin mitigates age‐related bone density loss in the progeroid mouse model Zmpste24−/−

Elimination of Senescent Cells Attenuates Obesity‐Induced Increase in Sympathetic Nerve Activity

Procyanidin C1 inhibits bleomycin-induced pulmonary fibrosis in mice by selective clearance of senescent myofibroblasts.

Controlled induction and targeted elimination of p16INK4a‐expressing chondrocytes in cartilage explant culture

Muscle injury induces a transient senescence‐like state that is required for myofiber growth during muscle regeneration

Navigating the complex role of senescence in liver disease.

Senolytic Drugs, Dasatinib and Quercetin, Attenuate Adipose Tissue T Lymphocyte Infiltration and Improve Metabolic Funct

Senolytic procyanidin C1 alleviates renal fibrosis by promoting apoptosis of senescent renal tubular epithelial cells.

Wound healing: cellular mechanisms and pathological outcomes

Cellular senescence in renal ischemia-reperfusion injury.

Human umbilical cord mesenchymal stem cells-derived extracellular vesicles ameliorate kidney ischemia-reperfusion injury

Chronic HIV Infection and Aging: Application of a Geroscience-Guided Approach.

Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence.

Induction of Cellular Senescence in Rat Vaginal Fibroblasts and Treatment With Senolytics: An in Vitro Model for the Stu

Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical Translation.

From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs.

Senescence in pulmonary arterial hypertension: is there a link?

Ageing, cellular senescence and chronic kidney disease: experimental evidence.

Targeting Cellular Senescence with Senotherapeutics: Development of New Approaches for Skin Care

Research Highlights

Senotherapeutic peptide reduces skin biological age and improves skin health markers

Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral t

Death-seq identifies regulators of cell death and senolytic therapies

Targeting YAP-mediated HSC death susceptibility and senescence for treatment of liver fibrosis.

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress.

Targeting senescent cells with NKG2D-CAR T cells

A renal clearable fluorogenic probe for in vivo β-galactosidase activity detection during aging and senolysis

Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients&#x27; treatment.

Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models

The role of cellular senescence in ageing and endocrine disease.

The quest to slow ageing through drug discovery

Mechanisms and therapeutic implications of cellular senescence in osteoarthritis.

Cellular senescence and senolytics: the path to the clinic

Senescence as a therapeutic target in cancer and age-related diseases

Senolytic therapy in mild Alzheimer&#x27;s disease: a phase 1 feasibility trial.

Cellular senescence: the good, the bad and the unknown

Cellular senescence in ageing: from mechanisms to therapeutic opportunities.

Immunotherapy and senolytics in head and neck squamous cell carcinoma: phase 2 trial results.

Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.

The metabolic roots of senescence: mechanisms and opportunities for intervention.

Cardiac glycosides are broad-spectrum senolytics.

A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma i

Strategies for targeting senescent cells in human disease

Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog

Targeting the senescence-associated secretory phenotype to modify osteoarthritis in aging.

Senotherapeutic repurposing of metformin for age-related diseases and their signaling pathways.

Cellular senescence in glioma.

Balancing senescence and apoptosis: therapeutic insights into aging and cancer.

Long-term dasatinib plus quercetin effects on aging outcomes and inflammation in nonhuman primates: implications for sen

Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumar

Targeting Cell Senescence for the Treatment of Age-Related Bone Loss.

The senolytic cocktail, dasatinib and quercetin, impacts the chromatin structure of both young and senescent vascular sm

Liver Regeneration: Polyploidy and Cellular Senescence as Potential Regulators.

Anti-aging Factor GRSF1 Attenuates Cerebral Ischemia-Reperfusion Injury in Mice by Inhibiting GPX4-Mediated Ferroptosis.

Senolytics: The Modern Snake Oil?

Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion

Antiaging agents: safe interventions to slow aging and healthy life span extension

Potential Role of Polyphenolic Flavonoids as Senotherapeutic Agents in Degenerative Diseases and Geroprotection

The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis.

Current and Future Treatment Landscape for Idiopathic Pulmonary Fibrosis

Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics.

Cellular Senescence in Idiopathic Pulmonary Fibrosis

Mitochondria-associated cellular senescence mechanisms: Biochemical and pharmacological perspectives.

Pharmacological frontiers in senescence: Transforming senescence with drug repurposing.

Targeting treatment resistance in cervical cancer: A new avenue for senolytic therapies.

mTOR as a senescence manipulation target: A forked road.

Cellular senescence in aging: Molecular basis, implications and therapeutic interventions.

Extracellular vesicles from mesenchymal stromal cells: Therapeutic perspectives for targeting senescence in osteoarthrit

Molecular imaging for senescent cells-targeted therapeutics in aging and age-related diseases.

Cell Survival, Death, and Proliferation in Senescent and Cancer Cells: the Role of (Poly)phenols.

Targeting normal and cancer senescent cells as a strategy of senotherapy.

Senotherapeutic approach to age-related endocrine diseases.

Molecular pathology endpoints useful for aging studies.

Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications.

Cellular senescence and senotherapeutics in cardiovascular diseases.

Biomaterials targeting senescent cells for bone regeneration: State-of-the-art and future perspectives.

Combined use of dasatinib and quercetin alleviates overtraining-induced deficits in learning and memory through eliminat

Unraveling the meta-hallmarks between senescent and tumor cells: A new perspective for senolytic drug discovery.

Proteolysis-targeting chimera (PROTAC): A promising senolytic strategy.

First evidence that senolytics are effective at decreasing senescent cells in humans

Senolytic-Mediated Elimination of Head and Neck Tumor Cells Induced Into Senescence by Cisplatin

Senolytic Combination of Dasatinib and Quercetin Promotes Tendon-to-Bone Healing by Mitigating Age-Related Senescence in