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A novel LED‐based 2D‐fluorescence spectroscopy system for in‐line monitoring of Chinese hamster ovary cell cultivations
Insights into the Impact of Rosmarinic Acid on CHO Cell Culture Improvement through Transcriptomics Analysis
Temperature Down‐Shift Modifies Expression of UPR‐/ERAD‐Related Genes and Enhances Production of a Chimeric Fusion Prote
Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclo
Genome-scale functional genomics screening highlights genes impacting protein fucosylation in Chinese hamster ovary cell
Impact Factors in the Process Development for Therapeutic Antibodies
Multi‐omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer, and
Amino acid feeding reduces ammonia production through rearrangement of metabolic fluxes in central carbon metabolism of
Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Sp
Optimization of human interferon beta protein expression in Chinese hamster ovary cells
Prediction of N-linked Glycoform Profiles of Monoclonal Antibody with Extracellular Metabolites and Two-Step Intracellul
Analysis of Golgi pH in Chinese hamster ovary cells using ratiometric pH‐sensitive fluorescent proteins
Metabolic Control in Mammalian Fed-Batch Cell Cultures for Reduced Lactic Acid Accumulation and Improved Process Robustn
Advances in recombinant antibody manufacturing
A genome-scale metabolic network model and machine learning predict amino acid concentrations in Chinese Hamster Ovary c
pH excursions impact CHO cell culture performance and antibody N-linked glycosylation.
Modulating and optimizing Pluronic F-68 concentrations and feeding for intensified perfusion Chinese hamster ovary cell
Sodium chloride impacts glycosylation and N‐ and O‐glycan site occupancy of an Fc‐fusion protein
Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture super
Automated Shape and Process Parameter Optimization for Scaling Up Geometrically Non-Similar Bioreactors
Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells
A system identification approach for developing model predictive controllers of antibody quality attributes in cell cult
NAD<sup>+</sup> supplementation improves mAb productivity in CHO cells via a glucose metabolic shift
Modulation of N-Glycosylation in Bispecific Antibody Biosimilars through Combined Modulators
Strategies to control therapeutic antibody glycosylation during bioprocessing: Synthesis and separation
Impact of iron raw materials and their impurities on CHO metabolism and recombinant protein product quality
Model-Based Optimization of a Fed-Batch Bioreactor for mAb Production Using a Hybridoma Cell Culture
Application of bioreactor technology for cell culture-based viral vaccine production: Present status and future prospect
Selection of chemically defined media for CHO cell fed-batch culture processes
CHO stable pool fed‐batch process development of SARS ‐ CoV ‐2 spike protein production: Impact of aeration conditions a
An automated high inoculation density fed‐batch bioreactor, enabled through N‐1 perfusion, accommodates clonal diversity
Engineering Oxidative Stress Resistance in CHO Cell Factories
A statistical approach to improve compound screening in cell culture media
Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data-driven and model-guided anal
Responses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabol
The effect of amino acid supplementation in an industrial Chinese Hamster Ovary process.
A system identification approach for developing model predictive controllers of antibody quality attributes in cell cult
Glucose withdrawal-induced Chinese hamster ovary cells apoptosis and its potential role in process robustness assessment
Multi‐Omics Reveals Impact of Cysteine Feed Concentration and Resulting Redox Imbalance on Cellular Energy Metabolism an
Exploring cellular behavior under transient gene expression and its impact on mAb productivity and Fc‐glycosylation
Reduction of IL-2 fragmentation during manufacturing of a novel immunocytokine by DoE process optimization.
Identifying a robust design space for glycosylation during monoclonal antibody production.
Rapid Antibody Glycoengineering in Chinese Hamster Ovary Cells
An Improved Cell Culture Process for Production of Omalizumab
Intracellular CHO cell metabolite profiling and in vivo monitoring of redox state unravel the effect of temperature down
Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time
Identification of process conditions influencing protein aggregation in Chinese hamster ovary cell culture.
Development of soft sensors for monitoring and control of bioprocesses
Rich production media as a platform for CHO cell line development
High Cell Density Perfusion Culture has a Maintained Exoproteome and Metabolome
Continuous optical in‐line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency w
Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to
CHOmpact: a reduced metabolic model of Chinese hamster ovary cells with enhanced interpretability
Minimizing batch‐to‐batch variability of a live virus vaccine by process analytical technologies
Assessment of fed-batch cultivation strategies for an inducible CHO cell line.
Intracellular response to process optimization and impact on productivity and product aggregates for a high-titer CHO ce
COSMIC-dFBA: A novel multi-scale hybrid framework for bioprocess modeling
Soft‐sensors application for automated feeding control in high‐throughput mammalian cell cultures
Sensor Selection and State Estimation of Continuous mAb Production Processes
Investigation of cell line specific responses to pH inhomogeneity and consequences for process design
Single cell analysis of Chinese hamster ovary cells during a bioprocess using a novel dynamic imaging system
Using MVDA with Stoichiometric Balances to Optimize Amino Acid Concentrations in Chemically Defined CHO Cell Culture Med
Accelerating Biologics Manufacturing by Upstream Process Modelling
Purification and Analytics of a Monoclonal Antibody from Chinese Hamster Ovary Cells Using an Automated Microbioreactor
Evaluation of NAD+ precursors for improved metabolism and productivity of antibody‐producing CHO cell
Optimization of human interferon beta protein expression in Chinese hamster ovary cells
Modeling the Effect of Amino Acids and Copper on Monoclonal Antibody Productivity and Glycosylation: A Modular Approach
Metabolic engineering of CHO cells for the development of a robust protein production platform
Development of a miniature bioreactor model to study the impact of pH and DOT fluctuations on CHO cell culture performan
Supplementation Strategies for Tuning Glycosylation of Monoclonal Antibodies and Enhancing Growth in Mammalian Cell Cult
BioDT: An Integrated Digital-Twin-Based Framework for Intelligent Biomanufacturing
An assessment of the impact of Raman based glucose feedback control on CHO cell bioreactor process development
Expression of recombinant classical swine fever virus E2 glycoprotein by endogenous Txnip promoter in stable transgenic
Developing microRNAs as engineering tools to modulate monoclonal antibody galactosylation
Identification of Mispairing Omic Signatures in Chinese Hamster Ovary (CHO) Cells Producing a Tri-Specific Antibody
Improved Titer in Late-Stage Mammalian Cell Culture Manufacturing by Re-Cloning
Lectin bio‐layer interferometry for assessing product quality of Fc‐ glycosylated immunoglobulin G
Manipulation of mRNA translation elongation influences the fragmentation of a biotherapeutic Fc‐fusion protein produced
The microRNomes of Chinese Hamster Ovary (CHO) cells and their extracellular vesicles, and how they respond to osmotic a
Multi-omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer and
Kinetic modeling as a tool to understand the influence of cell culture process parameters on the glycation of monoclonal
Single cell analysis and quantitative modelling of ion concentrations and dielectric properties of Chinese hamster ovary
Production of novel SARS‐CoV‐2 Spike truncations in Chinese hamster ovary cells leads to high expression and binding to
Production of Trimeric SARS-CoV-2 Spike Protein by CHO Cells for Serological COVID-19 Testing
Control of IgG glycosylation by in situ and real‐time estimation of specific growth rate of CHO cells cultured in biorea
Hierarchical time‐series analysis of dynamic bioprocess systems
Expression and Purification of Soluble, Glycosylated T‐cell Receptors in Chinese Hamster Ovary Cells
Expression of recombinant classical swine fever virus E2 glycoprotein by endogenous Txnip promoter in stable transgenic
On-line reoptimization of mammalian fed-batch culture using a nonlinear model predictive controller
Kinetic modeling: A tool for temperature shift and feeding optimization in cell culture process development.
Hyperosmolality in CHO culture: Effects on cellular behavior and morphology
A practical approach in bioreactor scale-up and process transfer using a combination of constant P/V and vvm as the crit
Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/
Establishment and optimization of a high-throughput mimic perfusion model in ambr® 15.
Real‐time dissolved carbon dioxide monitoring II: Surface aeration intensification for efficient CO<sub>2</sub> removal
Optimization of a mAb production process with regard to robustness and product quality using quality by design principle
Exploring cellular behavior under transient gene expression and its impact on mAb productivity and Fc‐glycosylation
Identification of Cell Culture Factors Influencing Afucosylation Levels in Monoclonal Antibodies by Partial Least-Square
Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Pr
Evaluating the impact of media and feed combinations on CHO cell culture performance and monoclonal antibody (trastuzuma
Impact of Acetylated and Non-Acetylated Fucose Analogues on IgG Glycosylation
Fluctuations in dissolved oxygen concentration during a CHO cell culture process affects monoclonal antibody productivit
Expanding the understanding of viral tropism by characterizing the N-glycomic profiles of transducible cell lines and ti
Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster
Media on‐demand: Continuous reconstitution of a chemically defined media directly from solids
Real‐time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture usi
Strategies Used in Manufacturing Processes to Drive and Control Mammalian Cells to Undergo a Lactate Metabolic Shift
Biopharmaceutical Manufacturing: Historical Perspectives and Future Directions
A novel LED‐based 2D‐fluorescence spectroscopy system for in‐line bioprocess monitoring of Chinese hamster ovary cell cu
Interest of locally weighted regression to overcome nonlinear effects during in situ NIR monitoring of CHO cell culture
Rosmarinic acid enhances CHO cell productivity and proliferation through activation of the unfolded protein response and
Investigation of the influence of large scale occurring pH heterogeneities on CHO cells
Recent Advances in Biologic Therapeutic N-Glycan Preparation Techniques and Analytical Methods for Facilitating Biomanuf
Development, characterization, and application of a 2‐Compartment system to investigate the impact of pH inhomogeneities
Advancements in CHO metabolomics: techniques, current state and evolving methodologies
Enhancement of adalimumab expression in CHO cells by antioxidant small molecule additives and the underlying mechanism
Rapid development of clone‐specific, high‐performing perfusion media from established feed supplements
Production and characterization of active recombinant human factor II with consistent sialylation.
Multi-omics analysis of Chinese hamster ovary cell-based biopharmaceutical production processes
Off-Gas-Based Soft Sensor for Real-Time Monitoring of Biomass and Metabolism in Chinese Hamster Ovary Cell Continuous Pr
Towards robust cell culture processes — Unraveling the impact of media preparation by spectroscopic online monitoring
A class of low‐cost alternatives to kifunensine for increasing high mannose N‐linked glycosylation for monoclonal antibo
Kinetic modeling: A tool for temperature shift and feeding optimization in cell culture process development.
Systematic Approaches to Identification of Dynamic Flux Balance Models
Towards advanced bioprocess optimization: A multiscale modelling approach
A hierarchical model combining process and Raman spectroscopic data for real-time monitoring of cell culture process
Population balance modelling captures host cell protein dynamics in CHO cell cultures
SPRi cytometry: sensitively sensing the sensitive side of cells
Multivariate data analysis of growth medium trends affecting antibody glycosylation
A statistical approach to improve compound screening in cell culture media
The impact of expression vector position on transgene transcription allows for rational expression vector design in a ta
Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data-driven and model-guided anal
Defective mucin-type glycosylation on α-dystroglycan in COG-deficient cells increases its susceptibility to bacterial pr
Control of IgG glycosylation by in situ and real‐time estimation of specific growth rate of CHO cells cultured in biorea
PID controls: the forgotten bioprocess parameters
Hyperosmolality in CHO cell culture: effects on the proteome
Stable overexpression of native and artificial miRNAs for the production of differentially fucosylated antibodies in CHO
Mammalian cell lines used in bioprocessing
Intracellular CHO cell metabolite profiling and in vivo monitoring of redox state unravel the effect of temperature down
Microevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactat
COMPREHENSIVE EVALUATION OF EXPRESSION PLATFORM: CHERRY PICKING THE ‘RIGHT’ TO ACCOMPLISH THE ‘BEST
Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing uni
Choice of Host Cell Line Is Essential for the Functional Glycosylation of the Fc Region of Human IgG1 Inhibitors of Infl
Repressing expression of difficult‐to‐express recombinant proteins during the selection process increases productivity o
Designing a Strategy for pH Control to Improve CHO Cell Productivity in Bioreactor.
Characterization of Chinese Hamster Ovary Cell Performance with Pentanoic Acid and N-Acetyl Cysteine Treatment
Halfway to Automated Feeding of Chinese Hamster Ovary Cells
A Novel, Site‐Specific N‐Linked Glycosylation Model Provides Mechanistic Insights Into the Process‐Condition Dependent D
Developing a medium combination to attain similar glycosylation profile to originator by DoE and cluster analysis method
Theoretical justification of selecting a method for cultivation of mammal cells as a basis for designing membrane biorea
Purification and Analytics of a Monoclonal Antibody from Chinese Hamster Ovary Cells Using an Automated Microbioreactor
Glycoprofiling effects of media additives on IgG produced by CHO cells in fed‐batch bioreactors
Shortening the Biologics Clinical Timeline with a Novel Method for Generating Stable, High Producing Cell Pools and Clon
High Cell Density Perfusion Culture has a Maintained Exoproteome and Metabolome
Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells
Hyperosmolality in CHO culture: Effects on cellular behavior and morphology
Evaluation of feed strategy for high quality biosimilar IgG production in CHO cell fed-batch process
Towards the Development of Automated Fed-Batch Cell Culture Processes at Microscale
Calibration transfer for bioprocess Raman monitoring using Kennard Stone piecewise direct standardization and multivaria
Process‐induced cell cycle oscillations in CHO cultures: Online monitoring and model‐based investigation
Impact of iron raw materials and their impurities on CHO metabolism and recombinant protein product quality
Modeling, estimation, and control of glycosylation in monoclonal antibodies produced in CHO cells
Multivariate data analysis of growth medium trends affecting antibody glycosylation
Multiplex secretome engineering enhances recombinant protein production and purity
A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering
Modulation and modeling of monoclonal antibody N-linked glycosylation in mammalian cell perfusion reactors.
Automated Workflow for Instant Labeling and Real-Time Monitoring of Monoclonal Antibody N-Glycosylation
Nucleotide and Nucleotide Sugar Analysis in Cell Extracts by Capillary Electrophoresis
Hyperosmotic stimulus study discloses benefits in ATP supply and reveals miRNA/mRNA targets to improve recombinant prote
Development of hyper osmotic resistant CHO host cells for enhanced antibody production.
Exploring synthetic biology for the development of a sensor cell line for automated bioprocess control
Perfusion-Based Antibody Production in the Ambr<sup>®</sup> 250 Modular
Hierarchical time‐series analysis of dynamic bioprocess systems
Transcriptome Analysis of CHO Cell Size Increase During a Fed-Batch Process
Mammalian cell perfusion culture development for integrated continuous biomanufacturing
Modulation of Antibody Glycosylation in Chinese Hamster Ovary Cells: Experimental and Computational Analyses Provide Mec
A 0.7pArms Electrochemical Readout IC for Continuous Monitoring of Antibody Biologics in Upstream Biomanufacturing
Feasibility and performance of cross‐clone Raman calibration models in CHO cultivation
A robust scale-down model development and process characterization for monoclonal antibody biomanufacturing using multiv
Process intensification to produce a difficult‐to‐express therapeutic enzyme by high cell density perfusion or enhanced
High-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loo
Application of the Bradford Assay for Cell Lysis Quantification: Residual Protein Content in Cell Culture Supernatants
Combination of temperature shift and hydrolysate addition regulates anti-IgE monoclonal antibody charge heterogeneity in
Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells
Using Metabolomics to Identify Cell Line-Independent Indicators of Growth Inhibition for Chinese Hamster Ovary Cell-Base
Dissecting cell death pathways in fed‐batch bioreactors
Real‐time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture usi
Process transfer and optimization of Chinese hamster ovary cell cultivation for monoclonal antibody production
Effects of enzymatically-synthesized sialylated oligosaccharides on the N- and O-glycosylation of etanercept in recombin
Real‐time monitoring of specific oxygen uptake rates of embryonic stem cells in a microfluidic cell culture device
Trace metal optimization in CHO cell culture through statistical design of experiments
Systematic Approaches to Identification of Dynamic Flux Balance Models
Gene editing in CHO cells to prevent proteolysis and enhance glycosylation: Production of HIV envelope proteins as vacci
Feasibility and performance of cross‐clone Raman calibration models in CHO cultivation
Control of IgG glycosylation in CHO cell perfusion cultures by GReBA mathematical model supported by a novel targeted fe
Enhancing and stabilizing monoclonal antibody production by Chinese hamster ovary (CHO) cells with optimized perfusion c
Model-based optimization of antibody galactosylation in CHO cell culture.
Trace metal optimization in CHO cell culture through statistical design of experiments
Scale-up of a monoclonal antibody CHO fed-batch production in stirred tank bioreactors: Effect of hydrodynamic condition
Profiling the dynamic changes in the phosphoproteome of Chinese hamster ovary cells
Impact of cell culture media additives on IgG glycosylation produced in Chinese hamster ovary cells
Unveiling the CHO surfaceome: Identification of cell surface proteins reveals cell aggregation‐relevant mechanisms
Novel Platforms for Large-Scale Adherent Culture of Mammalian Cells
Implementation of Design of Experiments (DOE) for Optimization of Feeding Strategy and Glyco-Engineering of Trastuzumab
An automated high inoculation density fed‐batch bioreactor, enabled through N‐1 perfusion, accommodates clonal diversity
Effective temperature shift strategy development and scale confirmation for simultaneous optimization of protein product
Boosting Productivity for Advanced Biomanufacturing by Re-Using Viable Cells.
Maximum entropy and population heterogeneity in continuous cell cultures
Enhancement of adalimumab expression in CHO cells by antioxidant small molecule additives and the underlying mechanism
Combination of temperature shift and hydrolysate addition regulates anti-IgE monoclonal antibody charge heterogeneity in
Main Quality Attributes of Monoclonal Antibodies and Effect of Cell Culture Components
A semi-empirical glycosylation model of a camelid monoclonal antibody under hypothermia cell culture conditions
Multivariate data analysis of process parameters affecting the growth and productivity of stable Chinese hamster ovary c
MicroRNA Profiling and Engineering of CHO Cell Lines Stably Expressing Difficult-to-Express Lysosomal Protein
Development of a miniature bioreactor model to study the impact of pH and DOT fluctuations on CHO cell culture performan
Modulating and optimizing Pluronic F‐68 concentrations and feeding for intensified perfusion Chinese hamster ovary cell
Small scale bioprocess optimization using soft sensors
Amélioration de la production et de la qualité des protéines thérapeutiques recombinantes produites en culture en mode c
N‐glycosylation regulates MET processing and signaling
Characterization of intact glycopeptides reveals the impact of culture media on site‐specific glycosylation of EPO‐Fc fu
Mimicking CHO large‐scale effects in the single multicompartment bioreactor: A new approach to access scale‐up behavior
Segmented linear modeling of CHO fed‐batch culture and its application to large scale production
Clever Experimental Designs: Shortcuts for Better iPSC Differentiation
Differential effects of bioreactor process variables and purification on the human recombinant lysosomal enzyme β-glucur
Functional characterization of a SNP (F51S) found in human alpha 1‐antitrypsin
Multi-omic characterization of antibody-producing CHO cell lines elucidates metabolic reprogramming and nutrient uptake
Autophagy-inducing Peptide Increases CHO Cell Monoclonal Antibody Production in Batch and Fed-batch Cultures
Understanding and Controlling Sialylation in a CHO Fc-Fusion Process
Dissecting cell death pathways in fed‐batch bioreactors
Investigating the impact of synonymous gene recoding on a recombinantly expressed monoclonal antibody under different pr
13C LABELING FOR CHO CELL METABOLISM TRACING AND MS BASED ANALYSIS FOR ADVANCED UPSTREAM CULTURE MONITORING TO SUPPORT C
Microevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactat
Effects of cysteine, asparagine, or glutamine limitations in Chinese hamster ovary cell batch and fed‐batch cultures
WITHDRAWN
Impact of DO, agitation, aeration and copper concentration on lactate metabolism and charge heterogeneity for monoclonal
Equal mixing time enables scale-down and optimization of a CHO cell culture process using a shaken microbioreactor syste
Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided
CHOmpact: A reduced metabolic model of Chinese hamster ovary cells with enhanced interpretability
Data-driven modeling of the degradation of recombinant proteins in Chinese hamster ovary cells
Application of liquid chromatography-mass spectrometry-based protein and proteomic analytical approaches to chinese hams
Purification and Analytics of a Monoclonal Antibody from Chinese Hamster Ovary Cells Using an Automated Microbioreactor
Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothe
Mimicking CHO large‐scale effects in the single multicompartment bioreactor: A new approach to access scale‐up behavior
Measurement and control of foam generation in a mammalian cell culture
MicroRNA Profiling and Engineering of CHO Cell Lines Stably Expressing Difficult-to-Express Lysosomal Protein
Process‐induced cell cycle oscillations in CHO cultures: Online monitoring and model‐based investigation
Data-driven digital twin models for forecasting multi-step ahead profiles of mammalian cell culture performance
Real‐time quantification and supplementation of bioreactor amino acids to prolong culture time and maintain antibody pro
mRNA Transfection into CHO‐Cells Reveals Production Bottlenecks
Methods for Using Small Non-Coding RNAs to Improve Recombinant Protein Expression in Mammalian Cells
Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch a
Fluctuations in dissolved oxygen concentration during a CHO cell culture process affects monoclonal antibody productivit
mAb Production Modeling and Design Space Evaluation Including Glycosylation Process
WITHDRAWN
Quantifying the impact of cell culture media on CHO cell growth and protein production.
New high-throughput screening method for Chinese hamster ovary cell lines expressing low reduced monoclonal antibody lev
Glycoengineering in CHO Cells: Advances in Systems Biology
Development of DNA and recombinant vaccines against toxoplasma gondii infection / Ching Xiao Teng
Debottlenecking Opportunities Clearer with a Bioprocessing 4.0 Perspective
Development and application of quantitative liquid chromatography – mass spectrometry techniques to facilitate enhanced
An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation
Investigating Low Culture Temperature and Low Media pH of Two Chinese Hamster Ovary (CHO) Cell Lines with Next Generatio
Metabolic characterization of a CHO cell size increase phase in fed-batch cultures
Glycosylation Flux Analysis of Immunoglobulin G in Chinese Hamster Ovary Perfusion Cell Culture
A protocol to transfer a fed‐batch platform process into semi‐perfusion mode: The benefit of automated small‐scale biore
Uridine modulates monoclonal antibody charge heterogeneity in Chinese hamster ovary cell fed-batch cultures
Modeling the Effect of Amino Acids and Copper on Monoclonal Antibody Productivity and Glycosylation: A Modular Approach
Use of spectroscopic process analytical technology for rapid quality evaluation during preparation of CHO cell culture m
Dynamic pH profiles drive higher cell-specific and volumetric productivity.
Application of metabolic modeling for targeted optimization of high seeding density processes
Modulating antibody N-glycosylation through feed additives using a multi-tiered approach
Progress in fed-batch culture for recombinant protein production in CHO cells
Intracellular Profiling for Biopharmaceutical Cultivation Processes
Modeling of cell cultivation for monoclonal antibody production processes considering lactate metabolic shifts.
Enhancing the functionality of a microscale bioreactor system as an industrial process development tool for mammalian pe
Temperature Down‐Shift Modifies Expression of UPR‐/ERAD‐Related Genes and Enhances Production of a Chimeric Fusion Prote
The effect of hyperosmolality application time on production, quality, and biopotency of monoclonal antibodies produced
Nutrient supplementation strategy improves cell concentration and longevity, monoclonal antibody production and lactate
Enhancing the functionality of a microscale bioreactor system as an industrial process development tool for mammalian pe
Combining Butyrated ManNAc with Glycoengineered CHO Cells Improves EPO Glycan Quality and Production.
Model‐based investigation of intracellular processes determining antibody Fc‐glycosylation under mild hypothermia
Online control of cell culture redox potential prevents antibody interchain disulfide bond reduction.
Deciphering Metabolic Pathways in High-Seeding-Density Fed-Batch Processes for Monoclonal Antibody Production: A Computa
Calibration design for pharmaceutical bioprocesses: A novel approach for knowledge transfer in Design of Experiments
Scale-down of CHO cell fed-batch cultures
Novel Platforms for Large-Scale Adherent Culture of Mammalian Cells
Insight into the roles of tyrosine on rCHO cell performance in fed-batch cultures.
Use of spectroscopic process analytical technology for rapid quality evaluation during preparation of CHO cell culture m
Mathematical model of the multi-amino acid multi-transporter system predicts uptake flux in CHO cells
Methylthioadenosine (MTA) boosts cell‐specific productivities of Chinese hamster ovary cultures: dosage effects on proli
Mathematical modelling for bioprocess understanding and optimisation
Effects of pyruvate on primary metabolism and product quality for a high‐density perfusion process
An arrayed CRISPR screen reveals Myc depletion to increase productivity of difficult-to-express complex antibodies in CH
Sequential active learning for medium optimization in mAb production.
Impacts of intentional mycoplasma contamination on CHO cell bioreactor cultures
Modulation of N-Glycosylation in Bispecific Antibody Biosimilars through Combined Modulators
Continuous optical in‐line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency w
A novel approach to noninvasive monitoring of dissolved carbon dioxide in small-scale cell culture processes
A Simple Method to Reduce both Lactic Acid and Ammonium Production in Industrial Animal Cell Culture
A novel hybrid bioprocess strategy addressing key challenges of advanced biomanufacturing
Single cell analysis and quantitative modelling of ion concentrations and dielectric properties of Chinese hamster ovary
“Organized stress” for robust scale‐up of intensified production process with fed‐batch seed bioreactor
Analysis of coagulation factor IX in bioreactor cell culture medium predicts yield and quality of the purified product
Towards the Development of Automated Fed-Batch Cell Culture Processes at Microscale
High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat
Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells
Comparing Kinetic versus Stoichiometric Priorities in Hybrid Models of CHO Metabolism
Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures
C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system
Stress‐induced increase of monoclonal antibody production in CHO cells
Chemical inhibitors of hexokinase‐2 enzyme reduce lactate accumulation, alter glycosylation processing, and produce alte
PAT-on-a-chip: Miniaturization of analytical assays towards data-driven bioprocess development and optimization.
Enzyme capacity-based genome scale modelling of CHO cells
Improving culture performance and antibody production in CHO cell culture processes by reducing the Warburg effect.
Bioprocessing of Recombinant CHO-K1, CHO-DG44, and CHO-S: CHO Expression Hosts Favor Either mAb Production or Biomass Sy
Characterization of Chinese Hamster Ovary Cell Performance with Pentanoic Acid and N-Acetyl Cysteine Treatment
Towards advanced bioprocess optimization: A multiscale modelling approach
Therapeutic Fc fusion protein misfolding: A three-phasic cultivation experimental design
AI-Driven Insights into the complexities of Chinese hamster ovary cells death in order to optimize production processes
Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biom
Inducible transgene expression in CHO cells using an artificial transcriptional activator with estrogen-binding domain
Hyperosmolarity Triggers the Warburg Effect in Chinese Hamster Ovary Cells and Reveals a Reduced Mitochondria Horsepower
Correlation and Predictive Modeling of Extracellular Cell Culture Metabolites to Drug Product Titer and Cellular Viabili
Polysome profiling of mAb producing CHO cell lines links translational control of cell proliferation and recombinant mRN
Baicalein Reduces Oxidative Stress in CHO Cell Cultures and Improves Recombinant Antibody Productivity
Enhancing Recombinant Monoclonal Antibody Production in CHO Cell Cultures: Leveraging the Power of Multivariate Analysis
Lectin bio‐layer interferometry for assessing product quality of Fc‐ glycosylated immunoglobulin G
Impact of media and antifoam selection on monoclonal antibody production and quality using a high throughput micro‐biore
Multi-omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer and
Additions to recombinant proteins for delivery and function
Investigation of the influence of large scale occurring pH heterogeneities on CHO cells
A Systematic Approach to Time-series Metabolite Profiling and RNA-seq Analysis of Chinese Hamster Ovary Cell Culture
Towards Autonomous Process Control—Digital Twin for CHO Cell-Based Antibody Manufacturing Using a Dynamic Metabolic Mode
Improvement of Recombinant Proteins Production by Inducing Mitochondrial Biogenesis in CHO Cell Culture
Inducible transgene expression in CHO cells using an artificial transcriptional activator with estrogen-binding domain
Effect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human T
Ouantitative Proteomic Analysis of Cellular Responses to a Designed Amino Acid Feed in a Monoclonal Antibody Producing C
Exploring the linkage between cell culture process parameters and downstream processing utilizing a plackett-burman desi
Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation
An assessment of the impact of Raman based glucose feedback control on CHO cell bioreactor process development
Calibration transfer for bioprocess Raman monitoring using Kennard Stone piecewise direct standardization and multivaria
Modulation of high mannose levels in N-linked glycosylation through cell culture process conditions to increase antibody
A novel LED‐based 2D‐fluorescence spectroscopy system for in‐line monitoring of Chinese hamster ovary cell cultivations
Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis
Systematic development of temperature shift strategies for Chinese hamster ovary cells based on short duration cultures
CO&lt;sub&gt;2&lt;/sub&gt; Control Strategy for Large-Scale Cell Culture Bioreactor Operation
Platform development for high‐throughput optimization of perfusion processes—Part II: Variation of perfusion rate strate
Investigation of cell line specific responses to pH inhomogeneity and consequences for process design
Reduction of charge variants by CHO cell culture process optimization.
Development and application of quantitative liquid chromatography – mass spectrometry techniques to facilitate enhanced
A practical approach in bioreactor scale-up and process transfer using a combination of constant P/V and vvm as the crit
A comparison of orbitally‐shaken and stirred‐tank bioreactors: pH modulation and bioreactor type affect CHO cell growth
Secondary feed filtration and storage conditions influence trace element availability and process performance at 2000 L
Cell culture media supplemented with raffinose reproducibly enhances high mannose glycan formation.
A novel LED‐based 2D‐fluorescence spectroscopy system for in‐line bioprocess monitoring of Chinese hamster ovary cell cu
Modulation of high mannose levels in N-linked glycosylation through cell culture process conditions to increase antibody
Evaluation of feed strategy for high quality biosimilar IgG production in CHO cell fed-batch process
Use of single analytic tool to quantify both absolute N‐glycosylation and glycan distribution in monoclonal antibodies
Serum-Free Medium for Recombinant Protein Expression in Chinese Hamster Ovary Cells
Real‐time monitoring of specific oxygen uptake rates of embryonic stem cells in a microfluidic cell culture device
Amélioration de la production et de la qualité des protéines thérapeutiques recombinantes produites en culture en mode c
Enhancing Recombinant Monoclonal Antibody Production in CHO Cell Cultures: Leveraging the Power of Multivariate Analysis
FACTORS AFFECTING CHINESE HAMSTER OVARY CELL PROLIFERATION AND VIABILITY
Enhancement of anti-TNFα monoclonal antibody production in CHO cells through the use of UCOE and DHFR elements in vector
Characterization of mammalian cell culture raw materials by combining spectroscopy and chemometrics
Elevated pCO<sub>2</sub> affects the lactate metabolic shift in CHO cell culture processes
Model‐based investigation of intracellular processes determining antibody Fc‐glycosylation under mild hypothermia
Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells
Multi-omics analysis of Chinese hamster ovary cell-based biopharmaceutical production processes
Integration of Time-Series Transcriptomic Data with Genome-Scale CHO Metabolic Models for mAb Engineering
Modulation of nutrient precursors for controlling metabolic inhibitors by genome‐scale flux balance analysis
Enhancement of effector functions of anti-CD20 monoclonal antibody by increased afucosylation in CHO cell line through c
Applying intensified design of experiments to mammalian cell culture processes
Osmolality Effects on CHO Cell Growth, Cell Volume, Antibody Productivity and Glycosylation
Amino acid feeding reduces ammonia production through rearrangement of metabolic fluxes in central carbon metabolism of
In‐line monitoring of amino acids in mammalian cell cultures using raman spectroscopy and multivariate chemometrics mode
In‐line monitoring of amino acids in mammalian cell cultures using raman spectroscopy and multivariate chemometrics mode
Implementation of QbD strategies in the inoculum expansion of a mAb production process
Production of trimeric SARS‐CoV‐2 spike protein by CHO cells for serological COVID‐19 testing
Chemical inhibitors of hexokinase‐2 enzyme reduce lactate accumulation, alter glycosylation processing, and produce alte
Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided
Multi-omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer, and
Investigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critic
High‐throughput screening of antibody‐expressing CHO clones using an automated shaken deep‐well system
<i>S</i>‐adenosylmethionine and methylthioadenosine boost cellular productivities of antibody forming Chinese hamster ov
Process intensification in fed-batch production bioreactors using non-perfusion seed cultures
QbD-guided pharmaceutical development of Pembrolizumab biosimilar candidate PSG-024 propelled to industry meeting primar
cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV‐1 envelope glycoprotein vacci
Soft‐sensors application for automated feeding control in high‐throughput mammalian cell cultures
Identification of novel miRNA targets in CHO cell lines and characterization of their impact on protein N-glycosylation
Intracellular response to process optimization and impact on productivity and product aggregates for a high-titer CHO ce
New high-throughput screening method for Chinese hamster ovary cell lines expressing low reduced monoclonal antibody lev
Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to
Constraint-based modeling and machine learning applications for analysis and optimization of fermentation parameters
Exploring metabolic responses and pathway changes in CHO-K1 cells under varied aeration conditions and copper supplement
Understanding the effect of increased cell specific productivity on galactosylation of monoclonal antibodies produced us
Semi-Automated Glycoproteomic Data Analysis of LC-MS Data Using GlycopeptideGraphMS in Process Development of Monoclonal
Impact of media and antifoam selection on monoclonal antibody production and quality using a high throughput micro‐biore
Strategies and Considerations for Improving Recombinant Antibody Production and Quality in Chinese Hamster Ovary Cells
Sodium chloride impacts glycosylation and N‐ and O‐glycan site occupancy of an Fc‐fusion protein
Optimization of parameters affecting on CHO cell culture producing recombinant erythropoietin.
Development, characterization, and application of a 2‐Compartment system to investigate the impact of pH inhomogeneities
Culture media optimization for Chinese hamster ovary cell growth and expression of recombinant varicella-zoster virus gl
Optimization of Chinese hamster ovary cell expression-based Fc fusion protein preparation process
Characterization of mammalian cell culture raw materials by combining spectroscopy and chemometrics
Comparison of mechanistic and hybrid modeling approaches for characterization of a CHO cultivation process: Requirements
Segmented linear modeling of CHO fed‐batch culture and its application to large scale production
CHOmpact: a reduced metabolic model of Chinese hamster ovary cells with enhanced interpretability
New high-throughput screening method for Chinese hamster ovary cell lines expressing low reduced monoclonal antibody lev
Quantification of the dynamics of population heterogeneities in CHO cultures with stably integrated fluorescent markers
An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation
Comparing Kinetic versus Stoichiometric Priorities in Hybrid Models of CHO Metabolism
Effects of various pine needle extracts on Chinese hamster ovary cell growth and monoclonal antibody quality
Elevated pCO<sub>2</sub> affects the lactate metabolic shift in CHO cell culture processes
Investigation and evaluation of a 3D‐printed optical modified cultivation vessel for improved scattered light measuremen
On‐Line Control of Glucose Concentration in High‐Yielding Mammalian Cell Cultures Enabled Through Oxygen Transfer Rate M
The relationship of metabolic burden to productivity levels in CHO cell lines.
Impact of cell culture media additives on IgG glycosylation produced in Chinese hamster ovary cells
Rapid Antibody Glycoengineering in Chinese Hamster Ovary Cells
A Metabolomics Approach to Increasing Chinese Hamster Ovary (CHO) Cell Productivity
Evaluation of NAD<sup>+</sup> precursors for improved metabolism and productivity of antibody‐producing CHO cell
Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells
A control strategy to investigate the relationship between specific productivity and high-mannose glycoforms in CHO cell
Genome-scale metabolic analysis reveals enhanced metabolism and antioxidative stress response in perfusion cell culture
microRNAs as potential tools for ‘miR’aculous CHO cell phenotypes in Bioprocessing systems
“Organized stress” for robust scale‐up of intensified production process with fed‐batch seed bioreactor
Oxygen Uptake Rate Soft-Sensing via Dynamic kLa Computation: Cell Volume and Metabolic Transition Prediction in Mammalia
Schistosoma mansoni alkaline phosphatase modulate platelet derived sphingosine-1-phosphate
Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation
A ‘Coomassie for Carbohydrates” - novel methodology for rapid detection and quantitation of glycosylated IgGs on an SDS-
Process mapping and optimization study of CHO cell cultures for mAb production using Ambr® 250 high-throughput parallel
Addressing amino acid‐derived inhibitory metabolites and enhancing CHO cell culture performance through DOE‐guided media
Improvement of Recombinant Proteins Production by Inducing Mitochondrial Biogenesis in CHO Cell Culture
Rosmarinic acid enhances CHO cell productivity and proliferation through activation of the unfolded protein response and
Glucose withdrawal-induced Chinese hamster ovary cells apoptosis and its potential role in process robustness assessment
Use of single analytic tool to quantify both absolute N‐glycosylation and glycan distribution in monoclonal antibodies
N-Glycosylation modulators for targeted manipulation of glycosylation for monoclonal antibodies
EGCG improves recombinant protein productivity in Chinese hamster ovary cell cultures via cell proliferation control
Developing microRNAs as engineering tools to modulate monoclonal antibody galactosylation
Quantification of glycated IgG in CHO supernatants: A practical approach
Strategies to control therapeutic antibody glycosylation during bioprocessing: Synthesis and separation
Effects of autophagy-inhibiting chemicals on sialylation of Fc-fusion glycoprotein in recombinant CHO cells
Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody–peptide
Manipulation of mRNA translation elongation influences the fragmentation of a biotherapeutic Fc‐fusion protein produced
Application of metabolic modeling for targeted optimization of high seeding density processes
Quality matters – Is IgM production influenced by external process conditions?
Glycoengineering Chinese hamster ovary cells: a short history
Over-expression of a Codon Optimized Yeast Cytosolic Pyruvate Carboxylase (PYC2) in CHO Cells for an Augmented Lactate M
Metabolic Network Modelling of Chinese Hamster Ovary (CHO) Culture Bioreactors Operated as Microbial Cell Factories
Mannose metabolism in recombinant CHO cells and its effect on IgG glycosylation.
Recombinant Human CD19 in CHO-K1 Cells: Glycosylation Patterns as a Quality Attribute of High Yield Processes
Production of trimeric SARS‐CoV‐2 spike protein by CHO cells for serological COVID‐19 testing
Media on‐demand: Continuous reconstitution of a chemically defined media directly from solids
Microevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactat
Feedback control of two supplemental feeds during fed-batch culture on a platform process using inline Raman models for
Impacts of intentional mycoplasma contamination on CHO cell bioreactor cultures.
Sequential Adaptation in Mammalian CHO-K1 Cells Producing Human Erythropoietin
Temperature Upshifts in Mammalian Cell Culture: A Suitable Strategy for Biosimilar Monoclonal Antibodies?
Culture media optimization for Chinese hamster ovary cell growth and expression of recombinant varicella-zoster virus gl
A hierarchical model combining process and Raman spectroscopic data for real-time monitoring of cell culture process
Profiling the dynamic changes in the phosphoproteome of Chinese hamster ovary cells
CHO cell productivity improvement by genome-scale modeling and pathway analysis: Application to feed supplements
Identification of novel miRNA targets in CHO cell lines and characterization of their impact on protein N-glycosylation
Investigating Low Culture Temperature and Low Media pH of Two Chinese Hamster Ovary (CHO) Cell Lines with Next Generatio
Decoupling Growth and Protein Production in CHO Cells: A Targeted Approach
Supplementation Strategies for Tuning Glycosylation of Monoclonal Antibodies and Enhancing Growth in Mammalian Cell Cult
Proteome-Wide Analysis of N-Glycosylation Stoichiometry Using SWATH Technology.
Evaluation of “Difficult‐to‐Express” Monoclonal Antibodies in a CHO‐Based Hybrid Site‐Specific Integration System Under
Impact Factors in the Process Development for Therapeutic Antibodies
Development of a scalable single process for producing SARS-CoV-2 RBD monomer and dimer vaccine antigens
Rapid Identification of Chinese Hamster Ovary Cell Apoptosis and Its Potential Role in Process Robustness Assessment
Model-based optimization of antibody galactosylation in CHO cell culture.
Deciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computa
Enhanced cell‐specific productivity through delayed supplementation of antioxidants in intensified processes
Employing QbD strategies to assess the impact of cell viability and density on the primary recovery of monoclonal antibo
Application of maltose as energy source in protein-free CHO-K1 culture to improve the production of recombinant monoclon
Polysome profiling of mAb producing CHO cell lines links translational control of cell proliferation and recombinant mRN
A genome‐scale nutrient minimization forecast algorithm for controlling essential amino acid levels in CHO cell cultures
Directed evolution of biomass intensive CHO cells by adaptation to sub-physiological temperature
BiP Inducer X: An ER Stress Inhibitor for Enhancing Recombinant Antibody Production in CHO Cell Culture
Analysis of Tubespins as a suitable scale-down model of bioreactors for high cell density CHO cell culture.
Toward Machine Learning-Guided CHO Bioprocess and Media Optimization for Improved Titer and Glycosylation.
Process development for an inducible rituximab‐expressing Chinese hamster ovary cell line
Impact of DO, agitation, aeration and copper concentration on lactate metabolism and charge heterogeneity for monoclonal
Enhancing recombinant protein and viral vector production in mammalian cells by targeting the YTHDF readers of <i>N</i><
Concentrated fed-batch cell culture increases manufacturing capacity without additional volumetric capacity.
Multivariate data analysis of process parameters affecting the growth and productivity of stable Chinese hamster ovary c
QbD-guided pharmaceutical development of Pembrolizumab biosimilar candidate PSG-024 propelled to industry meeting primar
Transcriptome Analysis of CHO Cell Size Increase During a Fed-Batch Process
Process intensification to produce a difficult‐to‐express therapeutic enzyme by high cell density perfusion or enhanced
Non-targeted characterization of attributes affecting antibody-FcγRIIIa V158 (CD16a) binding via online affinity chromat
Measurement and control of foam generation in a mammalian cell culture
Using MVDA with Stoichiometric Balances to Optimize Amino Acid Concentrations in Chemically Defined CHO Cell Culture Med
High-Throughput Platform Development for Chinese Hamster Ovary (CHO) Cell Culture Performance Enhancement Using Small Mo
Impact of temperature and pH on recombinant human IgM quality attributes and productivity.
Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Pr
Progress in fed-batch culture for recombinant protein production in CHO cells
Model-based intensification of CHO cell cultures: one-step strategy from fed-batch to perfusion
Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling
Continuous Feeding Reduces the Generation of Metabolic Byproducts and Increases Antibodies Expression in Chinese Hamster
Over-expression of a Codon Optimized Yeast Cytosolic Pyruvate Carboxylase (PYC2) in CHO Cells for an Augmented Lactate M
Dynamic parameter estimation and prediction over consecutive scales, based on moving horizon estimation: applied to an i
Metabolic Control in Mammalian Fed-Batch Cell Cultures for Reduced Lactic Acid Accumulation and Improved Process Robustn
N-Glycosylation modulators for targeted manipulation of glycosylation for monoclonal antibodies
Construction of a novel kinetic model for the production process of a CVA6 VLP vaccine in CHO cells
Model Predictive Control—A Stand Out among Competitors for Fed-Batch Fermentation Improvement
Evaluation and use of disaccharides as energy source in protein-free mammalian cell cultures
A Symbolic and Statistical Learning Framework to Discover Bioprocessing Regulatory Mechanism: Cell Culture Example
Evaluating the impact of media and feed combinations on CHO cell culture performance and monoclonal antibody (trastuzuma
Strategies Used in Manufacturing Processes to Drive and Control Mammalian Cells to Undergo a Lactate Metabolic Shift
Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing uni
Cell-culture growth conditions resulting in the oxidation of a recombinant antigen-binding fragment
Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data-driven and model-guided anal
Dynamic Optimization of a Fed-Batch Nosiheptide Reactor
Temperature Upshifts in Mammalian Cell Culture: A Suitable Strategy for Biosimilar Monoclonal Antibodies?
Automated Workflow for Instant Labeling and Real-Time Monitoring of Monoclonal Antibody N-Glycosylation
Identification of Cell Culture Factors Influencing Afucosylation Levels in Monoclonal Antibodies by Partial Least-Square
A ’Coomassie for Carbohydrates” – Novel Methodology for Rapid Detection and Quantitation of Glycosylated IgGs on an SDS-
Exploring metabolic effects of dipeptide feed media on CHO cell cultures by in silico model-guided flux analysis
Development and biological activity of long-acting recombinant human interferon-α2b
Induction of heat shock protein expression in SP2/0 transgenic cells and its effect on the production of monoclonal anti
Improved Time Resolved KPI and Strain Characterization of Multiple Hosts in Shake Flasks Using Advanced Online Analytics
A Metabolomics Approach to Increasing Chinese Hamster Ovary (CHO) Cell Productivity
Vibration Technology Makes It Possible to Obtain Standardized Biological Preparations: Vibrational Iterations Based on C
Designing Robust Biotechnological Processes Regarding Variabilities Using Multi-Objective Optimization Applied to a Biop
Hyperosmolarity Triggers the Warburg Effect in Chinese Hamster Ovary Cells and Reveals a Reduced Mitochondria Horsepower
Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombin
Off-Gas-Based Soft Sensor for Real-Time Monitoring of Biomass and Metabolism in Chinese Hamster Ovary Cell Continuous Pr
Single-Use Printed Biosensor for L-Lactate and Its Application in Bioprocess Monitoring
Insights into the Impact of Rosmarinic Acid on CHO Cell Culture Improvement through Transcriptomics Analysis
Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch a
On-line glucose monitoring by near infrared spectroscopy during the scale up steps of mammalian cell cultivation process
A novel approach to noninvasive monitoring of dissolved carbon dioxide in small-scale cell culture processes
Similarity assessment by multivariate statistics method based on the distance between biosimilar and originator
Process transfer and optimization of Chinese hamster ovary cell cultivation for monoclonal antibody production
3D Printed, Single-Use Bioreactor with Integrated Inline Sensors for Microbial and Mammalian Cell Cultivation—A Case Stu
A dynamic metabolic flux analysis (DMFA) model for performance predictions of diverse CHO cell culture process modes and
Advancements in CHO metabolomics: techniques, current state and evolving methodologies
Modeling, estimation, and control of glycosylation in monoclonal antibodies produced in CHO cells
Developing a medium combination to attain similar glycosylation profile to originator by DoE and cluster analysis method
Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cell
A control strategy to investigate the relationship between specific productivity and high-mannose glycoforms in CHO cell
mAb Production Modeling and Design Space Evaluation Including Glycosylation Process
Machine learning and metabolic modelling assisted implementation of a novel process analytical technology in cell and ge
Monitoring of Nutrients, Metabolites, IgG Titer, and Cell Densities in 10 L Bioreactors Using Raman Spectroscopy and PLS
Modulating antibody N-glycosylation through feed additives using a multi-tiered approach
CO&lt;sub&gt;2&lt;/sub&gt; Control Strategy for Large-Scale Cell Culture Bioreactor Operation
Antibody Productivity of CHO Cells is Altered by ER Stress Tolerance of the Host Cell
Maximum entropy and population heterogeneity in continuous cell cultures
Stability and Requirement for Thiamin in a Cell Culture Feed Used to Produce New Biological Entities
Triple Space-Time Yield in Discontinuous Antibody Biomanufacturing by Combination of Synergetic Process Intensification
Tyrosine O-sulfation proteoforms affect HIV-1 monoclonal antibody potency
Strategies and Considerations for Improving Recombinant Antibody Production and Quality in Chinese Hamster Ovary Cells
Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells
A Linkage-specific Sialic Acid Labeling Strategy Reveals Different Site-specific Glycosylation Patterns in SARS-CoV-2 Sp
Model-based intensification of CHO cell cultures: one-step strategy from fed-batch to perfusion
Mucin 21 confers resistance to apoptosis in an O-glycosylation-dependent manner
Sialic acid and fucose residues on the SARS-CoV-2 receptor binding domain modulate IgG reactivity
Seed train process intensification strategy offers potential for rapid, cost-effective scale-up of biosimilars manufactu
Scale-up of CHO cell cultures: from 96-well-microtiter plates to stirred tank reactors across three orders of magnitude
Microevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactat
Recombinant Human CD19 in CHO-K1 Cells: Glycosylation Patterns as a Quality Attribute of High Yield Processes
Impact of Acetylated and Non-Acetylated Fucose Analogues on IgG Glycosylation
Chromophore pre-maturation for improved speed and sensitivity of split-GFP monitoring of protein secretion
Modern Sensor Tools and Techniques for Monitoring, Controlling, and Improving Cell Culture Processes
Optimization of Culture Conditions to Improve Follicle-Stimulating Hormone Production by CHO-DG44 Cells in Serum-Free Me
Choice of host cell line is essential for the functional glycosylation of the fragment crystallizable (Fc) region of hum
Oxygen Uptake Rate Soft-Sensing via Dynamic kLa Computation: Cell Volume and Metabolic Transition Prediction in Mammalia
Cell clone selection—impact of operation modes and medium exchange strategies on clone ranking
Sequential Parameter Estimation for Mammalian Cell Model Based on In Silico Design of Experiments
A metabolic network-based approach for developing feeding strategies for CHO cells to increase monoclonal antibody produ
An Investigation into the Metabolic Differences between Conventional and High Seeding Density Fed-Batch Cell Cultures by
Model-Based Optimization of a Fed-Batch Bioreactor for mAb Production Using a Hybridoma Cell Culture
Glycosylation Flux Analysis of Immunoglobulin G in Chinese Hamster Ovary Perfusion Cell Culture
Exploring synthetic biology for the development of a sensor cell line for automated bioprocess control
The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells
Enzyme capacity-based genome scale modelling of CHO cells
Towards Autonomous Operation by Advanced Process Control—Process Analytical Technology for Continuous Biologics Antibody
Metabolic Profiling of CHO Cells during the Production of Biotherapeutics
Exploring the limits of conventional small-scale CHO fed-batch for accelerated on demand monoclonal antibody production
Glycoproteomic Characterization of FUT8 Knock-Out CHO Cells Reveals Roles of FUT8 in the Glycosylation
New Insights from Locally Resolved Hydrodynamics in Stirred Cell Culture Reactors
A novel hybrid bioprocess strategy addressing key challenges of advanced biomanufacturing
Application of bioreactor technology for cell culture-based viral vaccine production: Present status and future prospect
Genome-scale modeling of Chinese hamster ovary cells by hybrid semi-parametric flux balance analysis
Model-Based Methods in the Biopharmaceutical Process Lifecycle
O-Glycoproteomic analysis of engineered heavily glycosylated fusion proteins using nanoHILIC-MS
Rapid Identification of Chinese Hamster Ovary Cell Apoptosis and Its Potential Role in Process Robustness Assessment
Development of a scalable single process for producing SARS-CoV-2 RBD monomer and dimer vaccine antigens
Cell-Sonar, a Novel Method for Intracellular Tracking of Secretory Pathways
<i>N</i>-Glycosylation profiling of intact target proteins by high-resolution mass spectrometry (MS) and glycan analysis
Implementation of Design of Experiments (DOE) for Optimization of Feeding Strategy and Glyco-Engineering of Trastuzumab
Evidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies prod
Development of a stable antibody production system utilizing an Hspa5 promoter in CHO cells
Hyperosmolality in CHO cell culture: effects on the proteome
Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation
Effect of Sialic Acid on Mammalian Cell Culture and Protein Expression: A Potential Productivity Enhancer for Biopharmac
Pre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensificati
Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Producti
BioDT: An Integrated Digital-Twin-Based Framework for Intelligent Biomanufacturing
Production of Trimeric SARS-CoV-2 Spike Protein by CHO Cells for Serological COVID-19 Testing
Nicotinamide reverses the Warburg effect in Chinese hamster ovary cell culture
Metabolic characterization of a CHO cell size increase phase in fed-batch cultures
Perspective Chapter: Advanced Process Control and Automation with Special Focus on Emerging Continuous Bioprocessing
A Framework for the Development of Integrated and Computationally Feasible Models of Large-Scale Mammalian Cell Bioreact
Optimizing the Production of gp145, an HIV-1 Envelope Glycoprotein Vaccine Candidate and Its Encapsulation in Guanosine
Explainable AI for CHO cell culture media optimization and prediction of critical quality attribute
Dynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Ada
A recombinant gp145 Env glycoprotein from HIV-1 expressed in two different cell lines: effects on glycosylation and anti
Investigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critic
On-line reoptimization of mammalian fed-batch culture using a nonlinear model predictive controller
Accelerating Biologics Manufacturing by Upstream Process Modelling
Optimization of transient protein production by chemically transfected CHO suspension cells
Development of an intensified fed-batch production platform with doubled titers using N-1 perfusion seed for cell cultur
Decoupling Growth and Protein Production in CHO Cells: A Targeted Approach
Effects of autophagy-inhibiting chemicals on sialylation of Fc-fusion glycoprotein in recombinant CHO cells
Enhancing and stabilizing monoclonal antibody production by Chinese hamster ovary (CHO) cells with optimized perfusion c
Comparison of Three Glycoproteomic Methods for the Analysis of the Secretome of CHO Cells Treated with 1,3,4-O-Bu3ManNAc
Quantitative N-Glycan Profiling of Therapeutic Monoclonal Antibodies Performed by Middle-Up Level HILIC-HRMS Analysis
Genome-editing techniques to increase the therapeutic efficacy of monoclonal antibodies
Therapeutic Fc fusion protein misfolding: A three-phasic cultivation experimental design
HIV-1 vaccine design through minimizing envelope metastability
High-Level Production of scFv-Fc Antibody Using an Artificial Promoter System with Transcriptional Positive Feedback Loo
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secre
A Systematic Approach to Time-series Metabolite Profiling and RNA-seq Analysis of Chinese Hamster Ovary Cell Culture
Roles of N-linked and O-linked glycosylation sites in the activity of equine chorionic gonadotropin in cells expressing
Chinese Hamster Ovary Cell Line Development via Imaging Flow Cytometry and Directed Evolution
Hybrid Modelling and Multi- Parametric Control of Bioprocesses
Real-time characterization of mammalian cell culture bioprocesses by magnetic sector MS
Compartment-specific metabolome labeling enables the identification of subcellular fluxes that may serve as promising me
Risk-Based Control Strategies of Recombinant Monoclonal Antibody Charge Variants
Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with
Halfway to Automated Feeding of Chinese Hamster Ovary Cells
Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins
Boosting Productivity for Advanced Biomanufacturing by Re-Using Viable Cells
Visualization of the HIV-1 Env Glycan Shield Across Scales
Subspace Based Model Identification for an Industrial Bioreactor: Handling Infrequent Sampling Using Missing Data Algori
Microbioreactors and Perfusion Bioreactors for Microbial and Mammalian Cell Culture
Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion
Population balance modelling captures host cell protein dynamics in CHO cell cultures
Multiplex secretome engineering enhances recombinant protein production and purity
Strategic Framework for Parameterization of Cell Culture Models
High shear resistance of insect cells: the basis for substantial improvements in cell culture process design
Selection of chemically defined media for CHO cell fed-batch culture processes
Effects of process intensification on homogeneity of an IgG1:κ monoclonal antibody during perfusion culture
Animal Cell Expression Systems.
Deciphering Metabolic Pathways in High Seeding Density Fed-Batch Processes for Monoclonal Antibody Production: A Computa
Viable cell density as an indicator for dynamic feeding strategy in fed-batch and perfusion CHO cell culture
Simplifying glycan monitoring of complex antigens such as the SARS-CoV-2 spike to accelerate vaccine development
Exploring Parametric and Mechanistic Differences between Expi293FTM and ExpiCHO-STM Cells for Transient Antibody Product
Prediction of N-linked Glycoform Profiles of Monoclonal Antibody with Extracellular Metabolites and Two-Step Intracellul
Sensor Selection and State Estimation of Continuous mAb Production Processes
Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclo
A Hybrid Modeling Framework for Predictive Digital Twins of CHO Cell Culture
Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified product
Similarity Assessment by Multivariate Statistics Method Based on Distance Between Biosimilar and Originator
Characterization and design of dipeptide media formulation for scalable therapeutic production
Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling
Uridine modulates monoclonal antibody charge heterogeneity in Chinese hamster ovary cell fed-batch cultures
Comprehensive modeling of cell culture profile using Raman spectroscopy and machine learning
Investigating the influence of physiologically relevant hydrostatic pressure on CHO cell batch culture
Soft sensor for monitoring biomass subpopulations in mammalian cell culture processes
Boost dynamic protocols for producing mammalian biopharmaceuticals with intensified DoE—a practical guide to analyses wi
Abstracts from the 26th European Society for Animal Cell Technology Meeting - Cell culture technologies: bridging academ
Screening of Membrane Protein Production by Comparison of Transient Expression in Insect and Mammalian Cells
Using Metabolomics to Identify Cell Line-Independent Indicators of Growth Inhibition for Chinese Hamster Ovary Cell-Base
SWATH-MS insights on sodium butyrate effect on mAbs production and redox homeostasis in CHO cells
Clustering and curation of electropherograms: an efficient method for analyzing large cohorts of capillary electrophores
Ouantitative Proteomic Analysis of Cellular Responses to a Designed Amino Acid Feed in a Monoclonal Antibody Producing C
Metabolic engineering of CHO cells for the development of a robust protein production platform
Mapping the molecular basis for growth related phenotypes in industrial producer CHO cell lines using differential prote
Differential expression of miRNAs and functional role of mir-200a in high and low productivity CHO cells expressing an F
Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production
Methods for Using Small Non-Coding RNAs to Improve Recombinant Protein Expression in Mammalian Cells
Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster
An integrated strategy reveals complex glycosylation of erythropoietin using top-down and bottom-up mass spectrometry
Towards Autonomous Process Control—Digital Twin for CHO Cell-Based Antibody Manufacturing Using a Dynamic Metabolic Mode
A simple method to determine evaporation and compensate for liquid losses in small-scale cell culture systems
Challenges and Emerging Technologies in Biomanufacturing of Monoclonal Antibodies (mAbs)
A recombinant gp145 Env glycoprotein from HIV-1 expressed in two different cell lines: Effects on glycosylation and anti
Osmolality Effects on CHO Cell Growth, Cell Volume, Antibody Productivity and Glycosylation
Proteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO Cells
Optimization and Scale-Up of Fermentation Processes Driven by Models
High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat
Enhancement of recombinant human IL-24 (rhIL-24) protein production from site-specific integrated engineered CHO cells b
Application of maltose as energy source in protein-free CHO-K1 culture to improve the production of recombinant monoclon
Specific Biological Activity of Equine Chorionic Gonadotropin (eCG) Glycosylation Sites in Cells Expressing Equine Lutei
Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture super
PID controls: the forgotten bioprocess parameters
Model-Based Optimization of a Fed-Batch Bioreactor for mAb Production Using a Hybridoma Cell Culture
Modifying the glycosylation profile of SARS-CoV-2 spike-based subunit vaccines alters focusing of the humoral immune res
Effect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human T
Advances of Glycometabolism Engineering in Chinese Hamster Ovary Cells
Structural and functional characterization of SARS-CoV-2 RBD domains produced in mammalian cells
Responses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabol
Gene editing in CHO cells to prevent proteolysis and enhance glycosylation: Production of HIV envelope proteins as vacci
Development, Engineering and Biological Characterization of Stirred Tank Bioreactors
Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Sp
Integration Approaches to Model Bioreactor Hydrodynamics and Cellular Kinetics for Advancing Bioprocess Optimisation
Glycosylation Flux Analysis of Immunoglobulin G in Chinese Hamster Ovary Perfusion Cell Culture
Abstracts from the 25th European Society for Animal Cell Technology Meeting: Cell Technologies for Innovative Therapies
Deciphering Metabolic Pathways in High-Seeding-Density Fed-Batch Processes for Monoclonal Antibody Production: A Computa
Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells
A Simple Method to Reduce both Lactic Acid and Ammonium Production in Industrial Animal Cell Culture
Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/
Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors
Quantification of the dynamics of population heterogeneities in CHO cultures with stably integrated fluorescent markers
Clever Experimental Designs: Shortcuts for Better iPSC Differentiation
Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch
Understanding and Controlling Sialylation in a CHO Fc-Fusion Process
Aucoin, Marc G.
maucoin@uwaterloo.ca
Impact of Dissolved Oxygen during UV-Irradiation on the Chemical Composition and Function of CHO Cell Culture Media
Viewliqi@jiangnan.edu.cn
Optimization of the Process of Chinese Hamster Ovary (CHO) Cell Fed-Batch Culture to Stabilize Monoclonal Antibody Produ
oznur.ozaslan@gmail.com
Development of a serum free medium for HUMIRA <sup>®</sup> biosimilar by design of experiment approaches
andersonca@duq.edu
Enhancing analytical sensitivity in upstream bioprocess using time-gated Raman spectroscopy.
w.xie@northeastern.edu
Digital Twin Calibration for Biological System-of-Systems: Cell Culture Manufacturing Process
yanxu@novabiologiques.com
PF-D-Trimer, a protective SARS-CoV-2 subunit vaccine: immunogenicity and application
adi.santoso1960@gmail.com
Expression of Human Erythropoietin Containing 2 Additional N-Link in CHO-K1 Cells under Different Culture Conditions
D.Gerogiorgis@ed.ac.uk
Dynamic Optimisation of Fed-Batch Bioreactors for mAbs: Sensitivity Analysis of Feed Nutrient Manipulation Profiles